Volume 24 Issue 2
Feb.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(2): 235-238
ZHAI Tianqi, JIANG Zhenyu, ZHANG Jingjie, NIAN Yuanyuan, MENG Xianmei. A two-sample Mendelian randomization study on the causal relationship between gastroesophageal reflux disease and irritable bowel syndrome[J]. Chinese Journal of General Practice, 2026, 24(2): 235-238. doi: 10.16766/j.cnki.issn.1674-4152.004368
Citation: ZHAI Tianqi, JIANG Zhenyu, ZHANG Jingjie, NIAN Yuanyuan, MENG Xianmei. A two-sample Mendelian randomization study on the causal relationship between gastroesophageal reflux disease and irritable bowel syndrome[J]. Chinese Journal of General Practice, 2026, 24(2): 235-238. doi: 10.16766/j.cnki.issn.1674-4152.004368
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A two-sample Mendelian randomization study on the causal relationship between gastroesophageal reflux disease and irritable bowel syndrome

doi: 10.16766/j.cnki.issn.1674-4152.004368

  • Department of Gastroenterology, the Second Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia 014030, China

Funds:

 2024ZD28

  • Received Date: 2025-09-11
    Available Online: 2026-04-11
    Abstract
  •   Objective  Gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) are the most common gastrointestinal diseases. GERD and IBS have different degrees of impact on patients ' daily life, work and psychological state. This study aims to explore the causal relationship between GERD and IBS using Mendelian randomization (MR).  Methods  GERD data and IBS data were all from the GWAS database, including 1 590 227 GERD samples (462 753 cases in the case group and 1 127 474 cases in the control group) and 486 601 cases of IBS samples (53 400 cases in the case group and 433 201 cases in the control group). The above samples were all from the European population. IVW was used as the main analysis method to test the causal relationship between GERD and IBS. IVW and MR-Egger methods were used to test heterogeneity, MR-Egger regression intercept was used to test pleiotropy, "leave one" method was used to test the sensitivity of the study, and F value was used to test whether there was weak instrumental variable bias.  Results  When GERD was selected as exposure and IBS was used as the outcome, 191 cases of SNPs were screened and included. Results indicated that GERD was a risk factor for the occurrence of IBS, and there was a certain causal relationship (IVW method: OR=1.328, 95% CI: 1.269-1.390, P < 0.05). Reverse MR analysis showed that IBS also increased the risk of GERD (IVW method: OR=1.453, 95% CI: 1.092-1.932, P < 0.05).  Conclusion  There is a bidirectional causal relationship between GERD and IBS. The GERD increases the risk of IBS, and IBS also has a positive effect on GERD.

     

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