Effects of early high-dose ulinastatin combined mucosolvan on respiratory function and levels of inflammatory cytokines in patients with severe burns

Objective To explore the effects of early high-dose ulinastatin combined Mucosolvan on respiratory function and levels of inflammatory cytokines in patients with severe burns. Methods One hundred severe burn patients were randomly divided into observation group and control group.All the patients were given conventional regimen burns,at the same period,the observation group was treated with early high-dose ulinastatin 400 000 U combined Mucosolvan 450 mg,the control group was given regular doses of early Ulinastatin 100 000 U combined Mucosolvan 30 mg.The respiratory function parameters and inflammatory cytokines were observed. Results ①After the treatment,one-way repeated-measures ANOVA showed that the respiratory rate,PaO₂,PaO₂/FiO₂ at each time point was statistically significant(P＜0.05);the respiratory rate of the observation group decreased significantly when compared with the control group 7 d and 12 d after the treatment,while PaO₂ and PaO₂/FiO₂ increased significantly as compared with the control group 3 d,7 d and 12 d after the treatment,the difference was statistically significant(P＜0.05);②After the treatment,one-way repeated-measures ANOVA showed that serum TNF-α,IL-1,IL-6 and IL-8 levels at each time point statistically significant(P＜0.05),serum TNF-α,IL-1,IL-6 and IL-8 levels increased at d2 and d7,but decreased at d12 after the treatment;the increased serum TNF-α,IL-1,IL-6,IL-8 levels were not obviously as compared with the control group,while the levels at d12 declined significantly when compared with the control group,the difference was statistically significant(P＜0.05). Conclusion Early high-dose ulinastatin combined Mucosolvan for the patients with severe burns can protect their respiratory function,reduce the levels of inflammatory cytokines with a significant clinical effect.