Volume 21 Issue 7
Jul.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(7): 1134-1137
WANG Yafei, WANG Liqun, YE Guoliu. Clinical features, treatment and prognosis of vaginal intraepithelial neoplasia[J]. Chinese Journal of General Practice, 2023, 21(7): 1134-1137. doi: 10.16766/j.cnki.issn.1674-4152.003067
Citation: WANG Yafei, WANG Liqun, YE Guoliu. Clinical features, treatment and prognosis of vaginal intraepithelial neoplasia[J]. Chinese Journal of General Practice, 2023, 21(7): 1134-1137. doi: 10.16766/j.cnki.issn.1674-4152.003067
shu

Clinical features, treatment and prognosis of vaginal intraepithelial neoplasia

doi: 10.16766/j.cnki.issn.1674-4152.003067

  • Department of Obstetrics and Gynecology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0343

 BYKY2019119ZD

  • Received Date: 2022-09-12
    Available Online: 2023-08-28
    Abstract
  •   Objective  To study the general clinical characteristics, treatment and prognosis of vaginal intraepithelial neoplasia (VAIN).  Methods  The clinical data of 168 patients with histologically confirmed VAIN admitted to the First Affiliated Hospital of Bengbu Medical College from January 2019 to February 2022 were retrospectively collected. The sensitivity of different screening methods to the diagnosis of VAIN and the regression of lesions after treatment were compared.  Results  The average age of the patients was (49.52±11.63) years old, of which 115 cases (68.5%) were 45 years old and above, and 57.1% of the patients were postmenopausal. The screening sensitivity of cytology, HPV, colposcopy, and cytology combined with HPV were 61.5%, 92.4%, 84.6% and 95.0%, respectively. The overall sensitivity of HPV screening was significantly higher than that of cytology (P=0.001). There was no significant difference in the sensitivity of cytological screening between patients after hysterectomy and those without hysterectomy (P=0.718). The pathological coincidence rate of colposcopy was higher than that of cytology (P=0.001). There was a positive correlation between the grade of VAIN and the grade of cervical lesions (r=0.162, P=0.036). HPV16 was the most common genotype of VAIN. Among the 97 patients who were followed up after treatment, 83 patients (85.6%) had lesion degradation and regression, of which 2 patients relapsed again after regression and improved after re-treatment. Five patients (5.2%) had lesion progression, of which 1 patient with VAIN3 progressed to vaginal cancer. The prognosis of VAIN patients may be related to age.  Conclusion  Cytology, HPV and colposcopy can still be used as a diagnostic procedure for VAIN. After active treatment and follow-up, most patients have a good prognosis.

     

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