Effects of Sevoflurane and Propofol combined with Remifentanil on hemodynamics in elderly patients with esophageal cancer after radical operation

Objective To investigate the effects of Sevoflurane and Propofol combined with Remifentanil on hemodynamics in elderly patients with esophageal cancer after radical operation. Methods A total of 72 cases of esophageal cancer patients in our hospital were divided into two groups with 36 cases in each group.All patients were induced by Remifentanil (3 ng/ml),Propofol (3 μg/ml) and cis-ammonium bromide for anesthesia induction.The patients in the observation group were given seven Sevoflurane combined with target controlled infusion of Remifentanil for anesthesia maintenance,while the patients in control group were given target controlled infusion of Propofol combined with Remifentanil for anesthesia maintenance.Before anesthesia (T1),skin incision (T2) and the end of operation (T3),extubation (T4),the hemodynamics index of two groups of patients were compared,including systolic blood pressure (SBP),diastolic blood pressure (DBP),mean arterial pressure (MAP),heart rate (HR),the depth of anesthesia (BIS value).The pain of patients after extubation was assessed by visual analogue scale (VAS).The awaking time and time to extubation of patients in two groups were recorded.The incidence of adverse reactions of both groups was recorded,including nausea and vomiting,restlessness and shivering and respiratory depression. Results At T2 and T3,SBP,DBP,MAP,HR,BIS values of patients in both groups were significantly lower than in the level of T1,the difference was statistically significant (P<0.05).At each time point,SBP,DBP,MAP,HR,BIS value between the two groups were compared,the difference was not statistically significant (P>0.05).The VAS score,awaking time and time to extubation of the observation group were significantly lower than those of the control group,the difference was statistically significant (P<0.05).Adverse reaction rates (11.11% vs.13.89%) were compared between the two groups,and the difference was not statistically significant (P>0.05). Conclusion Sevoflurane and Propofol combined with Remifentanil anesthesia in elderly patients with esophageal cancer is similar.The recovery time is shorter in procedure with Sevoflurane combined with Remifentanil.