A case study of squamous cell carcinoma of the vulva in complete remission after radical radiotherapy

The patient is a female, 80-year old, with vulvar discomfort for 2 years, with bilateral labia majora plaques and ulcers for more than 3 months. Histopathological examination of tissue biopsies showed irregular epidermal hyperplasia with infiltration into the dermis, formation of squamous cell masses with visible nuclear heterogeneity, and lymphocytic infiltration in the superficial dermis. Immunohistochemistry demonstrated that the combined positive score (CPS) of programmed death-ligand 1 (PD-L1) was 80. Nucleic acid testing for high-risk HPV typing suggested HPV16 positive (+). The woman was diagnosed with vulvar hypofractionated keratinized squamous cell carcinoma based on the aforementioned evidence. The patient was greatly improved after radical radiotherapy, with manifestations of complete regression of the original large skin lesion and basic relief of symptoms, and required no further surgery or targeted immunotherapy, since the treatment effect met the criteria for radical tumor treatment. No significant radiotherapy-related side effects or tumor recurrence were observed during the follow-up period.