Volume 24 Issue 3
Mar.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(3): 472-475
BIAN Huanjie, QIAN Lyuli, ZHANG Linyan. Exploratory study on 3D-CPA for differential diagnosis and efficacy evaluation of AUB-O in perimenopause[J]. Chinese Journal of General Practice, 2026, 24(3): 472-475. doi: 10.16766/j.cnki.issn.1674-4152.004422
Citation: BIAN Huanjie, QIAN Lyuli, ZHANG Linyan. Exploratory study on 3D-CPA for differential diagnosis and efficacy evaluation of AUB-O in perimenopause[J]. Chinese Journal of General Practice, 2026, 24(3): 472-475. doi: 10.16766/j.cnki.issn.1674-4152.004422
shu

Exploratory study on 3D-CPA for differential diagnosis and efficacy evaluation of AUB-O in perimenopause

doi: 10.16766/j.cnki.issn.1674-4152.004422
  • 1.

    Department of Ultrasound, Zhuji Maternal and Child Health Hospital, Shaoxing, Zhejiang 311800, China

Funds:

 2023XY200

  • Received Date: 2025-02-06
    Available Online: 2026-06-02
    Abstract
  •   Objective  To explore the clinical value of three dimensional energy Doppler ultrasound (3D-CPA) in the diagnosis, evaluation, and efficacy monitoring of perimenopausal ovulation disorders associated with abnormal uterine bleeding (AUB-O).  Methods  A total of 160 patients with perimenopausal AUB and 160 healthy subjects admitted to Zhuji Maternal and Child Health Hospital were selected as the study subjects from September 2020 to March 2024. All study subjects underwent a uterine 3D-CPA examination to explore the differences in 3D-CPA parameters between perimenopausal AUB-O patients and other types of AUB patients, as well as healthy women.  Results  The 3D-CPA indicators of endometrial volume (EV), vascularity index (VI), flow index (FI), and vascular flow index (VFI) in perimenopausal AUB-O patients were higher than those in other types of AUB patients and healthy subjects (P < 0.001). Although the endometrial thickness of AUB-O patients and other types of AUB patients was higher than that of healthy subjects (P < 0.001), the difference between AUB-O patients and other types of AUB patients was not statistically significant (P>0.05). After 2 weeks of mifepristone treatment, the serum follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) levels in perimenopausal AUB-O patients significantly decreased compared to before treatment [(13.96±2.07) IU/L vs. (22.96±3.14) IU/L; (12.06±1.58) IU/L vs. (19.78±2.49) IU/L; (52.63±6.12) ng/L vs. (96.54±10.49) ng/L, P < 0.001]. The EV, VI, FI, and VFI values of AUB-O patients who were effectively treated with mifepristone were significantly lower than those of patients who were ineffective in treatment (P < 0.001). The changes in EV, VI, FI, and VFI before and after mifepristone treatment in perimenopausal AUB-O patients were positively correlated with changes in sex hormone levels (P < 0.05).  Conclusion  3D-CPA examination can effectively identify the differences in uterine blood flow supply and endometrial proliferation activity between AUB-O patients and healthy subjects, as well as between AUB-O patients with different therapeutic levels. Therefore, it has potential application value in AUB-O diagnosis, therapeutic evaluation, disease monitoring, and prognosis evaluation.

     

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