Volume 24 Issue 2
Feb.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(2): 267-270
LUO Fugang, HE Xi, WU Yuejing. Effect of FKBP5 gene polymorphism on hair cortisol predicting suicidal intent in patients with depression[J]. Chinese Journal of General Practice, 2026, 24(2): 267-270. doi: 10.16766/j.cnki.issn.1674-4152.004376
Citation: LUO Fugang, HE Xi, WU Yuejing. Effect of FKBP5 gene polymorphism on hair cortisol predicting suicidal intent in patients with depression[J]. Chinese Journal of General Practice, 2026, 24(2): 267-270. doi: 10.16766/j.cnki.issn.1674-4152.004376
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Effect of FKBP5 gene polymorphism on hair cortisol predicting suicidal intent in patients with depression

doi: 10.16766/j.cnki.issn.1674-4152.004376

  • Mental Health Center Affiliated to Zhejiang University School of Medicine/Department of Psychiatry, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang 310000, China

Funds:

 2024KY1371

  • Received Date: 2025-02-17
    Available Online: 2026-04-11
    Abstract
  •   Objective  To analyze the impact of the rs1360780 polymorphism in the FKBP5 gene on the predictive value of hair cortisol levels for suicidal intention in patients with depression, and clarify factors related to suicidal intention and the clinical value of hair cortisol as an objective biomarker.  Methods  A total of 80 depressive patients with suicidal intention who were diagnosed and treated in Hangzhou Seventh People' s Hospital from May 2022 to May 2024 were selected as the observation group, and depressive patients without suicidal intention who had similar basic information, living habits and disease history were selected as the control group at a ratio of 1∶1. The Hamilton depression rating scale (HAMD), self-rating suicidal ideation scale (SIOSS), FKBP5 rs1360780 polymorphism, hair and serum cortisol levels of different patients were compared, and the risk factors of suicidal intent were analyzed.  Results  In rs1360780 CT/TT, rs1360780 CC and all patients, serum and hair cortisol levels were positively correlated with HAMD and SIOSS. Self-guilt (OR=2.568, 95% CI: 1.345-4.903), anxiety (OR=2.077, 95% CI: 1.313-3.286), despair (OR=1.024, 95% CI: 1.008-1.040), rs1360780 CT/TT (OR=3.831, 95% CI: 2.436-6.024), HAMD (OR=2.440, 95% CI: 1.847-3.223) and SIOSS (OR=1.506, 95% CI: 1.060-2.138) were significantly different.  Conclusion  The predictive value of hair cortisol levels in depression patients for depression suicide is influenced by the presence of the T allele FKBP5 rs1360780.

     

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    • References(20)
  • [1]
    牛静, 潘惟华, 王克, 等. 难治性抑郁症病人血浆非酶类抗氧化物和甲状腺激素水平分析[J]. 青岛大学学报(医学版), 2021, 57(5): 746-749.

    NIU J, PAN W H, WANG K, et al. Analysis of plasma non enzymatic antioxidants and thyroid hormone levels in patients with refractory depression[J]. Journal of Qingdao University(Medical Edition), 2021, 57(5): 746-749.
    [2]
    郑吉锋, 冯彩琴. 晚发性抑郁症患者抑郁程度与多导睡眠参数及疲劳水平的相关性[J]. 中华全科医学, 2024, 22(8): 1347-1349, 1419.

    ZHENG J F, FENG C Q. Correlation between depression degree, polysomnography parameters and fatigue level in patients with late-onset depression[J]. Chinese general practice, 2024, 22(8): 1347-1349, 1419.
    [3]
    王甜甜, 贾园园, 齐德仪, 等. 发病前头发中下丘脑-垂体-肾上腺轴激素水平与脑卒中后情绪障碍的相关性分析[J]. 康复学报, 2024, 34(3): 211-216.

