The effect of lipid metabolism on the occurrence, development and prognosis of aortic disease

WANG Yuhang; SHEN Zhenya

doi:10.16766/j.cnki.issn.1674-4152.003126

Volume 21 Issue 8

Aug. 2023

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Article Navigation > Chinese Journal of General Practice > 2023 > 21(8): 1374-1378

WANG Yuhang, SHEN Zhenya. The effect of lipid metabolism on the occurrence, development and prognosis of aortic disease[J]. Chinese Journal of General Practice, 2023, 21(8): 1374-1378. doi: 10.16766/j.cnki.issn.1674-4152.003126

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WANG Yuhang, SHEN Zhenya. The effect of lipid metabolism on the occurrence, development and prognosis of aortic disease[J]. Chinese Journal of General Practice, 2023, 21(8): 1374-1378. doi: 10.16766/j.cnki.issn.1674-4152.003126

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The effect of lipid metabolism on the occurrence, development and prognosis of aortic disease

doi: 10.16766/j.cnki.issn.1674-4152.003126

WANG Yuhang
, SHEN Zhenya^,

Department of Cardiovascular Surgery, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China

Funds:

91839101

Received Date: 2023-02-23
Available Online: 2023-09-13

Abstract

Abstract

Aortic diseases, such as aortic aneurysm and aortic dissection, have attracted wide attention as a kind of diseases with high morbidity and high mortality, which lack effective early warning markers and have a high mortality after surgical treatment. The pathogenesis of aortic disease is not fully understood. At present, aortic disease has been proven to be associated with hypertension, atherosclerosis, gender, genetic variation, inflammation and other factors that change the force on the aortic wall. With the development of economy and society, the incidence of dyslipidemia represented by hyperlipidemia is increasing in the world. Dyslipidemia increases the risk of atherosclerosis and vascular dysfunction, and ultimately leads to coronary heart disease, stroke and other cardiovascular and cerebrovascular diseases. Currently, hyperlipidemia has been found to have adverse effects on the occurrence and development of aortic diseases. A better understanding of the relationship between lipid metabolism disorders and aortic diseases is helpful for clinical prevention, diagnosis and treatment of aortic diseases. At the same time, various lipid-regulating drugs can effectively control blood lipid through different lipid metabolic sites, and lipid-regulating drugs have played an important role in the prevention and clinical treatment of various cardiovascular and cerebrovascular diseases. Controlling blood lipids and improving atherosclerosis have better preventive effect on the occurrence of aortic diseases. This paper summarizes the relationship between clinical lipid indexes, hyperlipidemia and the occurrence, development and prognosis of aortic diseases in recent years, and probes into the cellular and molecular pathways of lipid metabolism disorders and the effects of lipid-regulating drugs on aortic diseases, as well as their potential application prospects.
- Aortic disease,
- Lipid metabolism,
- Hyperlipidemia,
- Lipid-regulating drug,
- Pathogenesis

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References(43)

References

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The effect of lipid metabolism on the occurrence, development and prognosis of aortic disease

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