Clinical features, treatment and prognosis of vaginal intraepithelial neoplasia

WANG Yafei; WANG Liqun; YE Guoliu

doi:10.16766/j.cnki.issn.1674-4152.003067

Volume 21 Issue 7

Jul. 2023

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Article Navigation > Chinese Journal of General Practice > 2023 > 21(7): 1134-1137

WANG Yafei, WANG Liqun, YE Guoliu. Clinical features, treatment and prognosis of vaginal intraepithelial neoplasia[J]. Chinese Journal of General Practice, 2023, 21(7): 1134-1137. doi: 10.16766/j.cnki.issn.1674-4152.003067

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WANG Yafei, WANG Liqun, YE Guoliu. Clinical features, treatment and prognosis of vaginal intraepithelial neoplasia[J]. Chinese Journal of General Practice, 2023, 21(7): 1134-1137. doi: 10.16766/j.cnki.issn.1674-4152.003067

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Clinical features, treatment and prognosis of vaginal intraepithelial neoplasia

doi: 10.16766/j.cnki.issn.1674-4152.003067

Department of Obstetrics and Gynecology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

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KJ2019A0343

BYKY2019119ZD

Received Date: 2022-09-12
Available Online: 2023-08-28

Abstract

Abstract

Objective To study the general clinical characteristics, treatment and prognosis of vaginal intraepithelial neoplasia (VAIN). Methods The clinical data of 168 patients with histologically confirmed VAIN admitted to the First Affiliated Hospital of Bengbu Medical College from January 2019 to February 2022 were retrospectively collected. The sensitivity of different screening methods to the diagnosis of VAIN and the regression of lesions after treatment were compared. Results The average age of the patients was (49.52±11.63) years old, of which 115 cases (68.5%) were 45 years old and above, and 57.1% of the patients were postmenopausal. The screening sensitivity of cytology, HPV, colposcopy, and cytology combined with HPV were 61.5%, 92.4%, 84.6% and 95.0%, respectively. The overall sensitivity of HPV screening was significantly higher than that of cytology (P=0.001). There was no significant difference in the sensitivity of cytological screening between patients after hysterectomy and those without hysterectomy (P=0.718). The pathological coincidence rate of colposcopy was higher than that of cytology (P=0.001). There was a positive correlation between the grade of VAIN and the grade of cervical lesions (r=0.162, P=0.036). HPV16 was the most common genotype of VAIN. Among the 97 patients who were followed up after treatment, 83 patients (85.6%) had lesion degradation and regression, of which 2 patients relapsed again after regression and improved after re-treatment. Five patients (5.2%) had lesion progression, of which 1 patient with VAIN3 progressed to vaginal cancer. The prognosis of VAIN patients may be related to age. Conclusion Cytology, HPV and colposcopy can still be used as a diagnostic procedure for VAIN. After active treatment and follow-up, most patients have a good prognosis.
- Vaginal intraepithelial neoplasia,
- Human papillomavirus,
- Colposcopy,
- Treatment,
- Prognosis

