Volume 24 Issue 1
Jan.  2026
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ZHU Yunyun, YANG Dongjian, LENG Shufang, LI Hong. Association of paternal dietary patterns with birth weight of assisted reproduction offspring[J]. Chinese Journal of General Practice, 2026, 24(1): 149-154. doi: 10.16766/j.cnki.issn.1674-4152.004350
Citation: ZHU Yunyun, YANG Dongjian, LENG Shufang, LI Hong. Association of paternal dietary patterns with birth weight of assisted reproduction offspring[J]. Chinese Journal of General Practice, 2026, 24(1): 149-154. doi: 10.16766/j.cnki.issn.1674-4152.004350
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Association of paternal dietary patterns with birth weight of assisted reproduction offspring

doi: 10.16766/j.cnki.issn.1674-4152.004350
  • 1.

    Nursing Department, the International Peace Maternal and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China

Funds:

 2022YFC2702903

 Jyh2402

  • Received Date: 2025-01-21
    Available Online: 2026-04-01
    Abstract
  •   Objective  To explore the correlation between the father ' s dietary pattern and the birth weight of assisted reproductive technology (ART) offspring, and analyze the relevant dietary factors influencing the weight of offspring, and provide a basis for promoting the healthy development of ART offspring.  Methods  A total of 904 groups of fathers and ART offspring recruited in the China National Birth Cohort (CNBC) project from January 1, 2017 to December 31, 2021 were selected as the research subjects. The dietary intake was collected using the semi-quantitative food frequency questionnaire, the dietary patterns were extracted by principal component analysis, and the association between the father ' s dietary patterns and the birth weight of ART offspring was analyzed using the restricted cube function and multivariate logistic regression.  Results  Five dietary patterns were summarized through principal component analysis: the "fruit and vegetable" model, the "high purine" model, the "plant-based staple food" model, the "high-quality animal protein" model, and the "sugar-lipid" model. Grouped by quartiles of dietary pattern scores and after adjusting for covariates, compared with the group where the father was in the "high-quality animal protein" pattern Q1 (lowest), the ART offspring in the Q4 group (highest) had a lower risk of small for gestational age (SGA, OR=0.257, 95% CI: 0.079-0.712), and the SGA risk decreased with the increase of the score (P-trend=0.007).  Conclusion  A dietary pattern of "high-quality animal protein" adopted by fathers may reduce the risk of SGA in the offspring of ART. Fathers should increase their intake of high-quality protein during the preconception period to ensure the normal growth and development of the fetus and reduce the risk of adverse birth outcomes.

     

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