Volume 24 Issue 3
Mar.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(3): 362-374
General Practice Branch of Cross-Straits Medicine Exchange Association, General Practice Branch of Zhejiang Medical Association, Medically Unspecified Disease Professional Committee of Zhejiang Society for Mathematical Medicine, the Expert Collaboration Group on, Medically Unspecified Disease in General Practice, Chinese Geriatrics Society. Expert consensus on the diagnosis, treatment, and management of abnormal creatine kinase (2025)[J]. Chinese Journal of General Practice, 2026, 24(3): 362-374. doi: 10.16766/j.cnki.issn.1674-4152.004398
Citation: General Practice Branch of Cross-Straits Medicine Exchange Association, General Practice Branch of Zhejiang Medical Association, Medically Unspecified Disease Professional Committee of Zhejiang Society for Mathematical Medicine, the Expert Collaboration Group on, Medically Unspecified Disease in General Practice, Chinese Geriatrics Society. Expert consensus on the diagnosis, treatment, and management of abnormal creatine kinase (2025)[J]. Chinese Journal of General Practice, 2026, 24(3): 362-374. doi: 10.16766/j.cnki.issn.1674-4152.004398
shu

Expert consensus on the diagnosis, treatment, and management of abnormal creatine kinase (2025)

doi: 10.16766/j.cnki.issn.1674-4152.004398
Funds:

 72274169

  • Received Date: 2025-10-10
    Available Online: 2026-06-02
    Abstract
  • Abnormal creatine kinase (CK) levels represent a prevalent clinical problem with diverse and complex etiologies, for which systematic clinical research evidence remains limited. This condition not only adversely affects patients' physical and mental health but also imposes a substantial economic burden on society. This consensus statement was collaboratively drafted by multidisciplinary panel of experts in general practice, cardiovascular disease, and laboratory medicine. It provides a comprehensive overview of the definition, classification, epidemiology, etiology, and pathophysiological mechanisms underlying CK abnormalities. Furthermore, it elaborates on standardized diagnostic strategies, encompassing patient history-taking, physical examinations, and appropriate auxiliary assessments. Additionally, individualized treatment principles and specific therapeutic measures for CK abnormalities are systematically outlined. The consensus also underscores the importance of comprehensive community-based management strategies for CK abnormalities, including screening, risk assessment, follow-up care, tiered referral systems, and health education. Moreover, it proposes future directions for the diagnosis, treatment, and management of CK abnormalities, drawing on the applications of artificial intelligence and precision medicine in CK diagnostics and therapeutics. The ultimate goal is to offer guidance for the standardized diagnosis, treatment, and holistic management of CK abnormalities in clinical practice.

     

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  • [1]
    KYRIAKIDES T, ANGELINI C, SCHAEFER J, et al. EFNS guidelines on the diagnostic approach to pauci-or asymptomatic hyperCKemia[J]. Eur J Neurol, 2010, 17(6): 767-773. doi: 10.1111/j.1468-1331.2010.03012.x
    [2]
    尚红, 王毓三, 申子瑜. 全国临床检验操作规程[M]. 4版. 北京: 人民卫生出版社, 2015: 287-288, 398-399.

    SHANG H, WANG Y S, SHEN Z Y. National Clinical Laboratory Procedures[M]. 4th ed. Beijing: People's Medical Publishing House, 2015: 287-288, 398-399.
    [3]
    国家卫生和计划生育委员会. 临床常用生化检验项目参考区间第7部分: 血清乳酸脱氢酶、肌酸激酶: WS/T 404.7-2015[S]. 北京: 中国标准出版社, 2015.

    National Health and Family Planning Commission of the People's Republic of China. Clinical Common Biochemical Test Items Reference Intervals—Part 7: Serum Lactate Dehydrogenase, Creatine Kinase: WS/T 404.7-2015[S]. Beijing: Standards Press of China, 2015.
    [4]
    吉林省卫生健康委员会. 0~3天新生儿血清乳酸脱氢酶; 肌酸激酶; 肌酸激酶同工酶MB参考区间: DB22/T 3164-2020[S]. 2020.

