Volume 21 Issue 12
Dec.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(12): 2018-2021
ZHANG Chaoyang, YANG Zi, LI Hongtao, ZHANG Wenjing, ZHAO Meng, WANG Juan, ZUO Lugen, ZHANG Xiaofeng. The relationship between CD13 expression and clinicopathological parameters in gastric cancer and its predictive value for long term prognosis[J]. Chinese Journal of General Practice, 2023, 21(12): 2018-2021. doi: 10.16766/j.cnki.issn.1674-4152.003280
Citation: ZHANG Chaoyang, YANG Zi, LI Hongtao, ZHANG Wenjing, ZHAO Meng, WANG Juan, ZUO Lugen, ZHANG Xiaofeng. The relationship between CD13 expression and clinicopathological parameters in gastric cancer and its predictive value for long term prognosis[J]. Chinese Journal of General Practice, 2023, 21(12): 2018-2021. doi: 10.16766/j.cnki.issn.1674-4152.003280
shu

The relationship between CD13 expression and clinicopathological parameters in gastric cancer and its predictive value for long term prognosis

doi: 10.16766/j.cnki.issn.1674-4152.003280
  • 1.

    Clinical Trials Center, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 81700476

 KFDX202202

  • Received Date: 2023-06-28
    Available Online: 2024-01-29
    Abstract
  •   Objective  To analyze the expression of alanyl (membrane) aminopeptidase (CD13) in gastric cancer tissues and its relationship with clinicopathological parameters, and to evaluate its value in predicting the long-term prognosis of patients with gastric cancer.  Methods  A total of 117 patients who underwent radical gastrectomy in the First Affiliated Hospital of Bengbu Medical College from January 2015 to January 2018 were included. Immunohistochemistry was used to analyze the expression of CD13 in gastric cancer tissues and evaluate the relationship between CD13 and clinicopathological parameters, as well as the predictive value of CD13 on the 5-year postoperative survival rate of patients.  Results  The expression of CD13 in gastric cancer tissues was significantly higher than that in adjacent tissues (P < 0.001). Patients were divided into a high CD13 expression group (n=59) and a low CD13 expression group (n=58) based on the median relative expression of CD13 (4.25). The proportion of patients with CEA≥5 μg/L, vascular infiltration, T stages 3-4, N stages 2-3, and pathological grade 3-4 in the CD13 high expression group was significantly higher than that in the low expression group (all P < 0.05). KM survival curve analysis showed that the 5-year survival rate of patients with high CD13 expression was significantly lower than that of patients with low CD13 expression (P < 0.001). KM analysis and Cox multivariate analysis showed that high expression of CD13 (HR=2.125, 95% CI: 1.256-3.595) was an independent risk factor for the 5-year survival rate of gastric cancer patients after surgery. ROC curve analysis showed that with the relative expression level of CD13 4.22 as the cut-off value, the sensitivity, specificity and accuracy of predicting death 5 years after surgery in gastric cancer patients were 75.71%, 93.62% and 0.881 (P < 0.001).  Conclusion  CD13 is highly expressed in gastric cancer tissues and is closely related to clinicopathological parameters. It is an independent risk factor for the 5-year postoperative survival rate of gastric cancer patients and has certain predictive value for prognosis assessment.

     

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