Volume 24 Issue 2
Feb.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(2): 247-250
JIN Li, LYU Jing, WANG Xiaopei, LIANG Changna, LI Zhao, LU Wanhong. The predictive value of serum albumin changes at 1 year of peritoneal dialysis for the risk of death in peritoneal dialysis patients[J]. Chinese Journal of General Practice, 2026, 24(2): 247-250. doi: 10.16766/j.cnki.issn.1674-4152.004371
Citation: JIN Li, LYU Jing, WANG Xiaopei, LIANG Changna, LI Zhao, LU Wanhong. The predictive value of serum albumin changes at 1 year of peritoneal dialysis for the risk of death in peritoneal dialysis patients[J]. Chinese Journal of General Practice, 2026, 24(2): 247-250. doi: 10.16766/j.cnki.issn.1674-4152.004371
shu

The predictive value of serum albumin changes at 1 year of peritoneal dialysis for the risk of death in peritoneal dialysis patients

doi: 10.16766/j.cnki.issn.1674-4152.004371

  • Department of Nephrology, the First Affiliated Hospital of Xi ' an Jiaotong University, Xi ' an, Shaanxi 710061, China

Funds:

 2022JM-598

 XJTU1AF-CRF-2019-017

  • Received Date: 2025-03-24
    Available Online: 2026-04-11
    Abstract
  •   Objective  Hypoalbuminemia before dialysis affects the survival of peritoneal dialysis (PD) patients, but studies on the effect of albumin improvement on survival rate are limited. This study uses follow-up data to analyze the impact of changes in albumin (ALB) levels after one year of PD on patients ' prognosis.  Methods  A total of 356 PD patients who underwent new catheterization in the Department of Nephrology, the First Affiliated Hospital of Xi ' an Jiaotong University from January 2015 to December 2019 and received regular follow-up for more than 1 year were retrospectively analyzed. According to their ALB levels at baseline and during one year of dialysis, the patients were divided into continuous low ALB group (group A, n=66), ALB increased group (group B, n=113), ALB decreased group (group C, n=24), and continuous high ALB group (group D, n=153). The Kaplan-Meier method was used to compare the cumulative survival rate among different groups, and the Cox proportional hazards regression model was used to evaluate the risk of all-cause mortality.  Results  Compared with patients whose ALB ≥35 g/L at 1 year of peritoneal dialysis, those with an ALB level of < 35 g/L had significantly lower creatinine, haemoglobin, and handgrip strength levels, while their high-sensitivity C-reactive protein (hs-CRP) and peritoneal protein clearance levels were significantly higher. Multivariate stepwise logistic regression showed that initial high peritoneal protein clearance rate (OR=1.023, P < 0.001) and low grip strength (OR=0.947, P=0.020), high hs-CRP (OR=1.078, P=0.005), and edema (OR=2.447, P=0.001) were independent influencing factors for albumin < 35 g/L at 1 year of peritoneal dialysis. The Cox proportional hazards model showed that albumin < 35 g/L at 1 year of dialysis was an independent influencing factor for death in peritoneal dialysis patients (OR=3.164, P=0.001).  Conclusion  High peritoneal protein clearance and low handgrip strength in the first month of peritoneal dialysis, high hs-CRP levels and edema, are independent risk factors for predicting albumin < 35 g/L at 1 year of peritoneal dialysis. An increase in post-dialysis ALB can significantly reduce the mortality risk in peritoneal dialysis patients.

     

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