Relationship between serum indoxyl sulfate level and indices associated with cardiovascular disease in patients with chronic kidney disease

Objective To explore the relationship between serum indoxyl sulfate(IS) levels indices associated with cardiovascular disease(CVD) in patients with chronic kidney disease(CKD),and to provide clinical reference for the prevention of cardiovascular events in CKD patients. Methods Total 112 cases of CKD was recruited and divided into stage 3 group,stage 4 group and stage 5 group,and 40 normal subjects were assigned into the control group.The general clinical data were recorded.The serum IS level was detected by high performance liquid chromatography.CVD indices such as LVDd,IVST,LVPTW,EF,A,E and A/E were measured by Color Doppler echocardiography.The relation between IS and CVD indices were analyzed statistically. Results The biochemical indices and the serum level of IS of all patients in CKD groups were obviously higher than that of the control group.The serum level of IS was (0.08±0.06) μg/ml in the control group,and (0.13±0.12) μg/ml,(0.48±0.53) μg/ml and (2.74±2.49) μg/ml(P<0.05) in CKD 3/4/5 groups,respectively;serum IS was increased with the decreased renal function(P<0.05);the abnormal cardiac structure and function were shown in CKD patients,while interventricular septum and the ventricular wall were thicken and ventricular diameter were increased,the A/E>1,the ejection fraction were declined,significantly positive correlation were detected among serum IS and CVD indexes (systolic pressure,diastolic blood pressure,TC,TG,LDL-C,P,iPTH,IVST,LVPWT). Conclusion IS can be accumulated in serum along with the decline of renal function in CKD patients;patients with CKD and CVD always has myocardial hypertrophy and ventricular systolic and diastolic dysfunction;IS may play an important role in the development of CVD in CKD patients.