    Jilin Provincial Health Commission. Reference Intervals of Serum Lactate Dehydrogenase, Creatine Kinase and Creatine Kinase Isoenzyme MB for Neonates Aged 0-3 Days: DB22/T 3164-2020[S]. 2020.
    [5]
    万学红, 卢雪峰. 诊断学[M]. 10版. 北京: 人民卫生出版社, 2024: 374-375.

    WAN X H, LU X F. Diagnostics[M]. 10th ed. Beijing: People's Medical Publishing House, 2024: 374-375.
    [6]
    VENANCE S L. Approach to the patient with hyperCKemia[J]. Continuum(Minneap Minn), 2016, 22(6): 1803-1814.
    [7]
    班努·库肯, 吐尔逊·阿克木. 某三甲医院527例肌酸激酶升高病因构成和特点分析[J]. 临床合理用药杂志, 2020, 13(9): 173-175.

    Bannu·Kuken, Aerxu·Akmu. Etiological composition and characteristics analysis of elevated creatine kinase in 527 cases from a tertiary grade a hospital[J]. Journal of Clinical Rational Drug Use, 2020, 13(9): 173-175.
    [8]
    袁玉静, 刘畅, 谢志颖, 等. 无症状和轻症高肌酸激酶血症临床及组织病理学特征分析[J]. 中国现代神经疾病杂志, 2023, 23(9): 782-788.

    YUAN Y J, LIU C, XIE Z Y, et al. Clinical and histopathological characteristics of asymptomatic and mild hypercreatinemia[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2023, 23(9): 782-788.
    [9]
    郑晓仙. 生化检测中肌酸激酶同工酶高于肌酸激酶的原因分析[J]. 吉林医学, 2024, 45(5): 1093-1096.

    ZHENG X X. Analysis of causes of creatine kinase isoenzyme higher than creatine kinase in biochemical tests [J]. Jilin Medical Journal, 2024, 45(5): 1093-1096.
    [10]
    GEORGE M D, MCGILL N K, BAKER J F. Creatine kinase in the U.S. population: impact of demographics, comorbidities, and body composition on the normal range[J]. Medicine (Baltimore), 2016, 95(33): e4344. DOI: 10.1097/MD.0000000000004344.
    [11]
    MAHMUTYAZICIOGLU J, NASH J, CLEVES A, et al. Is it necessary to adjust current creatine kinase reference ranges to reflect levels found in professional footballers?[J]. BMJ Open Sport Exerc Med, 2018, 4(1): e000282. DOI: 10.1136/bmjsem-2017-000282.
    [12]
    PANG X R, GE M. Effect of geographical factors on reference values of creatine kinase isoenzyme[J]. Int J Biometeorol, 2023, 67(4): 553-563. doi: 10.1007/s00484-023-02429-z
    [13]
    ZHANG Y, ZHENG P, SHI J Q, et al. Associations of ambient temperature with creatine kinase MB and creatine kinase: a large sample time series study of the Chinese male population[J]. Sci Total Environ, 2023, 880: 163250. DOI: 10.1016/j.scitotenv.2023.163250.
    [14]
    MOGHADAM-KIA S, ODDIS C V, AGGARWAL R. Approach to asymptomatic creatine kinase elevation[J]. Cleve Clin J Med, 2016, 83(1): 37-42. doi: 10.3949/ccjm.83a.14120
    [15]
    ALEKSOVSKA K, KYRIAKIDES T, ANGELINI C, et al. What are the normal serum creatine kinase values for skeletal muscle? A worldwide systematic review[J]. Eur J Neurol, 2025, 32(6): e70240. DOI: 10.1111/ene.70240.
    [16]
    MUSAI J, MAMMEN A L, PINAL-FENANDEZ I. Recent updates on the pathogenesis of inflammatory myopathies[J]. Curr Rheumatol Rep, 2024, 26(12): 421-430. doi: 10.1007/s11926-024-01164-7
    [17]
    PUELACHER C, GUALANDRO D M, GLARNER N, et al. Long-term outcomes of perioperative myocardial infarction/injury after non-cardiac surgery[J]. Eur Heart J, 2023, 44(19): 1690-1701. doi: 10.1093/eurheartj/ehac798
    [18]
    张颖. 肌钙蛋白Ⅰ、肌红蛋白和肌酸激酶同工酶检测在急性心肌梗死诊断中的价值[J]. 中国实用医刊, 2019, 46(11): 43-45.

