Volume 21 Issue 12
Dec.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(12): 2086-2088
BAI Min, HUANG Lieping, ZHU Bei, WU Jinhua, WU Qiong, HONG Kaiting, YU Youna. Mediating effect of leptin levels between insulin resistance and nonalcoholic fatty liver disease in obese children[J]. Chinese Journal of General Practice, 2023, 21(12): 2086-2088. doi: 10.16766/j.cnki.issn.1674-4152.003296
Citation: BAI Min, HUANG Lieping, ZHU Bei, WU Jinhua, WU Qiong, HONG Kaiting, YU Youna. Mediating effect of leptin levels between insulin resistance and nonalcoholic fatty liver disease in obese children[J]. Chinese Journal of General Practice, 2023, 21(12): 2086-2088. doi: 10.16766/j.cnki.issn.1674-4152.003296
shu

Mediating effect of leptin levels between insulin resistance and nonalcoholic fatty liver disease in obese children

doi: 10.16766/j.cnki.issn.1674-4152.003296
  • 1.

    Department of Pediatrics, Zhoushan Women's and Children's Hospital, Zhoushan, Zhejiang 316000, China

Funds:

 2023KY1305

  • Received Date: 2023-05-24
    Available Online: 2024-01-29
    Abstract
  •   Objective  Paediatric non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and its prevalence is increasing with the rise in overweight and obesity. Leptin was the first adipokine to be isolated and identified. Therefore, the mediating role of leptin levels between insulin resistance and NAFLD in obese children is discussed.  Methods  Eighty obese children admitted to Zhoushan Women's and Children's Hospital from January 2022 to March 2023 were selected as research objects, and divided into NAFLD group (32 cases) and non-NAFLD group (48 cases) according to the presence or absence of NAFLD. General data, physical data, insulin resistance index, leptin level and liver function of all subjects were collected, and Pearson correlation was used to analyze the correlation between the above variables. Mediation effects were used to analyze the effects of leptin levels on insulin resistance and non-alcoholic fatty liver disease in obese children.  Results  Homeostasis model assessment forinsulin resistance (HOMA-IR), leptin, alanine transaminase (ALT), aspartate transaminase (AST) and intrahepatic lipiol (IHL) levels in the NAFLD group were higher than those in the non-NAFLD group (all P < 0.05). Pearson correlation showed that HOMA-IR was positively correlated with leptin and IHL (r=0.573, P < 0.001; r=0.577, P < 0.001); leptin was positively correlated with IHL (r=0.557, P < 0.001). Mediation effect analysis showed that HOMA-IR as a direct effect accounted for 56.48% (0.340) of the total effect and adipokines as a mediating effect accounted for 43.52% (0.262).  Conclusion  Insulin resistance in obese children is associated with non-alcoholic fatty liver disease, which may be mediated by adipokines.

     

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