Volume 20 Issue 5
May  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(5): 789-792
LI Xiu-yi, QI Xiang-ming, XIA Yuan-yuan, LUO Rui, HAN Shu-wei, YU Xiao-qin. Clinical value of serum human epididymal protein 4 in the diagnosis of chronic kidney disease[J]. Chinese Journal of General Practice, 2022, 20(5): 789-792. doi: 10.16766/j.cnki.issn.1674-4152.002455
Citation: LI Xiu-yi, QI Xiang-ming, XIA Yuan-yuan, LUO Rui, HAN Shu-wei, YU Xiao-qin. Clinical value of serum human epididymal protein 4 in the diagnosis of chronic kidney disease[J]. Chinese Journal of General Practice, 2022, 20(5): 789-792. doi: 10.16766/j.cnki.issn.1674-4152.002455
shu

Clinical value of serum human epididymal protein 4 in the diagnosis of chronic kidney disease

doi: 10.16766/j.cnki.issn.1674-4152.002455
  • 1.

    Department of Clinical Laboratory, the First People's Hospital of Hefei (the Third Affiliated Hospital of Anhui Medical University), Hefei, Anhui 230061, China

Funds:

 1908085MH245

  • Received Date: 2021-11-11
    Available Online: 2022-09-05
    Abstract
  •   Objective  To investigate the clinical diagnostic value of serum human epididymal protein 4 (HE4) in chronic kidney disease (CKD) and different stages.  Methods  A total of 117 patients with CKD admitted to the Department of Nephrology of Hefei First People's Hospital from February 2019 to September 2020 were selected as the observation group, and 78 healthy patients with the same age during the same period were selected as the control group. The expression levels of serum HE4, urea nitrogen (BUN), creatinine (SCr), cystatin C (CysC) and retinol-binding protein (RBP) in the subjects of the two groups were detected to observe the correlation and clinical diagnostic value of CKD.  Results  The expression levels of serum HE4, BUN, SCr, CysC and RBP in the CKD group were significantly higher than those in the control group (all P < 0.01). As the CKD stage of the patients increased, no significant difference in the early grouping of BUN, SCr and RBP was found compared with the control group in each stage of CKD and the control group (all P>0.05). The other staging groups were compared with the control group, and the differences were statistically significant (all P < 0.01). The comparison amongst the CKD 1 - 5 staging groups revealed that the HE4, CysC and RBP groups had statistically significant differences (all P < 0.05), and BUN and SCr were significantly different (all P < 0.05). Compared between groups, there was no significant difference between CKD 1 and CKD 2 (all P>0.05), and significant differences were noted between the CKD 3 and CKD 5 groups and compared with CKD 1 to CKD 2 (all P < 0.01). The expression level of serum HE4 was negatively correlated with eGFR but positively correlated with BUN, SCr, CysC and RBP. ROC analysis showed that the area under the curve of HE4 (AUC=0.978) was significantly better than that of Bun (AUC=0.956), SCr (AUC=0.973), CysC (AUC=0.992) and RBP (AUC=0.910).  Conclusion  The serum HE4 level is related to the occurrence and development of CKD, and it has certain clinical significance for the staging of CKD. Serum HE4 is expected to function as a new serum biological diagnostic marker for the progression and prognosis of CKD.

     

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