    ZHANG Y. Value of troponin I, myoglobin and creatine kinase isoenzyme MB detection in the diagnosis of acute myocardial infarction[J]. Chinese Journal of Practical Medicine, 2019, 46(11): 43-45.
    [19]
    中华医学会心血管病学分会, 中华心血管病杂志编辑委员会. 非ST段抬高型急性冠脉综合征诊断和治疗指南(2024)[J]. 中华心血管病杂志, 2024, 52(6): 615-646.

    Chinese Society Of Cardiology, Chinese Medical Association; Editorial Board Of Chinese Journal Of Cardiology. Guidelines for the Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndrome (2024)[J]. Chinese Journal of Cardiology, 2024, 52(6): 615-646.
    [20]
    李岳华, 黄洁. 心肌炎的诊断、治疗与预后[J]. 中华心力衰竭和心肌病杂志, 2022, 6(4): 330-334.

    LI Y H, HUANG J. Diagnosis, treatment and prognosis of myocarditis[J]. Chinese Journal of Heart Failure and Cardiomyopathy, 2022, 6(4): 330-334.
    [21]
    吕和平, 倪海真, 黄景勇, 等. 肌酸激酶及CT血管造影检查评估肠系膜上动脉栓塞的短期预后[J]. 中华消化外科杂志, 2016, 15(8): 840-844.

    LYU H P, NI H Z, HUANG J Y, et al. Evaluation of short-term prognosis of superior mesenteric artery embolism by creatine kinase and CT angiography[J]. Chinese Journal of Digestive Surgery, 2016, 15(8): 840-844.
    [22]
    王渭鉴, 陈慧. 甲状腺功能减退相关性肌酸激酶升高的研究进展[J]. 国际检验医学杂志, 2024, 45(9): 1141-1144, 1152.

    WANG W J, CHEN H. Research progress on elevated creatine kinase associated with hypothyroidism[J]. International Journal of Laboratory Medicine, 2024, 45(9): 1141-1144, 1152.
    [23]
    DÍAZ-LÓPEZ E J, VILLAR-TAIBO R, RODRIGUEZ-CARNERO G, et al. Should we suspect primary aldosteronism in patients with hypokalaemic rhabdomyolysis? A systematic review[J]. Front Endocrinol, 2023, 14: 1257078. DOI: 10.3389/fendo.2023.1257078.
    [24]
    柳彬彬, 母玉洁, 张琨, 等. 糖尿病酮症酸中毒合并高渗高血糖状态致横纹肌溶解1例[J]. 中华糖尿病杂志, 2022, 14(9): 977-979.

    LIU B B, MU Y J, ZHANG K, et al. A case of rhabdomyolysis caused by diabetic ketoacidosis complicated with hyperosmolar hyperglycemic state[J]. Chinese Journal of Diabetes Mellitus, 2022, 14(9): 977-979.
    [25]
    中华医学会神经病学分会, 中华医学会神经病学分会神经肌肉病学组. 成人晚发型糖原累积病Ⅱ型(蓬佩病)诊疗中国专家共识[J]. 中华神经科杂志, 2021, 54(10): 994-1000.

    Chinese Society of Neurology, Chinese Medical Association; Neuromuscular Disease Group, Chinese Society Of Neurology. Chinese Expert Consensus on Diagnosis and Treatment of Adult Late-Onset Glycogen Storage Disease Type Ⅱ (Pompe Disease)[J]. Chinese Journal of Neurology, 2021, 54(10): 994-1000.
    [26]
    中华医学会神经病学分会, 中华医学会神经病学分会神经肌肉病学组, 中华医学会神经病学分会肌电图及临床神经生理学组. 中国脂质沉积性肌病诊治专家共识[J]. 中华神经科杂志, 2015, 48(11): 941-945.

