Volume 20 Issue 5
May  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(5): 731-734
FAN Jing, HUANG Guan-wen, BAO Ji-wen, ZHANG Min-fang, ZHOU Wen-yan, WANG Qin, NI Zhao-hui, WANG Ling. Analysis of risk factors for the prognosis of IgA nephropathy[J]. Chinese Journal of General Practice, 2022, 20(5): 731-734. doi: 10.16766/j.cnki.issn.1674-4152.002441
Citation: FAN Jing, HUANG Guan-wen, BAO Ji-wen, ZHANG Min-fang, ZHOU Wen-yan, WANG Qin, NI Zhao-hui, WANG Ling. Analysis of risk factors for the prognosis of IgA nephropathy[J]. Chinese Journal of General Practice, 2022, 20(5): 731-734. doi: 10.16766/j.cnki.issn.1674-4152.002441
shu

Analysis of risk factors for the prognosis of IgA nephropathy

doi: 10.16766/j.cnki.issn.1674-4152.002441
  • 1.

    Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

Funds:

 19ZR1430800

 16CR3022A

  • Received Date: 2021-05-25
    Available Online: 2022-09-05
    Abstract
  •   Objective  To explore the risk factors affecting the prognosis of patients with IgA nephropathy by analyzing the clinical and pathological data of patients with IgA nephropathy, so as to provide clinical reference, and pay attention to early diagnosis and long-term follow-up.  Methods  The clinical and pathological data of patients with IgA nephropathy who underwent renal biopsy in Renji Hospital from December 2012 to December 2015 were analyzed. Serum creatinine (SCr) and 24-hour urinary protein were recorded every 3 months. The end points were set as SCr increased over 50% or reached end stage renal disease (ESRD) while following up. Kaplan Meier survival analysis was used to analyze the renal survival rate of patients with IgA nephropathy. Cox regression was used to analyze the prognostic risk factors of IgA nephropathy.  Results  Total 163 IgA nephropathy patients who had long term follow up (median follow up period 29 months) were included. The median age was 33 years old, 82(50.3%) were male, 7 patients (4.3%) reached the end points and 4-year kidney survival rate was 86.8%. The results of multivariate analysis of Cox proportional risk model showed that baseline systolic blood pressure (HR= 1.073, 95% CI: 1.018 - 1.132, P=0.009) and time averaged urinary protein excretion (TA-UPE, HR=2.123, 95% CI: 1.367-3.329, P=0.001) were the independent risk factors for prognosis of IgA nephropathy.  Conclusion  Various factors are correlated to the prognosis of IgA nephropathy whereas baseline systolic blood pressure and TA-UPE are the independent risk factors.

     

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