    WANG T T, JIA Y Y, QI D Y, et al. Correlation analysis between hypothalamus pituitary adrenal axis hormone level in hair before onset and emotional disorder after stroke[J]. Journal of Rehabilitation, 2024, 34(3): 211-216.
    [4]
    AGAM G, ATAWNA B, DAMRI O, et al. The role of FKBPs in complex disorders: neuropsychiatric diseases, cancer, and type 2 diabetes mellitus[J]. Cells, 2024, 13(10): 801. DOI: 10.3390/cells13100801.
    [5]
    HENNINGS J M, ISING M, UHR M, et al. Recurrent suicide attempts affect normalization of HPA axis dysregulation after recovery from major depression[J]. Front Psychiatry, 2022, 13: 937582. DOI: 10.3389/fpsyt.2022.937582.
    [6]
    VALLE R. Validity, reliability and clinical utility of mental disorders: the case of ICD-11 schizophrenia[J]. Rev Colomb Psiquiatr (Engl Ed), 2022, 51(1): 61-70.
    [7]
    VALERIO M P, LOMASTRO J, IGOA A, et al. Neurocognitive function of patients with melancholic and non-melancholic major depressive episodes: an exploratory study[J]. Aust N Z J Psychiatry, 2023, 57(7): 1023-1030. doi: 10.1177/00048674221133743
    [8]
    LUO Y Y, LAI Q L, HUANG H, et al. Risk factor analysis and nomogram construction for predicting suicidal ideation in patients with cancer[J]. BMC Psychiatry, 2022, 22(1): 353. DOI: 10.1186/s12888-022-03987-z.
    [9]
    ZITSER J, ALLEN I E, FALGÀS N, et al. Pittsburgh Sleep Quality Index (PSQI) responses are modulated by total sleep time and wake after sleep onset in healthy older adults[J]. PLoS One, 2022, 17(6): e0270095. DOI: 10.1371/journal.pone.0270095.
    [10]
    赵众, 周刚, 黄耀明, 等. 利用机器学习算法精简焦虑和抑郁自评量表[J]. 精神医学杂志, 2022, 35(5): 466-471.

    ZHAO Z, ZHOU G, HUANG Y M, et al. Using machine learning algorithm to simplify the self rating anxiety and depression scale[J]. Journal of Psychiatry, 2023, 36(5): 466-471.
    [11]
    SONG J, LIU Y D, GUO Y, et al. TMEM173 rs7447927 genetic polymorphism and susceptibility to severe enterovirus 71 infection in Chinese children[J]. Immun Inflamm Dis, 2022, 10(12): e742. DOI: 10.1002/iid3.742.
    [12]
    IGBOANUGO S, O' CONNOR C, ZITOUN O A, et al. A systematic review of hair cortisol in healthy adults measured using immunoassays: methodological considerations and proposed reference values for research[J]. Psychophysiology, 2024, 61(1): e14474. DOI: 10.1111/psyp.14474.
    [13]
    DAVILA-CERVANTES C A, LUNA-CONTRERAS M. Suicide attempts in the adult mexican population: an analysis of sociodemographic characteristics and associated factors[J]. Rev Bras Epidemiol, 2024, 27: e240014. DOI: 10.1590/1980-549720240014.
    [14]
    SHARMA R, TIKKA S K, YADAV A K, et al. Cerebrospinal fluid monoamine metabolite concentrations in suicide attempt: a meta-analysis[J]. Asian J Psychiatr, 2021, 62: 102711. DOI: 10.1016/j.ajp.2021.102711.
    [15]
    JAMSHIDI E, BOSTRÖM A E D, WILCZEK A, et al. Increased methylation of brain-derived neurotrophic factor (BDNF) is related to emotionally unstable personality disorder and severity of suicide attempt in women[J]. Cells, 2023, 12(3): 350. DOI: 10.3390/cells12030350.
    [16]
    MLILI N E, AHABRACH H, CAULI O. Hair cortisol concentration as a biomarker of symptoms of depression in the perinatal period[J]. CNS Neurol Disord Drug Targets, 2023, 22(1): 71-83. doi: 10.2174/1871527321666220316122605
    [17]
    NYSTRÖM-HANSEN M, ANDERSEN M S, DAVIDSEN K A, et al. Hair cortisol concentrations in pregnant women with bipolar, depressive, or schizophrenic spectrum disorders[J]. Arch Womens Ment Health, 2024, 27(4): 577-584. doi: 10.1007/s00737-024-01434-4
    [18]
    HERNÁNDEZ-DÍAZ Y, GONZÁLEZ-CASTRO T B, TOVILLA-ZÁRATE C A, et al. Association between polymorphisms of FKBP5 gene and suicide attempt in a Mexican population: a case-control study[J]. Brain Res Bull, 2021, 166: 37-43. doi: 10.1016/j.brainresbull.2020.11.002
    [19]
    MATOSIN N, ARLOTH J, CZAMARA D, et al. Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex[J]. Acta Neuropathol, 2023, 145(4): 439-459. doi: 10.1007/s00401-023-02541-9
    [20]
    DIONISIO-GARCÍA D M, GENIS-MENDOZA A D, GONZÁLEZ-CASTRO T B, et al. DNA methylation of genes involved in the HPA axis in presence of suicide behavior: a systematic review[J]. Brain Sci, 2023, 13(4): 584. DOI: 10.3390/brainsci13040584.
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