Volume 24 Issue 1
Jan.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(1): 117-120
YANG Zhipeng, XIAN Rong, XI Yujiang, ZHANG Xiaoli, OUYANG Li, XIAO Hong. Multi-target mechanisms of the sphingosine-1-phosphate signaling pathway in regulating airway remodeling in asthma[J]. Chinese Journal of General Practice, 2026, 24(1): 117-120. doi: 10.16766/j.cnki.issn.1674-4152.004343
Citation: YANG Zhipeng, XIAN Rong, XI Yujiang, ZHANG Xiaoli, OUYANG Li, XIAO Hong. Multi-target mechanisms of the sphingosine-1-phosphate signaling pathway in regulating airway remodeling in asthma[J]. Chinese Journal of General Practice, 2026, 24(1): 117-120. doi: 10.16766/j.cnki.issn.1674-4152.004343
shu

Multi-target mechanisms of the sphingosine-1-phosphate signaling pathway in regulating airway remodeling in asthma

doi: 10.16766/j.cnki.issn.1674-4152.004343
  • 1.

    The First Clinical Medical College of Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan 650000, China

Funds:

 YNWR-MY-2019-044

 2025Y0636

 云卫中医发展发〔2025〕1号

  • Received Date: 2025-04-03
    Available Online: 2026-04-01
    Abstract
  • The sphingosine-1-phosphate (S1P) signaling pathway is the key component of sphingolipid metabolism. It mediates cell proliferation, migration, survival, immune cell trafficking, and angiogenesis via S1PR1-5 receptors. It plays key roles in immunomodulation, inflammation, and tissue remodeling. Recent advances in metabolomics and signaling research highlight the growing link between S1P signaling and chronic inflammatory diseases like such as asthma. A core pathological feature of asthma is airway remodeling (AR), characterized by irreversible structural alterations including abnormal airway smooth muscle cell (ASMC) proliferation or migration, epithelial-mesenchymal transition (EMT), fibrosis, and pathological angiogenesis. Current research shows the S1P pathway targets multiple aspects of asthma AR: it drives ASMC proliferation, migration, and contraction by activating axes such as S1PR2/3-Rho/ROCK and STAT3/YAP/Notch3; it downregulates epithelial markers while upregulating mesenchymal markers to promote EMT and fibrosis; and it synergizes with VEGF to mediate pathological angiogenesis, exacerbating the hypoxia-inflammation-remodeling cycle. This review systematically examines the regulatory network of the S1P pathway in asthma AR and its therapeutic potential, aiming to provide a foundation for novel, multi-targeted strategies for AR intervention.

     

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