Volume 24 Issue 2
Feb.  2026
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(2): 205-208
MU Hong, CAO Pengyu, ZHOU Shan, GUO Tong, CHEN Siyu, Jalalimanesh Rahim, CHEN Yuru, SUN Yulin, LIU Jiexin, XU Bin, MA Li. The effect of syncope on the overall survival after surgery for hepatocellular carcinoma patients[J]. Chinese Journal of General Practice, 2026, 24(2): 205-208. doi: 10.16766/j.cnki.issn.1674-4152.004361
Citation: MU Hong, CAO Pengyu, ZHOU Shan, GUO Tong, CHEN Siyu, Jalalimanesh Rahim, CHEN Yuru, SUN Yulin, LIU Jiexin, XU Bin, MA Li. The effect of syncope on the overall survival after surgery for hepatocellular carcinoma patients[J]. Chinese Journal of General Practice, 2026, 24(2): 205-208. doi: 10.16766/j.cnki.issn.1674-4152.004361
shu

The effect of syncope on the overall survival after surgery for hepatocellular carcinoma patients

doi: 10.16766/j.cnki.issn.1674-4152.004361
  • 1.

    Department of Emergency, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

Funds:

 82073327

 TYGL202406

 XSKY2025336

  • Received Date: 2025-02-11
    Available Online: 2026-04-11
    Abstract
  •   Objective  To explore the impact of postoperative syncope on survival of hepatocellular carcinoma (HCC) patients, and aim to provide references for further improving the postoperative management of patients with HCC and the quality of hospice care.  Methods  HCC patients who underwent surgical resection from January 2014 to December 2017 were included in the study and followed up until death. Basic clinical information and postoperative rehabilitation clinical data were collected for survival analysis, including syncope, distant recurrence and metastasis. The Kaplan-Meier method and the Cox proportional hazards regression model were employed for univariate and multivariate analysis to screen for potential risk factors on overall survival.  Results  A total of 105 patients were observed until death from HCC, and the overall median survival time was (805.4±45.7) days. Univariate Cox regression analysis demonstrated that the presence of diabetes history, elevated alpha fetoprotein (AFP) levels, distant metastasis within a year, syncope within a year, and higher American Joint Committee on Cancer (AJCC) stage exerted a statistically significant influence on the total survival period after HCC surgery. Multivariate Cox regression analysis demonstrated that elevated AFP value (OR=1.669, 95% CI: 1.031-2.704) and advanced AJCC stage (OR=1.322, 95% CI: 1.037-1.685) were independent risk factors.  Conclusion  This study hypothesizes that the incidence of syncope in one year has the potential to impact the overall survival of HCC patients post-surgery, and that it may be influenced by other risk factors interactively or indirectly, a factor which requires attention in future research.

     

    • FullText(HTML)
  • loading
    • References(27)
  • [1]
    BRAY F, LAVERSANNE M, SUNG H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3): 229-263.
    [2]
    XIE J, LIN X, FAN X, et al. Global burden and trends of primary liver cancer attributable to comorbid type 2 diabetes mellitus among people living with hepatitis B: an observational trend study from 1990 to 2019[J]. J Epidemiol Glob Health, 2024, 14(2): 398-410. doi: 10.1007/s44197-024-00237-1
    [3]
    DU J S, HSU S H, WANG S N. The current and prospective adjuvant therapies for hepatocellular carcinoma[J]. Cancers(Basel), 2024, 6(7): 1422. DOI: 10.3390/cancers16071422.
    [4]
    LORENZEN M O B, FARKAS D K, ADELBORG K, et al. Syncope as a sign of occult cancers: a population-based cohort study[J]. Br J Cancer, 2020, 122(4): 595-600. doi: 10.1038/s41416-019-0692-2
    [5]
    XIE D Y, ZHU K, REN Z G, et al. A review of 2022 Chinese clinical guidelines on the management of hepatocellular carcinoma: updates and insights[J]. Hepatobiliary Surg Nutr, 2023, 12(2): 216-228. doi: 10.21037/hbsn-22-469
    [6]
    中华心血管病杂志编辑委员会, 中国生物医学工程学会心律分会, 中国老年学和老年医学学会心血管病专业委员会, 等. 晕厥诊断与治疗中国专家共识(2018)[J]. 中华心血管病杂志, 2019, 47(2): 96-107.