    Chinese Society of Neurology, Chinese Medical Association; Neuromuscular Disease Group, Chinese Society of Neurology; Electromyography And Clinical Neurophysiology Group, Chinese Society of Neurology. Chinese Expert Consensus on Diagnosis and Treatment of Lipid Storage Myopathy[J]. Chinese Journal of Neurology, 2015, 48(11): 941-945.
    [27]
    WEN H P, DENG H, LI B Y, et al. Mitochondrial diseases: from molecular mechanisms to therapeutic advances[J]. Signal Transduct Target Ther, 2025, 10: 9. DOI: 10.1038/s41392-024-02044-3.
    [28]
    张彦, 邱文娟, 张惠文, 等. 六例肉碱棕榈酰基转移酶2缺乏症患儿临床特征及基因变异分析[J]. 浙江大学学报(医学版), 2024, 53(2): 207-212.

    ZHANG Y, QIU W J, ZHANG H W, et al. Clinical characteristics and genetic variation analysis of six children with carnitine palmitoyltransferase 2 deficiency[J]. Journal of Zhejiang University (Medical Sciences), 2024, 53(2): 207-212.
    [29]
    TWAYANA S, SHARMA V K, RAUT M, et al. Mean serum creatine kinase among organophosphate poisoning cases in a tertiary care centre: a descriptive cross-sectional study[J]. JNMA J Nepal Med Assoc, 2022, 60(254): 881-883. doi: 10.31729/jnma.7692
    [30]
    CALLEN J P. Relationship of cancer to inflammatory muscle diseases. Dermatomyositis, polymyositis, and inclusion body myositis[J]. Rheum Dis Clin North Am, 1994, 20(4): 943-953. doi: 10.1016/S0889-857X(21)00074-0
    [31]
    MAMMEN A L. Paraneoplastic myopathies[J]. Handb Clin Neurol, 2024, 200: 327-332.
    [32]
    HILL C L, ZHANG Y, SIGURGEIRSSON B, et al. Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study[J]. Lancet, 2001, 357(9250): 96-100. doi: 10.1016/S0140-6736(00)03540-6
    [33]
    HASSELGREN P O, FISCHER J E. Muscle cachexia: current concepts of intracellular mechanisms and molecular regulation[J]. Ann Surg, 2001, 233(1): 9-17. doi: 10.1097/00000658-200101000-00003
    [34]
    GAO F Y, XU T, ZANG F N, et al. Cardiotoxicity of anticancer drugs: molecular mechanisms, clinical management and innovative treatment[J]. Drug Des Devel Ther, 2024, 18: 4089-4116. doi: 10.2147/DDDT.S469331
    [35]
    常杏芝. 先天性肌病的诊断与治疗[J]. 中华实用儿科临床杂志, 2016, 31(12): 881-883.

    CHANG X Z. Diagnosis and treatment of congenital myopathies[J]. Chinese Journal of Applied Clinical Pediatrics, 2016, 31(12): 881-883.
    [36]
    LEIVA-CEPAS F, MONTAÑO MARTÍNEZ A, et al. Update on Duchenne muscular dystrophy[J]. Semergen, 2021, 47(7): 472-481. doi: 10.1016/j.semerg.2021.06.008
    [37]
    唐亮, 陈晓晴, 谭伟强, 等. 应用血肌酸激酶或肌酸激酶MM同工酶筛查新生儿杜氏肌营养不良症的系统评价/Meta分析[J]. 中国循证儿科杂志, 2022, 17(5): 343-349.

