Volume 24 Issue 5
May  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(5): 735-738
LIU Chuang, DU Jianmin, QIN Ge, LUO Xiaohua, HAN Ning. A randomized controlled trial of dinoprostone vaginal suppository versus double-balloon catheter for labor induction in term pregnancies with hypertension[J]. Chinese Journal of General Practice, 2026, 24(5): 735-738. doi: 10.16766/j.cnki.issn.1674-4152.004479
Citation: LIU Chuang, DU Jianmin, QIN Ge, LUO Xiaohua, HAN Ning. A randomized controlled trial of dinoprostone vaginal suppository versus double-balloon catheter for labor induction in term pregnancies with hypertension[J]. Chinese Journal of General Practice, 2026, 24(5): 735-738. doi: 10.16766/j.cnki.issn.1674-4152.004479
shu

A randomized controlled trial of dinoprostone vaginal suppository versus double-balloon catheter for labor induction in term pregnancies with hypertension

doi: 10.16766/j.cnki.issn.1674-4152.004479

  • Department of Gynecology and Obstetrics, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China

Funds:

 SBGJ202302083

  • Received Date: 2025-08-27
    Available Online: 2026-10-23
    Abstract
  •   Objective  This study aimed to compare the safety and efficacy of dinoprostone vaginal suppositories and a double-balloon catheter for labor induction in women at term with hypertensive disorders of pregnancy, such as gestational hypertension and non-severe preeclampsia, to inform clinical decision-making.  Methods  This single-center, open-label, randomized controlled trial was conducted at the Third Affiliated Hospital of Zhengzhou University between August 2022 and June 2024. A total of 140 pregnant women diagnosed with gestational hypertension or non-severe preeclampsia at ≥ 37 weeks of gestation were enrolled and randomly assigned to the Dinoprostone group (n=70) or the catheter group (n=70) using a computer-generated randomization sequence.  Results  Successful labor induction was defined as vaginal delivery within 48 hours. The Dinoprostone group demonstrated a significantly higher rate of vaginal delivery within 24 hours compared to the double-balloon catheter group [37 (52.86%) vs. 16 (22.86%), P < 0.001], as well as a higher 48-hour delivery rate [54 (77.14%) vs. 31 (44.29%), P < 0.001]. Among nulliparous women, the dinoprostone group demonstrated significantly shorter time to labor onset [9.00 (3.59, 14.25) h vs. 17.67 (15.67, 19.50) h] and shorter time to vaginal delivery [21.85 (13.02, 31.92) h vs. 27.65 (24.99, 32.18) h] compared to controls (P < 0.05). While overall incidence of adverse events showed no significant differences between groups [16 (22.86%) vs. 11 (15.71%), P=0.284]. However, uterine hyperstimulation occurred more frequently in the dinoprostone group [6 (8.57%) vs. 0, P=0.028].  Conclusion  Dinoprostone vaginal suppositories are more effective than the double-balloon catheter for labor induction in term pregnancies complicated by hypertension, achieving higher delivery rates and shorter induction times with comparable safety. These findings support dinoprostone as a preferable option in this patient population.

     

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