Volume 24 Issue 5
May  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(5): 747-749
LI Yunnannan, WENG Jingjin, LI Xiang, XU Huan, HUANG Xiaoyan, LU Weisi, WU Suiyu, SHEN Yan. Epidemiologic characteristics and influencing factors of lung infection after radiotherapy for nasopharyngeal carcinoma[J]. Chinese Journal of General Practice, 2026, 24(5): 747-749. doi: 10.16766/j.cnki.issn.1674-4152.004482
Citation: LI Yunnannan, WENG Jingjin, LI Xiang, XU Huan, HUANG Xiaoyan, LU Weisi, WU Suiyu, SHEN Yan. Epidemiologic characteristics and influencing factors of lung infection after radiotherapy for nasopharyngeal carcinoma[J]. Chinese Journal of General Practice, 2026, 24(5): 747-749. doi: 10.16766/j.cnki.issn.1674-4152.004482
shu

Epidemiologic characteristics and influencing factors of lung infection after radiotherapy for nasopharyngeal carcinoma

doi: 10.16766/j.cnki.issn.1674-4152.004482
  • 1.

    Department of Otorhinolaryngology-Head and Neck Surgery, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530021, China

Funds:

 桂科AD20297069

 Z-A20220027

  • Received Date: 2025-06-17
    Available Online: 2026-10-23
    Abstract
  •   Objective  Patients with nasopharyngeal carcinoma (NPC) have a high incidence of pulmonary infection after chemoradiotherapy, which seriously affects their quality of life and prognosis. However, relevant literature reports on this issue are scarce. Therefore, this study aims to analyze the epidemiological characteristics and risk factors of pulmonary infection in NPC patients following chemoradiotherapy, so as to provide a reference for early assessment, prevention, and targeted nursing interventions.  Methods  A retrospective analysis was performed on the clinical data of 1 033 nasopharyngeal carcinoma patients who met the indications for chemoradiotherapy and were admitted to the People's Hospital of Guangxi Zhuang Autonomous Region from January 2019 to December 2023. The patients were divided into group A (299 cases) with pulmonary infection and group B (734 cases) without pulmonary infection. Univariate analysis and multivariate logistic regression analysis were conducted to explore the influencing factors of pulmonary infection in nasopharyngeal carcinoma patients after chemoradiotherapy.  Results  The incidence of pulmonary infection was 28.94% among 1 033 enrolled patients. Logistic regression analysis revealed that age (OR=1.028), smoking history (OR=2.526), body mass index (BMI, OR=0.906), tumor recurrence status (OR=0.085), targeted therapy (OR=0.540) and plasma Epstein-Barr virus DNA load (OR=19.616) were influencing factors for pulmonary infection.  Conclusions  The incidence of pulmonary infection is relatively high in nasopharyngeal carcinoma patients after radiotherapy and chemotherapy. Advanced age, smoking history, low BMI, non-recurrent tumor, absence of targeted therapy and elevated plasma Epstein-Barr virus DNA level are associated with increased risk of pulmonary infection. It is recommended that early assessment targeting these risk factors be conducted for these patients. For high-risk ones, increased monitoring frequency and enhanced respiratory care should be implemented to reduce the risk of concurrent pulmonary infection.

     

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