Volume 24 Issue 5
May  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(5): 769-772
QIU Chu, CHEN Caifei, CHEN Xiao, ZHU Xiaoyan, CAI Luwei. Correlation between abnormalities in the Wnt/β-catenin signaling pathway and the therapeutic effect of Qushi Jianfa Decoction in seborrheic alopecia[J]. Chinese Journal of General Practice, 2026, 24(5): 769-772. doi: 10.16766/j.cnki.issn.1674-4152.004487
Citation: QIU Chu, CHEN Caifei, CHEN Xiao, ZHU Xiaoyan, CAI Luwei. Correlation between abnormalities in the Wnt/β-catenin signaling pathway and the therapeutic effect of Qushi Jianfa Decoction in seborrheic alopecia[J]. Chinese Journal of General Practice, 2026, 24(5): 769-772. doi: 10.16766/j.cnki.issn.1674-4152.004487
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Correlation between abnormalities in the Wnt/β-catenin signaling pathway and the therapeutic effect of Qushi Jianfa Decoction in seborrheic alopecia

doi: 10.16766/j.cnki.issn.1674-4152.004487

  • Department of Dermatology, Shaoxing Hospital of Traditional Chinese Medicine, Shaoxing, Zhejiang 312000, China

Funds:

 2025ZL579

  • Received Date: 2025-12-24
    Available Online: 2026-10-23
    Abstract
  •   Objective  To investigate the abnormal expression of key molecules (Wnt3a, β-catenin, DKK1) in the Wnt/β-catenin signaling pathway in patients with seborrheic alopecia and to evaluate their correlation with the therapeutic efficacy of Qushi Jianfa Decoction, as well as their predictive value.  Methods  A total of 120 patients with seborrheic alopecia admitted to Shaoxing Hospital of Traditional Chinese Medicine between August 2024 and August 2025 were selected and randomly assigned using a random number table into the study group (n=60) and the positive control group (n=60), 100 healthy individuals undergoing physical examinations were selected as the control group. Serum levels of Wnt3a, β-catenin, and DKK1 were measured in all three groups. Patients were further stratified into an effective subgroup (n=49) and an ineffective subgroup (n=11) based on treatment efficacy. Statistical analyses included two-column correlation analysis, multivariate logistic regression, and ROC curve analysis.  Results  The treatment group and the positive control group exhibited lower levels of Wnt3a [(35.62±8.94) pg/mL, (36.29±9.12) pg/mL] and β-catenin [(2.15±0.68) ng/mL, (2.31± 0.81) ng/mL] compared to the control group [(58.73±10.25) pg/mL, (3.82±0.95) ng/mL], while DKK1 [(189.35±32.67) pg/mL, (187.71±33.16) pg/mL] was higher than in the control group [(102.46±25.38) pg/mL, F=153.378, 96.853, 228.845, all P < 0.001]. In the treatment group, Wnt3a and β-catenin levels increased, while DKK1 decreased after therapy (P < 0.05). Wnt3a and β-catenin showed positive correlations with therapeutic efficacy, whereas DKK1 exhibited a negative correlation (P < 0.001). A disease course of ≥3 years, severe alopecia, elevated pre-treatment DKK1 level, decreased pretreatment Wnt3a level, and decreased pre-treatment β-catenin level are independent risk factors for the efficacy of Qushi Jianfa Decoction (P < 0.05); whereas elevated pre-treatment Wnt3a level and elevated pre-treatment β-catenin level are independent protective factors for the efficacy of Qushi Jianfa Decoction (P < 0.05). The combined detection of Wnt3a, β-catenin, and DKK1 demonstrated optimal predictive performance (AUC=0.850).  Conclusion  Seborrheic alopecia exhibits abnormalities in the Wnt/β-catenin pathway, with its key molecules closely associated with disease severity and the therapeutic efficacy of Qushi Jianfa Decoction.

     

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