    TANG L, CHEN X Q, TAN W Q, et al. Systematic review/meta-analysis of serum creatine kinase or creatine kinase MM isoenzyme for screening neonatal duchenne muscular dystrophy[J]. Chinese Journal of Evidence-Based Pediatrics, 2022, 17(5): 343-349.
    [38]
    HONG K N, ESHRAGHIAN E A, ARAD M, et al. International consensus on differential diagnosis and management of patients with Danon disease: JACC state-of-the-art review[J]. J Am Coll Cardiol, 2023, 82(16): 1628-1647. doi: 10.1016/j.jacc.2023.08.014
    [39]
    YANG B F, LI D, LIU C L, et al. Advances in rhabdomyolysis: a review of pathogenesis, diagnosis, and treatment[J]. Chin J Traumatol, 2025: S1008-S1275(25)00010-0. DOI: 10.1016/j.cjtee.2024.10.005.
    [40]
    MASTAGLIA F L. The changing spectrum of drug-induced myopathies[J]. Acta Myol, 2020, 39(4): 283-288.
    [41]
    COUTINHO A, FONSECA N, NOVO I, et al. Corticosteroid-induced myopathy[J]. Cureus, 2023, 15(11): e49548. DOI: 10.7759/cureus.49548.
    [42]
    OSTROWSKI P, BONCZAR M, AVRAM A E, et al. Safety monitoring of drug-induced muscle injury and rhabdomyolysis: a biomarker-guided approach for clinical practice and drug trials[J]. Clin Chem Lab Med, 2023, 61(10): 1688-1699. doi: 10.1515/cclm-2023-0313
    [43]
    MATÉ-MUÑOZ J L, LOUGEDO J H, BARBA M, et al. Cardiometabolic and muscular fatigue responses to different CrossFit® workouts[J]. J Sports Sci Med, 2018, 17(4): 668-679.
    [44]
    ALZUETA N, MARIN M, CASTRESANA M, et al. Statin-induced autoimmune myopathy: a case report[J]. Eur J Hosp Pharm, 2021, 28(2): 115-117. doi: 10.1136/ejhpharm-2019-002102
    [45]
    MARTI P, PITARCH-CASTELLANO I, MUELAS N, et al. Asymptomatic hyperCKemia in the pediatric population: a prospective study utilizing next-generation sequencing and ancillary tests[J/OL]. Neurology, 2025, 104(1): e210116. DOI: 10.1212/WNL.0000000000210116.
    [46]
    SILVESTRI N J, WOLFE G I. Asymptomatic/pauci-symptomatic creatine kinase elevations (hyperCKemia)[J]. Muscle Nerve, 2013, 47(6): 805-815. doi: 10.1002/mus.23755
    [47]
    李建萍. 轻微症状/无症状高肌酸激酶血症诊断方法指南解读及最新进展[J]. 神经病学与神经康复学杂志, 2016, 12(2): 64-70.

    LI J P. Interpretation of guidelines for diagnostic methods and latest progress in mild/asymptomatic hypercreatinemia[J]. Journal of Neurology and Neurorehabilitation, 2016, 12(2): 64-70.
    [48]
    ECHANIZ-LAGUNA A, LORNAGE X, LAFORET P, et al. A new glycogen storage disease caused by a dominant PYGM mutation[J]. Ann Neurol, 2020, 88(2): 274-282. doi: 10.1002/ana.25771
    [49]
    BOUGHDAD S, LATIFYAN S, FENWICK C, et al. 68Ga-DOTATOC PET/CT to detect immune checkpoint inhibitor-related myocarditis[J]. J Immunother Cancer, 2021, 9(10): e003594. DOI: 10.1136/jitc-2021-003594.
    [50]
    GAUDINO M, JAFFE A S, MILOJEVIC M, et al. Great debate: myocardial infarction after cardiac surgery must be redefined[J]. Eur Heart J, 2024, 45(39): 4170-4177. doi: 10.1093/eurheartj/ehae416
    [51]
    MARZOLA F, VAN ALFEN N, DOORDUIN J, et al. Deep learning segmentation of transverse musculoskeletal ultrasound images for neuromuscular disease assessment[J]. Comput Biol Med, 2021, 135: 104623. DOI: 10.1016/j.compbiomed.2021.104623.
    [52]
    RAYNER J J, PETERZAN M A, CLARKE W T, et al. Obesity modifies the energetic phenotype of dilated cardiomyopathy[J]. Eur Heart J, 2021, 43(9): 868-877.
    [53]
    MIGLIORE B A, ZHOU L R, DUPARC M, et al. Evaluation of the GSP creatine kinase-MM assay and assessment of CK-MM stability in newborn, patient, and contrived dried blood spots for newborn screening for Duchenne muscular dystrophy[J]. Int J Neonatal Screen, 2022, 8(1): 12. DOI: 10.3390/ijns8010012.
    [54]
    PARK S, MALONEY B, CAGGANA M, et al. Creatine kinase-MM concentration in dried blood spots from newborns and implications for newborn screening for Duchenne muscular dystrophy[J]. Muscle and Nerve, 2022, 65(6): 652-658. doi: 10.1002/mus.27533
    [55]
    GOZDE KANMAZ KUTMAN H, KADIOGLU ŞIMSEK G, CERAN B, et al. Troponin I, CK-MB, and inotropic score in hypoxic-ischemic encephalopathy and associated infant mortality[J]. BMC Pediatrics, 2023, 23(1): 511. DOI: 10.1186/s12887-023-04311-8.
    [56]
    蔡科达, 郑晓彤, 林智摸, 等. 岭南头皮针对小儿脑瘫患者血清VEGF、CK-BB及运动功能的影响[J/OL]. 中华中医药学刊, 2025: 1-7. (2025-07-04). [2025-11-23]. https://link.cnki.net/urlid/21.1546.R.20250704.1521.014.html.

