Volume 24 Issue 5
May  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(5): 782-785
ZHAO Guoqing, LU Huijuan, MO Huijuan. The symptom burden trajectory of patients in the early stage of peritoneal dialysis and its impact on recent cardiovascular and cerebrovascular events[J]. Chinese Journal of General Practice, 2026, 24(5): 782-785. doi: 10.16766/j.cnki.issn.1674-4152.004490
Citation: ZHAO Guoqing, LU Huijuan, MO Huijuan. The symptom burden trajectory of patients in the early stage of peritoneal dialysis and its impact on recent cardiovascular and cerebrovascular events[J]. Chinese Journal of General Practice, 2026, 24(5): 782-785. doi: 10.16766/j.cnki.issn.1674-4152.004490
shu

The symptom burden trajectory of patients in the early stage of peritoneal dialysis and its impact on recent cardiovascular and cerebrovascular events

doi: 10.16766/j.cnki.issn.1674-4152.004490

  • Department of Nephrology, the First People's Hospital of Linping District, Hangzhou (Hangzhou Second Hospital Linping Branch), Hangzhou, Zhejiang 311110, China

Funds:

 B20231482

 B20252729

 2025ZX139

  • Received Date: 2025-08-29
    Available Online: 2026-10-23
    Abstract
  •   Objective  During the initial period of peritoneal dialysis, patients experience complex and fluctuating symptoms. However, the dynamic patterns of these changes remain unclear. This study aims to identify potential trajectories of symptom burden in patients undergoing the initial phase of peritoneal dialysis and to explore the association between different trajectory characteristics and the risk of short-term cardiovascular and cerebrovascular adverse events (CCE), thereby providing evidence for early individualized intervention and improved long-term prognosis.  Methods  Patients in the early stage of peritoneal dialysis in the First People's Hospital of Linping District, Hangzhou from October 2022 to April 2025 were selected as the survey subjects. The recent incidence of CCE was statistically analyzed after two years of dialysis. The dialysis frequency severity and symptom burden index (DFSSBI) was used to assess the symptom burden at the initial dialysis (T0), 1 month of dialysis (T1), 3 months of dialysis (T2), and 6 months of dialysis (T3). The symptom burden trajectory was classified through the latent variable growth mixed model (LGMM). Logistic regression was used to analyze the influence of symptom burden trajectory on recent CCE.  Results  Among the 164 patients in the early stage of peritoneal dialysis included, 150 patients eventually completed the investigation. The follow-up period ranged from 3 to 32 months, with a median follow-up period of 15 months. CCE occurred in 40 patients, with an incidence rate of 26.67% (40/150). It was identified that there were three symptom burden trajectories for patients in the early stage of peritoneal dialysis: the low-level stable group (C1 group), the medium-level remission group (C2 group), and the high-level fluctuation group (C3 group). The symptom burden trajectory showed a significant linear trend with the occurrence of recent CCE, and the incidence of recent CCE was the highest in group C3 (P < 0.05).  Conclusion  There is population heterogeneity in the symptom burden trajectory of patients in the early stage of peritoneal dialysis. A persistently high symptom burden will increase the risk of recent CCE events in patients.

     

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