Volume 21 Issue 7
Jul.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(7): 1113-1116
YANG Yiling, LI Yuee, ZHANG Junfeng, ZHANG Yun. Study on the changes of cortical excitability in patients with postherpetic neuralgia evaluated by transcranial magnetic stimulation[J]. Chinese Journal of General Practice, 2023, 21(7): 1113-1116. doi: 10.16766/j.cnki.issn.1674-4152.003062
Citation: YANG Yiling, LI Yuee, ZHANG Junfeng, ZHANG Yun. Study on the changes of cortical excitability in patients with postherpetic neuralgia evaluated by transcranial magnetic stimulation[J]. Chinese Journal of General Practice, 2023, 21(7): 1113-1116. doi: 10.16766/j.cnki.issn.1674-4152.003062
shu

Study on the changes of cortical excitability in patients with postherpetic neuralgia evaluated by transcranial magnetic stimulation

doi: 10.16766/j.cnki.issn.1674-4152.003062
  • 1.

    Outpatient Department, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510000, China

Funds:

 20231213

 广药大护2022-8

  • Received Date: 2023-03-20
    Available Online: 2023-08-28
    Abstract
  •   Objective  To explore differences of cortical excitability assessed by transcranial magnetic stimulation (TMS) between patients with postherpetic neuralgia (PHN) and healthy controls, and to examine their relationships with pain symptoms severity.  Methods  A total of 30 PHN patients and 30 age-and sex-matched healthy controls underwent single- and paired-pulse TMS applied to the left and right motor cortex in Outpatient Department of the First Affiliated Guangdong Pharmaceutical University from August 2022 to March 2023. The test indexes included resting motor threshold (RMT), mean wave amplitude of motor evoked potentials (MEPs) at the optimal stimulation point, and cortical resting period (SP). Three different stimulation intensities (CS=70%/80%/90% AMT) with an interval of 2 ms were used to observe the intracortical inhibition (SICI) and the stimulation interval of 12 ms intracortical ease (SICF) index. The extent of PHN disease was assessed using the disease course, visual analog scoring scale (VAS).  Results  Compared with healthy controls (55.25±5.05), patients with PHN demonstrated significantly increased RMT values (60.91±5.52) in contralateral hemisphere (P < 0.05), while average MEPs, SP and SICF showed no significant differences between PHN patients and healthy controls (P>0.05). SICI measurements in the motor cortex of the affected dominant area were higher in the PHN group (0.81±0.09) than that in the healthy control group (0.73±0.08, P < 0.05) under the stimulation intensity of 70% AMT. Correlation analysis revealed a positive correlation between SICI measurements in the affected dominant cortical area and disease duration in the PHN group (r=0.323, P < 0.05).  Conclusion  Patients with PHN have diminished motor cortical excitability in the affected dominant area and impaired cortical inhibition in the affected dominant area, and the degree of impairment correlates with the duration of the disease.

     

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