    CAI K D, ZHENG X T, LIN Z M, et al. Effect of lingnan scalp acupuncture on serum VEGF, CK-BB and motor function in children with cerebral palsy[J/OL]. Chinese Archives of Traditional Chinese Medicine, 2025: 1-7. (2025-07-04). [2025-11-23]. https://link.cnki.net/urlid/21.1546.R.20250704.1521.014.html.
    [57]
    MAJAVA E, RENKO M, KUITUNEN I. Benign acute childhood myositis: a scoping review of clinical presentation and viral etiology[J]. Eur J Pediatr, 2024, 183(11): 4641-4647. doi: 10.1007/s00431-024-05786-y
    [58]
    SAAD F A, SICILIANO G, ANGELINI C. Advances in dystrophinopathy diagnosis and therapy[J]. Biomolecules, 2023, 13(9): 1319. DOI: 10.3390/biom13091319.
    [59]
    陈曦, 邹琪, 张新超, 等. 老年人横纹肌溶解症的临床特点及病因分析[J]. 中华老年医学杂志, 2021, 40(1): 87-91.

    CHEN X, ZOU Q, ZHANG X C, et al. Clinical characteristics and etiological analysis of rhabdomyolysis in the elderly[J]. Chinese Journal of Gerontology, 2021, 40(1): 87-91.
    [60]
    JEHLE D V, SCHULTZ H, KHATRI R, et al. Creatine kinase elevations and risk of renal failure and dialysis in patients with rhabdomyolysis[J/OL]. Cureus, 2025[2025-09-03]. https://pubmed.ncbi.nlm.nih.gov/40698228/.
    [61]
    王雨婷, 何燕, 王爱玲. 适度有氧运动联合放松训练对妊娠期高血压患者的影响[J]. 心理月刊, 2025, 20(12): 187-189.

    WANG Y T, HE Y, WANG A L. Effect of moderate aerobic exercise combined with relaxation training on patients with hypertensive disorder complicating pregnancy[J]. Psychological Monthly, 2025, 20(12): 187-189.
    [62]
    MARRUFO-GALLEGOS K C, VILLAFAN-BERNAL J R, ESPINO-Y-SOSA S, et al. Influential serum kinases (non-sFlt-1) and phosphatases in preeclampsia: systemic review and metanalysis[J/OL]. Int J Mol Sci, 2023, 24(16): 12842. DOI: 10.3390/ijms241612842.
    [63]
    BAEZA-TRINIDAD R. Rhabdomyolysis: a syndrome to be considered[J]. Med Clin (Barc), 2022, 158(6): 277-283. doi: 10.1016/j.medcli.2021.09.025
    [64]
    PEARSON A G, HIND K, MACNAUGHTON L S. The impact of dietary protein supplementation on recovery from resistance exercise-induced muscle damage: a systematic review with meta-analysis[J]. Eur J Clin Nutr, 2023, 77(8): 767-783. doi: 10.1038/s41430-022-01250-y
    [65]
    XIAO F Y, KABACHKOVA A V, JIAO L, et al. Effects of cold water immersion after exercise on fatigue recovery and exercise performance: meta analysis[J]. Front Physiol, 2023, 14: 1006512. DOI: 10.3389/fphys.2023.1006512.
    [66]
    葛均波, 王辰, 王建安. 内科学[M]. 10版. 北京: 人民卫生出版社, 2024.

