Effects of local infiltration anesthesia with epinephrine and lidocaine on hemodynamics parameters in patients undergoing endoscopic sinus surgery

Objective To explore the effects of local infiltration anesthesia with epinephrine and lidocaine on hemodynamics parameters in patients undergoing endoscopic sinus surgery;and to provide clinical data for the rational use of epinephrine. Methods Total 173 patients undergoing endoscopic sinus surgery were randomly divided into group A (n=55),group B (n=66) and group C (n=52,control group).Local infiltration anesthesia method:group A was given lidocaine combined with 20 μg epinephrine;group B was given lidocaine and 40 μg epinephrine;group C was given lidocaine.The heart rate (HR),mean arterial pressure (MAP),cardiac index (CI),and acceleration index (ACI) in all three groups were measured before anesthesia and 1,1.5,2,3,4,6 min after infiltration anesthesia,respectively. Results At 1.5 and 2 min after infiltration anesthesia,HR increased in group A and group B,and MAP decreased (P<0.05);At 3 min after infiltration anesthesia,HR increased in group B (P<0.05);Compared with group A,HR and MAP decreased significantly in group B at 1.5 and 2 min after infiltration anesthesia (P<0.05).The CI and ACI of group A and group B were increased at 1.5,2,3 and 4 min after infiltration anesthesia (P<0.05);Compared with group A,the CI and ACI of group B increased significantly at 1.5,2,3 and 6 min after infiltration anesthesia,respectively (P<0.05). Conclusion Local infiltration anesthesia with epinephrine combined lidocaine has effect on hemodynamics in patients undergoing endoscopic sinus surgery;the degree of influence is related to the dose of epinephrine,and 20 μg epinephrine is recommended.