Volume 24 Issue 3
Mar.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(3): 382-385
ZHANG Xiujuan, ZHOU Wan, ZHANG Qunwei, ZHU Jie. Curative effect of quadruple therapy on hypertension complicated with cerebral infarction and its effect on serum PI3K/Akt signaling pathway[J]. Chinese Journal of General Practice, 2026, 24(3): 382-385. doi: 10.16766/j.cnki.issn.1674-4152.004401
Citation: ZHANG Xiujuan, ZHOU Wan, ZHANG Qunwei, ZHU Jie. Curative effect of quadruple therapy on hypertension complicated with cerebral infarction and its effect on serum PI3K/Akt signaling pathway[J]. Chinese Journal of General Practice, 2026, 24(3): 382-385. doi: 10.16766/j.cnki.issn.1674-4152.004401
shu

Curative effect of quadruple therapy on hypertension complicated with cerebral infarction and its effect on serum PI3K/Akt signaling pathway

doi: 10.16766/j.cnki.issn.1674-4152.004401
  • 1.

    Department of Pharmacy, the 901st Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army, Hefei, Anhui 230001, China

Funds:

 2023AH040398

  • Received Date: 2025-08-11
    Available Online: 2026-06-02
    Abstract
  •   Objective  To observe the clinical efficacy of quadruple therapy in the treatment of hypertension complicated with cerebral infarction, detect the expression changes of the serum phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway before and after treatment, and explore its potential mechanism of action.  Methods  A total of 158 patients with hypertension and cerebral infarction were selected from the 901st Hospital of the Joint Service Support Force of the Chinese People's Liberation Army from January 2021 to October 2024 as the study samples. The patients were divided into the control group and the observation group, with 79 patients each by random number table. The control group received triple therapy with aspirin enteric coated tablets, clopidogrel hydrogen sulfate tablets, and atorvastatin calcium tablets, while the observation group received quadruple therapy with amlodipine besylate tablets. The clinical efficacy of the two groups was compared, including systolic blood pressure (SBP), diastolic blood pressure (DBP), National Institutes of Health stroke scale (NIHSS) score, stroke specific quality of life scale (SS-QOL) score, serum PI3K and AKT protein expression levels, and incidence of adverse reactions after treatment.  Results  The total clinical effective rate of the observation group was 91.14% (72/79), which was significantly higher than that of the control group (70.89%, 56/79, χ2=15.003, P=0.001). After 1, 2, and 3 months of treatment, SBP, DBP, and NIHSS scores decreased in both groups, while SS-QOL scores increased, and serum levels of PI3K and AKT proteins decreased (P < 0.05), with more pronounced improvements observed in the observation group. Both time and group factors had significant effects on the outcomes (P < 0.05). The total incidence of adverse reactions in the observation group was 7.59% (6/79), while in the control group it was 13.92% (11/79), with no statistically significant difference (χ2=2.377, P=0.677).  Conclusion  Quadruple therapy is effective in the treatment of hypertension complicated with cerebral infarction. It can not only effectively control blood pressure, improve neurological function and quality of life, but also play a therapeutic role by regulating serum PI3K/Akt signaling pathway, without increasing the incidence of adverse reactions.

     

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