Analysis of effect of racemic hyoscyamine eye drops applied in juvenile myopia

Objective To observe the effect of racemic hyoscyamine eye drops applied in juvenile myopia. Methods One hundred and sixty-six cases of adolescent patients with 332 myopia eyes treated in department of ophthalmology of Lishui central hospital from December 2012 to March 2014 were selected and divided into group A and groupB,randomly.0.05% racemic hyoscyamine was given in group A other than wearing glasses,and only wearing glassesgiven in group B.Visual acuity and adverse reaction were compared in 1 year. Results The mean vision in group A was 5.01±0.03，while 4.82±0.09 in group B.It was higher in group A than that in group B(t=10.504，P<0.05).The change of diopter in group A was(0.07±0.02)D,while (0.49±0.11)D in group B.It was lower in group A than that in group B(t=18.051，P<0.05).The change of axial in group A was (0.09±0.04) mm,while (0.14±0.04) mm in group B,it was lower in group A than that in group B(t=3.647，P<0.05).The intraocular pressure in group A was(15.01±2.30) mm Hg,while (14.97±2.11) mm Hg in group B.There was no statistical differences between the two groups(t=1.181，P>0.05).There were 77 cases of vision improvement,117 cases of visual disability,and 138 cases of vision decreasing in group A,and the vision decreasing rate was 41.57%，There were 24 cases of vision improvement,57 cases of visual disability,and 251 cases of vision decreasing in group A,and the vision decreasing rate was 75.60%.The decreasing rate in group A was lower than that in group B(χ²=19.015，P<0.05).There was no symptoms such as photophobia,blurred vision,eye pain,eye itching etc.and there was no obvious exception under slit lamp examination. Conclusion It was effective applying 0.05% racemic hyoscyamine treating juvenile myopia,and safe.It was worthy of clinical application.