Volume 24 Issue 2
Feb.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(2): 289-293
WANG Yanan, ZHANG Jinpeng, XIA Meihui, REN Qianyi, HAN Xinhui, LIANG Guoying. Research progress on the mechanism of traditional Chinese medicine in the prevention and treatment of non-alcoholic fatty liver disease[J]. Chinese Journal of General Practice, 2026, 24(2): 289-293. doi: 10.16766/j.cnki.issn.1674-4152.004381
Citation: WANG Yanan, ZHANG Jinpeng, XIA Meihui, REN Qianyi, HAN Xinhui, LIANG Guoying. Research progress on the mechanism of traditional Chinese medicine in the prevention and treatment of non-alcoholic fatty liver disease[J]. Chinese Journal of General Practice, 2026, 24(2): 289-293. doi: 10.16766/j.cnki.issn.1674-4152.004381
shu

Research progress on the mechanism of traditional Chinese medicine in the prevention and treatment of non-alcoholic fatty liver disease

doi: 10.16766/j.cnki.issn.1674-4152.004381
  • 1.

    Graduate School of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China

Funds:

 ZHY2024-185

  • Received Date: 2025-04-30
    Available Online: 2026-04-11
    Abstract
  • The incidence of Non-alcoholic fatty liver disease (NAFLD) has increased markedly and it has become a global health issue. NAFLD is characterized by an abnormal accumulation of fat in hepatocytes and is a metabolic disorder with a complex pathological mechanism closely related to insulin resistance, endoplasmic reticulum stress, mitochondrial dysfunction, oxidative stress, autophagy and abnormal gut microbiota. At present, Western medicine has not identified a specific pharmaceutical treatment for NAFLD, whereas traditional Chinese medicine (TCM) has demonstrated unique advantages and significant potential in the prevention and treatment of NAFLD. According to TCM, the fundamental cause of the disease lies in the liver' s inability to maintain adequate dispersion and dredging function and the spleen' s incapacity to carry out its normal transportation and transformation processes. This results in the complex interplay of phlegm-dampness and blood stasis, which impede the liver collaterals, leading to causing the accumulation of turbid and fatty qi within the liver. With regard to the treatment of this condition, the fundamental principles are to soothe the liver and strengthen the spleen, as well as to resolve turbidity and remove stasis. In recent years, a significant number of studies have concentrated on the mechanism of action of TCM compound prescriptions, single herbs and active ingredients, revealing the core pathways through which they effectively intervene in the progression of NAFLD through multi-target and multi-pathway coordinated regulation. However, there is a paucity of comprehensive review articles on the mechanism of TCM in the prevention and treatment of NAFLD. This review systematically integrates the latest research results of TCM in the prevention and treatment of NAFLD, and carries out a profound analysis of its multi-level and multi-target action mechanisms at the molecular, cellular, and system levels based on a holistic view and the principle of syndrome differentiation and treatment. This provides a unique perspective for a deeper understanding of the complex pathogenesis network of NAFLD, as well as provides a solid theoretical basis and important research direction for the precise clinical application of TCM and the development of innovative therapies based on traditional Chinese medicine.

     

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