Volume 21 Issue 8
Aug.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(8): 1291-1294
XI Ting, YAO Xiaoguang, WANG Yingchun, YAO Ling, LI Nanfang. Clinical characteristics of mild cognitive impairment in patients with hypertension and obstructive sleep apnea syndrome[J]. Chinese Journal of General Practice, 2023, 21(8): 1291-1294. doi: 10.16766/j.cnki.issn.1674-4152.003105
Citation: XI Ting, YAO Xiaoguang, WANG Yingchun, YAO Ling, LI Nanfang. Clinical characteristics of mild cognitive impairment in patients with hypertension and obstructive sleep apnea syndrome[J]. Chinese Journal of General Practice, 2023, 21(8): 1291-1294. doi: 10.16766/j.cnki.issn.1674-4152.003105
shu

Clinical characteristics of mild cognitive impairment in patients with hypertension and obstructive sleep apnea syndrome

doi: 10.16766/j.cnki.issn.1674-4152.003105

  • Hypertension Center of People' s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Urumqi, Xinjiang 830001, China

Funds:

 WJWY-202201

 20200102

  • Received Date: 2022-08-15
    Available Online: 2023-09-13
    Abstract
  •   Objective  To investigate the clinical features and associated risk factors of mild cognitive impairment (MCI) in patients with hypertension and obstructive sleep apnea syndrome (OSAS).  Methods  A total of 120 patients with hypertension who were hospitalized in the People' s Hospital of Xinjiang Uygur Autonomous Region from April to October 2021 and completed overnight polysomnographic monitoring or diagnosis of OSAS were consecutively selected. All patients were evaluated by 24-hour ambulatory blood pressure and Montreal cognitive assessment scale (MoCA), and MoCA score < 26 was defined as MCI. The characteristics of sleep parameters and ambulatory blood pressure were compared between the cognitively normal group (39 cases) and the MCI group (81 cases), and associated risk factors were discussed.  Results  The detection rate of MCI in the general population was 67.5%(81/120); Compared with the normal cognitive function group, the nighttime minimum oxygen saturation[81.0(77.0, 85.0)% vs.86.0(79.0, 88.0)%] decreased in the MCI group, while AHI[20.1(15.3, 31.6) times/h vs. 6.7(2.6, 26.1) times/h], T90[27.2(5.3, 80.4) min vs. 6.9(0.4, 79.1) min], in visual space/execution function[3(2, 3) points vs. (4(3, 5) points], attention [5(5, 6) points vs. 6(6, 6) points], delay recall [2(1, 3) points vs.3(3, 4) points], abstract thinking [1(0, 1) points vs.2(1, 2) points], cognitive domains were significantly reduced (all P < 0.05). Multivariate logistic regression showed that the lowest oxygen saturation at night was independent risk factor for MCI in this population.  Conclusion  The high prevalence of MCI in hypertensive patients with OSAS, short education and low nocturnal minimum oxygen saturation are the risk factors for the high prevalence of MCI in this population.

     

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