Immunoglobulin as adjuvant therapy for septicemia in premature infants

Objective To investigate the mechanism and effect of immunoglobulin as adjuvant therapy for septicemia in premature infants. Methods Total 118 premature infants with septicemia were randomly divided into observation group(n=58) and control group(n=60). Both groups were given conventional anti infection treatment. The observation group was given immunoglobulin on the first day of diagnosis of septicemia,400 mg/kg per day for 3 days. The recovery time of clinical and laboratory index and the mortality rate were compared between the two groups. The serum Ig G level was compared before and after the treatment. Results The clinical recovery in the observation group was quickly as compared with the control group[(6. 93 ±1. 43) d vs.(8. 47 ±2. 13) d,P < 0. 05]. The recovery time of WBC,PLT,RP and PCT of the observation group were all earlier than those of the control group(P < 0. 05). The mortality rate of the observation group was lower than that of the control group(5. 2% vs. 16. 7%,P < 0. 05). In the observation group,the serum Ig G level increased significantly after the treatment(P < 0. 01); in the control group,the Ig G level was not improved after the treatment(P > 0. 05). Conclusion Immunoglobulin can increase the serum Ig G level and enhance the humoral immune function of the premature infants,it is effective as adjuvant therapy for septicemia in premature infants.