Volume 21 Issue 12
Dec.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(12): 2036-2039
CHENG Fang, SHEN Wangfang, HUANG Xinrui, ZHANG Yaohong, MAO Xiaopei. Current status and influencing factors analysis of adverse reactions in hematopoietic stem cell infusion[J]. Chinese Journal of General Practice, 2023, 21(12): 2036-2039. doi: 10.16766/j.cnki.issn.1674-4152.003284
Citation: CHENG Fang, SHEN Wangfang, HUANG Xinrui, ZHANG Yaohong, MAO Xiaopei. Current status and influencing factors analysis of adverse reactions in hematopoietic stem cell infusion[J]. Chinese Journal of General Practice, 2023, 21(12): 2036-2039. doi: 10.16766/j.cnki.issn.1674-4152.003284
shu

Current status and influencing factors analysis of adverse reactions in hematopoietic stem cell infusion

doi: 10.16766/j.cnki.issn.1674-4152.003284
  • 1.

    Department of Hematology, the First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang 310006, China

Funds:

 2023KY139

 2023ZL408

  • Received Date: 2023-01-23
    Available Online: 2024-01-29
    Abstract
  •   Objective  To investigate the current situation and influencing factors of adverse reactions of hematopoietic stem cell infusion, and to provide a basis for the construction of a safe infusion program for hematopoietic stem cells.  Methods  A total of 389 patients with hematological diseases who underwent hematopoietic stem cell transplantation at a tertiary Grade A hospital's Bone Marrow Transplantation Center in Zhejiang Province between January 2017 and July 2022 were selected as the study population. Data collection involved the use of general information questionnaire and adverse reaction assessment forms.  Results  Among the 389 patients who underwent hematopoietic stem cell infusion, the overall incidence of adverse reactions was 31.11% (121/389). Specially, allogeneic transplant recipients experienced an incidence of 34.04% (97/285), while autologous transplant recipients had an incidence of 23.08% (24/104). The cardiovascular system exhibited the highest occurrence of adverse reactions, accounting for 89 cases (52.35% of all adverse events). Univariate analysis showed that age, gender, transplantation type, stem cell source, human leukocyte antigen matching, CD34+ cell count, and infusion rate significantly influenced adverse reactions in hematopoietic stem cell transplantation (all P < 0.05). Furthermore, multivariate logistic regression analysis identified older age (OR=1.121, P < 0.001), stem cell source (bone marrow stem cell, OR=2.836, P=0.007), human leukocyte antigen mismatch between donor and recipient (OR=0.110, P < 0.001), and fast infusion rate of stem cell (OR=2.107, P < 0.001) as independent risk factors for adverse reactions of hematopoietic stem cell transplantation.  Conclusion  The occurrence in adverse reactions of hematopoietic stem cell infusion is relatively high with older age, bone marrow fast infusion rate of stem cell, incomplete human leukocyte antigen matching between donor and recipient, and high infusion rate identified as influencing factors. Preventive interventions should be implemented to reduce the occurrence of adverse reactions in hematopoietic stem cell infusion.

     

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    • References(20)
  • [1]
    NAKAMURA Z M, NASH R P, QUILLEN L J, et al. Psychiatric care in hematopoietic stem cell transplantation[J]. Psychosomatics, 2019, 60(3): 227-237. doi: 10.1016/j.psym.2019.01.005
    [2]
    中华医学会血液学分会干细胞应用学组. 中国异基因造血干细胞移植治疗血液系统疾病专家共识(Ⅲ): 急性移植物抗宿主病(2020年版)[J]. 中华血液学杂志, 2020, 41(7): 529-536.

    Stem cell Application Group, Society of Hematology, Chinese Medical Association. Chinese consensus of allogeneic hematopoietic stem cell transplantation for hematological disease(Ⅲ)—acute graft-versus-host disease(2020)[J]. Chinese Journal of Hematology, 2020, 41(7): 529-536.
    [3]
    张莺莺, 潘萍, 李瑶, 等. 接纳承诺护理疗法在造血干细胞移植患者中的应用效果[J]. 中华现代护理杂志, 2021, 27(4): 512-516.

    ZHANG Y Y, PAN P, LI Y, et al. Application effect of acceptance and commitment nursing therapy in patients with hematopoietic stem cell transplantation[J]. Chinese Journal of Modern Nursing, 2021, 27(4): 512-516.
    [4]
    王营营. 造血干细胞移植患者心理韧性的影响因素及中介效应分析[D]. 合肥: 安徽医科大学, 2019.