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References

[1]	HOSHI-SAKAMOTO E, KISEKI H, IKEDA S I. Vaginal intraepithelial neoplasia 3 in a woman without simultaneous cervical intraepithelial neoplasm[J]. J Med Cases, 2020, 11(8): 246-248. doi: 10.14740/jmc3532
[2]	米兰, 毕蕙. 阴道镜在阴道上皮内瘤变诊治中的作用[J]. 实用妇产科杂志, 2021, 37(12): 894-897. doi: 10.3969/j.issn.1003-6946.2021.12.syfckzz202112006 MI L, BI H. The role of colposcopy in the diagnosis and treatment of vaginal intraepithelial neoplasia[J]. Journal of Practical Obstetrics and Gynecology, 2021, 37(12): 894-897. doi: 10.3969/j.issn.1003-6946.2021.12.syfckzz202112006
[3]	宋芳, 王建东, 张师前, 等. 阴道上皮内瘤变诊治专家共识(2020)[J]. 中国实用妇科与产科杂志, 2020, 36(8): 722-728. doi: 10.19538/j.fk2020080113 SONG F, WANG J D, ZHANG S Q, et al. Expert consensus on diagnosis and treatment of vaginal intraepithelial neoplasia[J]. Chinese Journal of Practical Gynecology and Obstetrics, 2020, 36(8): 722-728. doi: 10.19538/j.fk2020080113
[4]	陈丽梅, 张宏伟, 汪清, 等. 阴道内镜在隐匿性阴道顶角高级别鳞状上皮内病变诊治中的应用[J]. 中华妇产科杂志, 2021, 56(8): 569-575. doi: 10.3760/cma.j.cn112141-20210614-00324 CHEN L M, ZHANG H W, WANG Q, et al. Application of vaginoscopy in the diagnosis and treatment of occult vaginal high-grade squamous intraepithelial lesions[J]. Chinese Journal of Obstetrics and Gynecology, 2021, 56(8): 569-575. doi: 10.3760/cma.j.cn112141-20210614-00324
[5]	AO M Y, ZHENG D X, WANG J W, et al. Risk factors analysis of persistence, progression and recurrence in vaginal intraepithelial neoplasia[J]. Gynecol Oncol, 2021, 162(3): 584-589. doi: 10.1016/j.ygyno.2021.06.027
[6]	CAO D, WU D, XU Y. Vaginal intraepithelial neoplasia in patients after total hysterectomy[J]. Curr Probl Cancer, 2021, 45(3): 100687. DOI: 10.1016/j.currproblcancer.2020.100687.
[7]	张璐, 汪清, 张宏伟, 等. 4562例阴道上皮内瘤变和阴道癌的临床特征分析[J]. 现代妇产科进展, 2021, 30(9): 646-650. doi: 10.13283/j.cnki.xdfckjz.2021.09.033 ZHANG L, WANG Q, ZHANG H W, et al. Clinical features of vaginal precancer and cancer: a retrospective study of 4562 cases in China[J]. Progress in Obstetrics and Gynecology, 2021, 30(9): 646-650. doi: 10.13283/j.cnki.xdfckjz.2021.09.033
[8]	TIDY J. The risk of vaginal cancer is associated with a history of cervical neoplasia[J]. BJOG, 2020, 127(4): 455. doi: 10.1111/1471-0528.16065
[9]	范雅丽, 王建东. 宫颈病变与阴道上皮内瘤变相关性及高危因素分析[J]. 医学综述, 2018, 24(10): 1888-1891, 1897. doi: 10.3969/j.issn.1006-2084.2018.10.004 FAN Y L, WANG J D. Correlation between cervical pathological changes and vaginal intraepithelial neoplasia and analysis of risk factors[J]. Medical Recapitulate, 2018, 24(10): 1888-1891, 1897. doi: 10.3969/j.issn.1006-2084.2018.10.004
[10]	YU D, QU P P, LIU M H. Clinical presentation, treatment, and outcomes associated with vaginal intraepithelial neoplasia: a retrospective study of 118 patients[J]. J Obstet Gynaecol Res, 2021, 47(5): 1624-1630. doi: 10.1111/jog.14733
[11]	唐丹, 敖孟银, 郄明蓉. 阴道上皮内瘤变的诊治进展[J]. 实用妇产科杂志, 2021, 37(12): 881-884. https://www.cnki.com.cn/Article/CJFDTOTAL-SFCZ202112001.htm TANG D, AO M Y, XI M R. Advances in diagnosis and treatment of vaginal intraepithelial neoplasia[J]. Journal of Practical Obstetrics and Gynecology, 2021, 37(12): 881-884. https://www.cnki.com.cn/Article/CJFDTOTAL-SFCZ202112001.htm
[12]	宋昱, 隋龙, 汪清, 等. 1467例阴道上皮内瘤变的液基细胞学及HPV检测的回顾性分析[J]. 复旦学报(医学版), 2018, 45(4): 530-535. https://www.cnki.com.cn/Article/CJFDTOTAL-SHYK201804016.htm SONG Y, SUI L, WANG Q, et al. Retrospective analysis of liquid based cytology and HPV test on 1467 cases of vaginal intraepithelial neoplasia[J]. Fudan University Journal of Medical Sciences, 2018, 45(4): 530-535. https://www.cnki.com.cn/Article/CJFDTOTAL-SHYK201804016.htm
[13]	STUEBS F A, SCHULMEYER C E, MEHLHORN G, et al. Accuracy of colposcopy-directed biopsy in detecting early cervical neoplasia: a retrospective study[J]. Arch Gynecol Obstet, 2019, 299(2): 525-532. doi: 10.1007/s00404-018-4953-8
[14]	STUEBS F A, KOCH M C, MEHLHORN G, et al. Accuracy of colposcopic findings in detecting vaginal intraepithelial neoplasia: a retrospective study[J]. Arch Gynecol Obstet, 2020, 301(3): 769-777. doi: 10.1007/s00404-020-05441-5
[15]	王立群, 何玉, 李旭, 等. R-way阴道镜诊断系统在宫颈疾病诊断中的应用价值[J]. 中华全科医学, 2022, 20(10): 1704-1707, 1772. doi: 10.16766/j.cnki.issn.1674-4152.002684 WANG L Q, HE Y, LI X, et al. Clinical application value of R-way colposcopy diagnosis system in diagnosing cervical diseases[J]. Chinese Journal of General Practice, 2022, 20(10): 1704-1707, 1772. doi: 10.16766/j.cnki.issn.1674-4152.002684
[16]	毕蕙, 李明珠, 赵超, 等. 子宫颈低级别鳞状上皮内病变管理的中国专家共识[J]. 中国妇产科临床杂志, 2022, 23(4): 443-445. https://www.cnki.com.cn/Article/CJFDTOTAL-FKLC202204036.htm BI H, LI M Z, ZHAO C, et al. Chinese expert consensus on the management of low-grade squamous intraepithelial lesions of the cervix[J]. Chinese Journal of Clinical Obstetrics and Gynecology, 2022, 23(4): 443-445. https://www.cnki.com.cn/Article/CJFDTOTAL-FKLC202204036.htm
[17]	ZHANG Y C, SU Y H, TANG Y J, et al. Comparative study of topical 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) and surgery for the treatment of high-grade vaginal intraepithelial neoplasia[J]. Photodiagnosis Photodyn Ther, 2022, 39: 102958. DOI: 10.1016/j.pdpdt.2022.102958.
[18]	BOGANI G, DITTO A, FERLA S, et al. Treatment modalities for recurrent high-grade vaginal intraepithelial neoplasia[J]. Gynecol Oncol, 2019, 30(2): e20. DOI: 10.3802/jgo.2019.30.e20.
[19]	KIM M K, LEE I H, LEE K H. Clinical outcomes and risk of recurrence among patients with vaginal intraepithelial neoplasia: a comprehensive analysis of 576 cases[J]. Gynecol Oncol, 2018, 29(1): e6. DOI: 10.3802/jgo.2018.29.e6.

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Clinical features, treatment and prognosis of vaginal intraepithelial neoplasia

doi: 10.16766/j.cnki.issn.1674-4152.003067