    GE J B, WANG C, WANG J A. Internal Medicine[M]. 10th ed. Beijing: People's Medical Publishing House, 2024.
    [67]
    朱佳宏, 刘颖, 任菁菁. 以乏力为表现的未分化疾病全科诊疗思路[J]. 中华全科医学, 2023, 21(4): 539-543. doi: 10.16766/j.cnki.issn.1674-4152.002926

    ZHU J H, LIU Y, REN J J. General practice diagnosis and treatment thinking of undifferentiated diseases presenting with fatigue[J]. Chinese Journal of General Practice, 2023, 21(4): 539-543. doi: 10.16766/j.cnki.issn.1674-4152.002926
    [68]
    张渝婧, 仉培臻, 奉飘, 等. 脾肾阳虚型慢性疲劳综合征的中医治疗研究进展[J]. 长春中医药大学学报, 2024, 40(10): 1156-1161.

    ZHANG Y J, ZHANG P Z, FENG P, et al. Research progress of Traditional Chinese Medicine treatment for chronic fatigue syndrome of spleen-kidney Yang Deficiency Type[J]. Journal of Changchun University of Chinese Medicine, 2024, 40(10): 1156-1161.
    [69]
    EDWARDS V, VARI C, ROSE M, et al. Participant experiences of guided self-help acceptance and commitment therapy for improving quality of life in muscle disease: a nested qualitative study within the ACTMus randomized controlled trial[J]. Front Psychol, 2023, 14: 1233526. DOI: 10.3389/fpsyg.2023.1233526.
    [70]
    BLUM J, EPSTEIN R, WATTS S, et al. Importance of nutrient availability and metabolism for skeletal muscle regeneration[J]. Front Physiol, 2021, 12: 696018. DOI: 10.3389/fphys.2021.696018.
    [71]
    HIGGINS M R, IZADI A, KAVIANI M. Antioxidants and exercise performance: with a focus on vitamin E and C supplementation[J]. Int J Environ Res Public Health, 2020, 17(22): 8452. DOI: 10.3390/ijerph17228452.
    [72]
    PRADO C M, LANDI F, CHEW S T H, et al. Advances in muscle health and nutrition: a toolkit for healthcare professionals[J]. Clin Nutr, 2022, 41(10): 2244-2263.
    [73]
    中国血脂管理指南修订联合专家委员会. 中国血脂管理指南(基层版2024年)[J]. 中华心血管病杂志, 2024, 52(4): 330-337.

    Chinese Lipid Management Guideline Revision Joint Expert Committee, WANG Z W, LI J J, et al. Chinese Guidelines for Lipid Management (Primary Care Version 2024)[J]. Chinese Journal of Cardiology, 2024, 52(4): 330-337.
    [74]
    CHEN Q, ZHANG J, FENG H, et al. An update on statins: pleiotropic effect performed in intracerebral hemorrhage[J]. Atherosclerosis, 2019, 284: 264-265. doi: 10.1016/j.atherosclerosis.2019.01.020
    [75]
    SHAIKH S, GONZALEZ-ZAPATA A, MUJEEB A, et al. Asymptomatic hyperCKemia: a diagnostic trap[J]. Cureus, 2021, 13(1): e12791. DOI: 10.7759/cureus.12791.
    [76]
    SHEHATA R S, RADWAN N A, BAKRY H M, et al. Assessment of serum CK-MM level as a bioindicator for work-related musculoskeletal injuries among emergency hospital workers[J]. Toxicol Ind Health, 2022, 38(1): 11-18. doi: 10.1177/07482337211042727
    [77]
    庄红艳, 刘珊珊, 杜海霞, 等. 临床药师对1例喹硫平致肌酸激酶重度升高不良反应的监护[J]. 中国药师, 2019, 22(4): 702-704.

