Volume 21 Issue 7
Jul.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(7): 1093-1096
SU Yan, LIU Kai, DU Yuanyuan, XIONG Bochao, LIANG Lei, LUO Song, QU Hongdang. Study on the correlation between miR-184 expression levels and disease severity, inflammatory factors in patients with acute cerebral infarction[J]. Chinese Journal of General Practice, 2023, 21(7): 1093-1096. doi: 10.16766/j.cnki.issn.1674-4152.003057
Citation: SU Yan, LIU Kai, DU Yuanyuan, XIONG Bochao, LIANG Lei, LUO Song, QU Hongdang. Study on the correlation between miR-184 expression levels and disease severity, inflammatory factors in patients with acute cerebral infarction[J]. Chinese Journal of General Practice, 2023, 21(7): 1093-1096. doi: 10.16766/j.cnki.issn.1674-4152.003057
shu

Study on the correlation between miR-184 expression levels and disease severity, inflammatory factors in patients with acute cerebral infarction

doi: 10.16766/j.cnki.issn.1674-4152.003057

  • Department of Neurology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0364

  • Received Date: 2023-02-18
    Available Online: 2023-08-28
    Abstract
  •   Objective  To investigate the correlation between serum miR-184 levels and severity of disease and with inflammatory factors in patients with acute cerebral infarction (ACI).  Methods  A total of 74 ACI patients and 41 healthy individuals were included in the Neurology Department of the First Affiliated Hospital of Bengbu Medical College from January to December 2021. The expression levels of miR-184, IL-6, TNF-α and CRP in the serum of the two groups were detected using qPCR and ELISA methods; the levels between two groups were compared, and Pearson correlation analysis was applied to study the correlation between miR-184 levels and inflammatory factors in ACI patients.  Results  Compared with the control group, the levels of miR-184 in the ACI group decreased (P < 0.001), while the levels of IL-6, TNF-α, and CRP increased (all P < 0.05). The larger the infarct size, the higher the NHISS score, and the lower the miR-184 level. Spearman correlation analysis showed that the level of serum miR-184 in ACI patients was negatively correlated with disease severity and infarct volume (rs=-0.641, -0.620, both P < 0.05). The level of serum miR-184 in ACI patients was also correlated with the levels of inflammatory factors IL-6, TNF-α and CRP levels (rs=-0.560, -0.389, -0.565, all P < 0.05).  Conclusion  miR-184 can be used as a serological marker for diagnosing ACI and evaluating the severity of the condition, and is a promising target for the treatment of ACI.

     

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