Volume 24 Issue 1
Jan.  2026
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TAO Yiqing, SHEN Aijuan, SHENG Wei. The mechanism of Xuanfei Jianpi Decoction in improving pulmonary function of stable COPD patients[J]. Chinese Journal of General Practice, 2026, 24(1): 83-87. doi: 10.16766/j.cnki.issn.1674-4152.004335
Citation: TAO Yiqing, SHEN Aijuan, SHENG Wei. The mechanism of Xuanfei Jianpi Decoction in improving pulmonary function of stable COPD patients[J]. Chinese Journal of General Practice, 2026, 24(1): 83-87. doi: 10.16766/j.cnki.issn.1674-4152.004335
shu

The mechanism of Xuanfei Jianpi Decoction in improving pulmonary function of stable COPD patients

doi: 10.16766/j.cnki.issn.1674-4152.004335
  • 1.

    Pulmonary Function Room, Jiaxing University Affiliated TCM Hospital, Jiaxing, Zhejiang 314001, China

Funds:

 2025ZL129

  • Received Date: 2025-07-18
    Available Online: 2026-04-01
    Abstract
  •   Objective  This paper observes the efficacy of Xuanfei Jianpi Decoction in mitigating the clinical symptoms exhibited by patients diagnosed with stable chronic obstructive pulmonary disease (COPD, with lung spleen qi deficiency syndrome) and the mechanism behind it.  Methods  A total of 100 stable COPD patients (with lung spleen qi deficiency syndrome) admitted Jiaxing Hostipal of TCM from January 2023 to June 2025 were randomly divided into two groups: a control group (50 cases) and an observation group (50 cases). The control group was administered a combination of inhaled salmeterol and fluticasone combined with tiotropium bromide, while the observation group was treated with the oral Xuanfei Jianpi Decoction. The curative effects on the traditional Chinese medicine syndome in patients were monitored along with COPD symptoms, exercise endurance, and improvement of lung function, The serum inflammatory factor levels were detected, and analyze changes in the T helper 17 cell (Th17)/ regulatory T cell (Treg) immune balance status were analyzed.  Results  Following a period of eight weeks, the overall effective rate was higher in the observation group than in the control group [92.00% (46/50) vs. 72.00% (36/50), χ2=6.775, P=0.009]. The COPD assessment test (CAT) score, modified medical research council (mMRC) score, and Borg score of the observation group were found to be lower than control group (P < 0.001), while the 6-min walk distance (6MWD) value was found to be higher in the observation group than in the control group. The values of lung function indicators such as forced expiratory volume in 1 sec (FEV1), FEV1/forced vital capacity (FVC), and FVC% Pred, were found to be higher in the observation group in comparison to the control group (P < 0.001). The detection values of Th17, Treg, and Th17/Treg in the serum of the observation group were lower than those in the control group (P < 0.001). The levels of inflammatory factors, including tumor necrosis factor-α, interleukin-1β and interleukin-17 in the serum of the observation group were lower than the control group (P < 0.001).  Conclusion  The Xuanfei Jianpi Decoction has been shown to effectively alleviate traditional Chinese medicine syndromes and clinical symptoms in patients with stable COPD (accompanied by lung spleen qi deficiency syndrome), improve lung function and exercise endurance. The pharmacological mechanism of the substance under investigation is closely related to the regulation of cellular immune function and the inhibition of respiratory inflammatory response.

     

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