    Editorial Board of Chinese Journal of Cardiology, Heart Rhythm Branch of Chinese Society of Biomedical Engineering, Cardiovascular Diseases Branch of China Association of Gerontology and Geriatrics, et al. Chinese expert consensus statement on clinical diagnosis and treatment of syncope 2018[J]. Chin J Cardiol, 2019, 47(2): 96-107.
    [7]
    AKSU T, BRIGNOLE M, CALO L, et al. Cardioneuroablation for the treatment of reflex syncope and functional bradyarrhythmias: a scientific statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS) and the Latin American Heart Rhythm Society (LAHRS)[J]. Europace, 2024, 26(8): euae206. DOI: 10.1093/europace/euae206.
    [8]
    HAN B, ZHENG R, ZENG H, et al. Cancer incidence and mortality in China, 2022[J]. J Natl Cancer Cent, 2024, 4(1): 47-53.
    [9]
    DUCREUX M, ABOU-ALFA G K, BEKAⅡ-SAAB T, et al. The management of hepatocellular carcinoma. Current expert opinion and recommendations derived from the 24th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2022[J]. ESMO Open, 2023, 8(3): 101567. DOI: 10.1016/j.esmoop.2023.101567.
    [10]
    MA Y N, JIANG X, SONG P, et al. Neoadjuvant therapies in resectable hepatocellular carcinoma: exploring strategies to improve prognosis[J]. Biosci Trends, 2024, 18(1): 21-41. doi: 10.5582/bst.2023.01436
    [11]
    ZHENG Y, ZHU M, LI M. Effects of alpha-fetoprotein on the occurrence and progression of hepatocellular carcinoma[J]. J Cancer Res Clin Oncol, 2020, 146(10): 2439-2446. doi: 10.1007/s00432-020-03331-6
    [12]
    LI Y C, LI L Y, TONG H C, et al. Pulmonary artery intimal sarcoma mimicking pulmonary thromboembolism: a case report[J]. Medicine(Baltimore), 2021, 100(6): e24699. DOI: 10.1097/MD.0000000000024699.
    [13]
    MAGNON C, HONDERMARCK H. The neural addiction of cancer[J]. Nat Rev Cancer, 2023, 23(5): 317-334. doi: 10.1038/s41568-023-00556-8
    [14]
    AMATO M, PIAZZA P, FERRARI I, et al. Rare perinephric myxoid pseudotumor of fat causing ureteropelvic junction obstruction: a case report[J]. CEN Case Rep, 2023, 12(2): 210-214.
    [15]
    KHORANA A A, MACKMAN N, FALANGA A, et al. Cancer-associated venous thromboembolism[J]. Nat Rev Dis Primers, 2022, 8(1): 11. DOI: 10.1038/s41572-022-00336-y.
    [16]
    YEO Y H, LEE Y T, TSENG H R, et al. Alpha-fetoprotein: past, present, and future[J]. Hepatol Commun, 2024, 8(5): e0422. DOI: 10.1097/HC9.0000000000000422.
    [17]
    LIU D, SONG T. Changes in and challenges regarding the surgical treatment of hepatocellular carcinoma in China[J]. Biosci Trends, 2021, 15(3): 142-147. doi: 10.5582/bst.2021.01083
    [18]
    COURI T, PILLAI A. Goals and targets for personalized therapy for HCC[J]. Hepatol Int, 2019, 13(2): 125-137. doi: 10.1007/s12072-018-9919-1
    [19]
    GALLI E, PATELLI G, VILLA F, et al. Circulating blood biomarkers for minimal residual disease in hepatocellular carcinoma: a systematic review[J]. Cancer Treat Rev, 2025, 135: 102908. DOI: 10.1016/j.ctrv.2025.102908.
    [20]
    DOMINGUEZ D A, WONG P, MELSTROM L G. Existing and emerging biomarkers in hepatocellular carcinoma: relevance in staging, determination of minimal residual disease, and monitoring treatment response: a narrative review[J]. Hepatobiliary Surg Nutr, 2024, 13(1): 39-55. doi: 10.21037/hbsn-22-526
    [21]
    CHANG Y, WONG C E, LEE P H, et al. Survival outcome of surgical resection vs. radiotherapy in brain metastasis from colorectal cancer: a meta-analysis[J]. Front Med(Lausanne), 2022, 9: 768896. DOI: 10.3389/fmed.2022.768896.
    [22]
    伍龙, 吴欢, 黄飞, 等. 循环肿瘤DNA在结直肠癌中的应用[J]. 中华全科医学, 2024, 22(3): 368-371. doi: 10.16766/j.cnki.issn.1674-4152.003404

    WU L, WU H, HUANG F, et al. Circulating tumor DNA in colorectal cancer[J]. Chinese Journal of General Practice, 2024, 22(3): 368-371. doi: 10.16766/j.cnki.issn.1674-4152.003404
    [23]
    HO N T, ABE S K, RAHMAN M S, et al. Diabetes is associated with increased liver cancer incidence and mortality in adults: a report from Asia Cohort Consortium[J]. Int J Cancer, 2024, 155(5): 854-870. doi: 10.1002/ijc.34965
    [24]
    SINGH M K, DAS B K, CHOUDHARY S, et al. Diabetes and hepatocellular carcinoma: a pathophysiological link and pharmacological management[J]. Biomed Pharmacother, 2018, 106: 991-1002. doi: 10.1016/j.biopha.2018.06.095
    [25]
    胡慧英, 张征宇. 运动干预在老年糖尿病周围神经病变患者中的应用效果[J]. 中华全科医学, 2020, 18(5): 769-772. doi: 10.16766/j.cnki.issn.1674-4152.001352

    HU H Y, ZHANG Z Y. Effect of exercise intervention in elderly patients with diabetic peripheral neuropathy[J]. Chinese Journal of General Practice, 2020, 18(5): 769-772. doi: 10.16766/j.cnki.issn.1674-4152.001352
    [26]
    SUDO S Z, MONTAGNOLI T L, ROCHA B S, et al. Diabetes-induced cardiac autonomic neuropathy: impact on heart function and prognosis[J]. Biomedicines, 2022, 10(12): 3258. DOI: 10.3390/biomedicines10123258.
    [27]
    DAS B K, GADAD P C. Impact of diabetes on the increased risk of hepatic cancer: an updated review of biological aspects[J]. Diabetes Epidemiol Manag, 2021, 4: 100025. DOI: 10.1016/j.deman.2021.100025.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (6) PDF downloads(0) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return