Levels of Vaspin and ATGL and their gene expressions in patients with different types of coronary artery disease

Objective To learn the levels of Vaspin and ATGL and their gene expressions in patients with different types of coronary artery disease and their gene expression. Methods One hundred and fifty-seven patients with different types of coronary heart disease were divided into 62 cases of SAP group,54 cases of UAP group and 41 cases of AMI group,and 55 cases of healthy persons were selected as control group.Blood lipid levels,serum Vaspin,ATGL and gene expression levels were detected,and Gensini score was used to evaluate the degree of coronary artery disease. Results TG,LDL-C,LP (a) levels of SAP,UAP,AMI groups were higher than control group,HDL-C,Vaspin,ATGL,Vaspin,ATGL gene relative expressions were lower than control group (P<0.05);TG,LDL-C,LP (a) level,Gensini score of AMI group were higher than SAP and UAP groups,HDL-C,Vaspin,ATGL,Vaspin,ATGL gene relative expressions were lower than SAP and UAP groups (P<0.05);TG,LDL-C,LP (a) level,Gensini score of UAP group were higher than SAP group,HDL-C,Vaspin,ATGL,Vaspin,ATGL gene relative expressions were lower than SAP group (P<0.05).Vaspin level of patients with coronary heart disease was positively correlated with ATGL and HDL-C (P<0.05),and was negatively correlated with TG,LDL-C,LP (a) and Gensini score (P<0.05);ATGL level was positively correlated with HDL-C (P<0.05),and was negatively correlated with TG,LDL-C,LP (a) and Gensini score (P<0.05). Conclusion ATGL,Vaspin and coronary artery disease are related;detection of Vaspin,ATGL levels and gene expressions can provide a new way for the diagnosis and treatment of coronary artery disease.