    ZHUANG H Y, LIU S S, DU H X, et al. Monitoring of severe elevation of creatine kinase induced by quetiapine: a case report by clinical pharmacists[J]. Chinese Pharmacist, 2019, 22(4): 702-704.
    [78]
    KIM E J, WIERZBICKI A S. Investigating raised creatine kinase[J]. BMJ, 2021, 373: n1486. DOI: 10.1136/bmj.n1486.
    [79]
    GEMELLI C, TRAVERSO M, TREVISAN L, et al. An integrated approach to the evaluation of patients with asymptomatic or minimally symptomatic hyperCKemia[J]. Muscle Nerve, 2022, 65(1): 96-104. doi: 10.1002/mus.27448
    [80]
    KANU I M, SULE P C, CHUKWURAH U A, et al. Enhancing health outcomes through community-based health education programs for underserved populations[J]. World J Adv Res Rev, 2024, 24(3): 3260-3283.
    [81]
    冯丽丽, 李芳芳, 郑秀, 等. 健康宣教清单在骨科创伤患者中的应用效果研究[J]. 中国现代医药杂志, 2023, 25(5): 75-78.

    FENG L L, LI F F, ZHENG X, et al. Study on the application effect of health education checklist in orthopedic trauma patients[J]. Chinese Journal of Modern Medicine, 2023, 25(5): 75-78.
    [82]
    陈春梅, 徐奕胜, 邹春生. 血清CK-MB、NT-proBNP、Cys C联合检测在尿毒症合并心力衰竭中的诊断价值[J]. 中国医学创新, 2025, 22(15): 146-150.

    CHEN C M, XU Y S, ZOU C S. Diagnostic value of combined detection of serum CK-MB, NT-proBNP and Cys C in uremia complicated with heart failure[J]. Chinese Medical Innovation, 2025, 22(15): 146-150.
    [83]
    CHAEMSAITHONG P, GIL M M, CHAIYASIT N, et al. Accuracy of placental growth factor alone or in combination with soluble fms-like tyrosine kinase-1 or maternal factors in detecting preeclampsia in asymptomatic women in the second and third trimesters: a systematic review and meta-analysis[J]. Am J Obstet Gynecol, 2023, 229(3): 222-247.
    [84]
    TIMÓN R, OLCINA G, CAMACHO-CARDEOSA M, et al. 48-hour recovery of biochemical parameters and physical performance after two modalities of CrossFit workouts[J]. Biology of Sport, 2019, 36(3): 283-289.
    [85]
    PENDYAL S, KOCH R L, JONES H N, et al. An assessment of dietary intake, feeding practices, growth, and swallowing function in young children with late-onset pompe disease: a framework for developing nutrition guidelines[J]. Nutrients, 2025, 17(11): 1909. DOI: 10.3390/nu17111909.
    [86]
    GOKER-ALPAN O, KASTURI V G, SOHI M K, et al. Pregnancy outcomes in late onset pompe disease[J]. Life (Basel), 2020, 10(9): 194. DOI: 10.3390/life10090194.
    [87]
    MORIN A G, SOMME D, CORVOL A. Rhabdomyolysis in older adults: outcomes and prognostic factors[J]. BMC Geriatr, 2024, 24(1): 46. DOI: 10.1186/s12877-023-04620-8.
    [88]
    KATSIKI N, MIKHAILIDIS D P, BAJRAKTARI G, et al. Statin therapy in athletes and patients performing regular intense exercise-Position paper from the International Lipid Expert Panel(ILEP)[J]. Pharmacol Res, 2020, 155: 104719. DOI: 10.1016/j.phrs.2020.104719.
    [89]
    PANDEY S N, MOGLAD E, GUPTA G, et al. Creatine kinase in prostate cancer: a biosensor-driven diagnostic paradigm[J]. Clin Chim Acta, 2025, 576: 120402. DOI: 10.1016/j.cca.2025.120402.
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