    WANG Y Y. Analysis of influencing factors and mediating effects of mental toughness in patients with hematopoietic stem cell transplantation[D]. Hefei: Anhui Medical University, 2019.
    [5]
    SAAD A, DE LIMA M, ANAND S, et al. Hematopoietic cell transplantation, version 2.2020, nccn clinical practice guidelines in oncology[J]. J Natl Compr Canc Netw, 2020, 18(5): 599-634. doi: 10.6004/jnccn.2020.0021
    [6]
    IKEDA K, OHTO H, OKUYAMA Y, et al. Adverse events associated with infusion of hematopoietic stem cell products: a prospective and multicenter surveillance study[J]. Transfus Med Rev, 2018, 39: 382.
    [7]
    IKEDA K, OHTO H, YAMADA-FUJIWARA M, et al. Hematopoietic cell infusion-related adverse events in pediatric/small recipients in a prospective/multicenter study[J]. Transfusion, 2020, 60(5): 1015-1023. doi: 10.1111/trf.15786
    [8]
    张红, 李凤霞, 王艳平, 等. 血液病患者脐血干细胞输入3小时内不良反应观察与分析[J]. 护理学杂志, 2021, 36(21): 32-34. doi: 10.3870/j.issn.1001-4152.2021.21.032

    ZHANG H, LI F X, WANG Y P, et al. Observation and analysis of adverse reactions occurring within 3 hours of infusion of umbilical cord blood-derived mesenchymal stem cells in patients with hematologic diseases[J]. Journal of Nursing Science, 2021, 36(21): 32-34. doi: 10.3870/j.issn.1001-4152.2021.21.032
    [9]
    VIDULA N, VILLA M, HELENOWSKI I B, et al. Adverse events during hematopoietic stem cell infusion: analysis of the infusion product[J]. Clin Lymphoma Myeloma Leuk, 2015, 15(11): 157-162. doi: 10.1016/j.clml.2015.08.085
    [10]
    Cancer Therapy Evaluation Program. Common terminology criteria for adverse events[EB/OL]. [2021-04-19]. https://ctep.cancer.gov/protocoldevelopment/electronic_applications/ctc.htm#ctc_60.
    [11]
    KOLLERUP MADSEN B, HILSCHER M, ZETNER D, et al. Adverse reactions of dimethyl sulfoxide in humans: a systematic review[J]. F1000Res, 2018, 7: 1746. DOI: 10.12688/f1000research.16642.2.
    [12]
    WENG L, BEAUCHESNE P R. Dimethyl sulfoxide-free cryopreservation for cell therapy: a review[J]. Cryobiology, 2020, 94: 9-17. doi: 10.1016/j.cryobiol.2020.03.012
    [13]
    GILFANOVA R, CALLEGARI A, CHILDS A, et al. A bioinspired and chemically defined alternative to dimethyl sulfoxide for the cryopreservation of human hematopoietic stem cells[J]. Bone Marrow Transpl, 2021, 56(11): 2644-2650. doi: 10.1038/s41409-021-01368-w
    [14]
    吕素玲, 林向东, 陈茹, 等. 老年血液透析患者自我管理能力对跌倒恐惧的影响研究[J]. 中华全科医学, 2022, 20(8): 1343-1345, 1379. doi: 10.16766/j.cnki.issn.1674-4152.002592

    LYU S L, LIN X D, CHEN R, et al. Effect of self-management ability on fall fear in elderly patients undergoing haemodialysis[J]. Chinese Journal of General Practice, 2022, 20(8): 1343-1345, 1379. doi: 10.16766/j.cnki.issn.1674-4152.002592
    [15]
    谭树凤, 沈红卫, 李桃, 等. 上海市浦东新区某社区老年人群体检结果及5年随访分析[J]. 中华全科医学, 2022, 20(10): 1715-1717, 1785. doi: 10.16766/j.cnki.issn.1674-4152.002687

    TAN S F, SHEN H W, LI T, et al. Healthy examination results and 5-year follow-up analysis of the elderly in a community of Pudong New Area, Shanghai[J]. Chinese Journal of General Practice, 2022, 20(10): 1715-1717, 1785. doi: 10.16766/j.cnki.issn.1674-4152.002687
    [16]
    姬长珍, 王慧媛, 毛显春. 老年住院患者营养状况与衰弱关系的研究[J]. 北京医学, 2021, 43(11): 1123-1125.

    JI C Z, WANG H Y, MAO X C. Relationship between frailty and malnutrition in elderly inpatients[J]. Beijing Medical Journal, 2021, 43(11): 1123-1125.
    [17]
    党红星, 许峰. 输血相关的循环超负荷及急性肺损伤[J]. 中国实用儿科杂志, 2020, 35(12): 947-953.

    DANG H X, XU F. Transfusion-associated circulatory overload and transfusion-related acute lung injury[J]. Chinese Journal of Practical Pediatrics, 2020, 35(12): 947-953.
    [18]
    KISSOON T, GODDER K, FORT J. Infusion of hematopoietic stem cell products using pump mechanism: an approach worth consideration[J]. J Pediatr Hematol Oncol, 2020, 42(3): e174-e176. doi: 10.1097/MPH.0000000000001491
    [19]
    KIDERLEN TR, RONNEBURGER L, MARRETTA L, et al. Retrospective comparison of reinfusion procedures and subsequent leukopenia in autologous stem cell transplantation[J]. Int J Hematol, 2021, 114(4): 459-463. doi: 10.1007/s12185-021-03196-6
    [20]
    KLANDERMAN R B, WIJNBERGE M, BOSBOOM J J, et al. Differential effects of speed and volume on transfusion-associated circulatory overload: a randomized study in rats[J]. Vox Sang, 2022, 117(3): 371-378. doi: 10.1111/vox.13191
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