Association of estrogen receptor 1 gene polymorphism with idiopathic scoliosis in adolescents:a Meta-analysis

Objective To assess the potential associations of estrogen receptor 1 gene (ESR1) rs9340799(Xbal locus) and rs223469(PvuⅡ locus) polymorphism with adolescent idiopathic scoliosis(AIS). Methods Studies on AIS published up to July 23,2015 were initially searched from PubMed,Wangfang Med Online,China Biological Medicine Database(CBM),China National Knowledge Infrastructure(CNKI) and VIP Database,and then eligible case-control data on associations of ESR1 with AIS were retrieved by the inclusion criteria.Meta-analysis was performed using Stata software(version 12.0),and odds ratio(OR) value for the data was pooled for evaluation of the publication bias. Results By the pre-determined inclusion and exclusion criteria,a total of 4 articles were finally included in this meta-analysis.Associations of ESR1 rs9340799 predisposition with AIS appeared in 4 articles,and rs2234693 in 3.The studies indicated that the OR value for correlation of ESR1 rs9340799 gene polymorphism with AIS was 1.08(0.83-1.21),1.06(0.91-1.24) and 1.08(0.63-1.83) for allele model(G vs. A),dominant model (GG+AG vs. AA),and recessive model(GG vs. AG+AA),respectively.The difference was not significant.By association of ESR1 rs2234693 gene polymorphism with AIS,the OR value was 1.08(0.92-1.26),1.07(0.85-1.35) and 1.14(0.85-1.54),respectively for allele model(C vs. T),dominant model(CC+TC vs. TT) and recessive model(CC vs. TC+TT),with no statistical significance. Conclusion Our meta-analysis suggests that current studies can not supply enough evidences to prove the associations of ESR1 rs9340799 and rs2234693 gene polymorphisms with AIS.