Volume 24 Issue 2
Feb.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(2): 259-261
FANG Fang, YE Long. The efficacy of Gufei Zhike Decoction combined with Montelukast Sodium in children with chronic cough and its influence on immune function and inflammation[J]. Chinese Journal of General Practice, 2026, 24(2): 259-261. doi: 10.16766/j.cnki.issn.1674-4152.004374
Citation: FANG Fang, YE Long. The efficacy of Gufei Zhike Decoction combined with Montelukast Sodium in children with chronic cough and its influence on immune function and inflammation[J]. Chinese Journal of General Practice, 2026, 24(2): 259-261. doi: 10.16766/j.cnki.issn.1674-4152.004374
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The efficacy of Gufei Zhike Decoction combined with Montelukast Sodium in children with chronic cough and its influence on immune function and inflammation

doi: 10.16766/j.cnki.issn.1674-4152.004374

  • Department of Traditional Chinese Pediatrics, Wenzhou Hospital of Integrated Chinese and Western Medicine, Wenzhou, Zhejiang 325000, China

Funds:

 2024ZL999

  • Received Date: 2025-03-18
    Available Online: 2026-04-11
    Abstract
  •   Objective  Attention should be paid to the lingering symptoms of chronic cough in children. This study analyzed the efficacy of Gufei Zhike Decoction combined with Montelukast sodium in the treatment of chronic cough in children (lung and spleen deficiency type) and the influence on immune function and inflammation.  Methods  A total of 180 children with chronic cough admitted to the Department of Pediatrics of Wenzhou Hospital of Integrated Chinese and Western Medicine from July 2023 to June 2024 were divided into the western medicine group (montelukast sodium) and the combined Chinese and Western medicine group (Gufei Zhike Decoction + montelukast sodium) by random number table method, with 90 cases each, with 1 month of treatment. The clinical efficacy, cough improvement, traditional Chinese medicine (TCM) syndrome score, immune function [immunoglobulin (IgG, IgM, IgA)], and inflammatory response [exhaled nitric oxide (FeNO), serum hypersensitive C-reactive protein (hs-CRP), and interleukin-4 (IL-4)] were compared between the two groups.  Results  The total effective rate of the combination group was higher than that of the western group [85.56% (77/90) vs. 70.00% (63/90), χ2=6.300, P=0.012]. The duration of cough remission and cough disappearance in the combined group was shorter than that in the western medicine group[(15.23±3.41) d vs. (18.47±3.65) d, (22.19±1.93) d vs. (24.86±2.05) d, P < 0.05]. After 1 month of treatment, TCM syndrome score, FeNO, hs-CRP, and IL-4 levels in both groups decreased, and the combined Chinese and Western medicine group was lower (P < 0.05), while the levels of IgG, IgM, and IgA in both groups increased, and the combined Chinese and Western medicine group was higher (P < 0.05).  Conclusion  Gufei Zhike Decoction combined with Montelukast sodium can effectively treat chronic cough in children, improve symptoms, improve immune function, and relieve inflammation.

     

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