Volume 23 Issue 1
Jan.  2025
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FENG Ying, HU Meigui, CHENG Yiju, FAN Maofei. Prevalence and risk factors of pulmonary nodules among the occupational population in Anshun[J]. Chinese Journal of General Practice, 2025, 23(1): 26-30. doi: 10.16766/j.cnki.issn.1674-4152.003828
Citation: FENG Ying, HU Meigui, CHENG Yiju, FAN Maofei. Prevalence and risk factors of pulmonary nodules among the occupational population in Anshun[J]. Chinese Journal of General Practice, 2025, 23(1): 26-30. doi: 10.16766/j.cnki.issn.1674-4152.003828
shu

Prevalence and risk factors of pulmonary nodules among the occupational population in Anshun

doi: 10.16766/j.cnki.issn.1674-4152.003828
  • 1.

    Department of Respiratory and Critical Care Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550000, China

Funds:

 gzwkj2023-126

  • Received Date: 2023-12-03
    Available Online: 2025-02-13
    Abstract
  •   Objective  As the most common clinical indicator of early lung cancer, the early detection of pulmonary nodules is crucial for lung cancer prevention and treatment. Based on the screening cohort of respiratory diseases in Anshun city, this study analyzed the characteristics of pulmonary nodules in the occupational population and explored associated risk factors. The findings aim to support efforts in the prevention and treatment of lung cancer, and to improve management of individuals with pulmonary nodules in this region.  Methods  A total of 2 730 occupational individuals who underwent low-dose spiral computed tomography (LDCT) chest screening from June 2022 to December 2023 at Anshun People ' s Hospital were selected as research subjects. Demographic data and personal habits of these research subjects were collected through questionnaires at the beginning of the study. The questionnaire data were combined with imaging characteristics of the pulmonary nodules to explore risk factors for pulmonary nodules and positive nodules.  Results  (1) A total of 1 921 occupational individuals (70.36%) were found to have pulmonary nodules. Of these, 914 had positive nodules (33.48%). Miners had the highest prevalence of pulmonary nodules. (2) Risk factors of pulmonary nodules included being male, married, having a junior high school education, smoking, exposure to second-hand smoking, cooking without a range hood, exposure to hazardous substances for more than one year, and having parents with respiratory disease. (3) The number and location of pulmonary nodules varied among occupational groups, through no significant differences were observed in texture, size, or positivity across groups. (4) Cooking without a range hood, age over 50 years old, and smoking index more than 30 pack-years were independent risk factors for positive nodules among traffic police. For miners, smoking index more than 30 pack years and age over 50 years old were independent risk factors. Cooking without a range hood was the sole independent risk factor for positive nodules among sanitation workers and drivers.  Conclusion  Pulmonary nodules are highly prevalent in occupational individuals. Being male, married, smoking, exposure to second-hand smoking, exposure to hazardous substances, and a family history of respiratory disease are independent risk factors of pulmonary nodules. The number and location of pulmonary nodules among different occupational groups. Cooking without a range hood is a universal independent risk factor of positive nodules across all occupational individuals.

     

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    • References(32)
  • [1]
    SUNG H, FEERLAY J, SIEGEL R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249. doi: 10.3322/caac.21660
    [2]
    CAO W, CHEN H D, YU Y W, et al. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020[J]. Chin Med J (Engl), 2021, 134(7): 783-791. doi: 10.1097/CM9.0000000000001474
    [3]
    OUDKERK M, LIU S, HEUVELMANS M A, et al. Lung cancer LDCT screening and mortality reduction-evidence, pitfalls and future perspectives[J]. Nat Rev Clin Oncol, 2021, 18(3): 135-151. doi: 10.1038/s41571-020-00432-6
    [4]
    MAZZONE P J, SILVESTRI G A, SOUTER L H, et al. Screening for lung cancer: CHEST guideline and expert panel report[J]. Chest, 2021, 160(5): e427-e494. doi: 10.1016/j.chest.2021.06.063
    [5]
    International Early Lung Cancer Action Program Investigators, HENSCHKE C I, YANKELEVITZ D F, et al. Survival of patients with stage Ⅰ lung cancer detected on CT screening[J]. N Engl J Med, 2006, 355(17): 1763-1771. doi: 10.1056/NEJMoa060476
    [6]
    National Lung Screening Trial Research Team, ABERLE D R, ADAMS A M, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening[J]. N Engl J Med, 2011, 365(5): 395-409. doi: 10.1056/NEJMoa1102873
    [7]
    DE K H J, VAN D A C, DE J P, et al. Reduced lung-cancer mortality with volume CT screening in a randomized trial[J]. N Engl J Med, 2020, 382(6): 503-513. doi: 10.1056/NEJMoa1911793
    [8]
    CHELALA L, HOSSAIN R, KAZEROONI E A, et al. Lung-RADS version 1.1: challenges and a look ahead, from the AJR special series on radiology reporting and data systems[J]. AJR Am J Roentgenol, 2021, 216(6): 1411-1422. doi: 10.2214/AJR.20.24807
    [9]
    中华预防医学会. 中国肺癌筛查标准(T/CPMA 013-2020)[J]. 中华肿瘤杂志, 2021, 43(1): 1-7.

    Chinese Preventive Medicine Association. Lung cancer screening guideline of China(T/CPMA 013-2020)[J]. Chinese Journal of Oncology, 2021, 43(1): 1-7.
    [10]
    中华医学会肿瘤学分会, 中华医学会杂志社. 中华医学会肺癌临床诊疗指南(2022版)[J]. 中华肿瘤杂志, 2022, 44(6): 457-490. doi: 10.3760/cma.j.cn112152-20220413-00255

    Oncology Society of Chinese Medical Association, Chinese Medical Association Publishing House. Chinese Medical Association guideline for clinical diagnosis and treatment of lung cancer(2022 edition)[J]. Chinese Journal of Oncology, 2022, 44(6): 457-490. doi: 10.3760/cma.j.cn112152-20220413-00255
    [11]
    AU-YONG I T H, HAMILTON W, RAWLINSON J, et al. Pulmonary nodules[J]. BMJ, 2020, 371: m3673. DOI: 10.1136/bmj.m3673.
    [12]
    李鑫, 冯小双, 张愉涵, 等. 肺癌社区高危人群队列研究进展[J]. 中华流行病学杂志, 2021, 42(7): 1174-1178. doi: 10.3760/cma.j.cn112338-20210118-00041

    LI X, FENG X S, ZHANG Y H, et al. Progress in cohort study of lung cancer in high-risk population in communities[J]. Chinese Journal of Epidemiology, 2021, 42(7): 1174-1178. doi: 10.3760/cma.j.cn112338-20210118-00041
    [13]
    周清华, 范亚光, 王颖, 等. 中国肺部结节分类、诊断与治疗指南(2016年版)[J]. 中国肺癌杂志, 2016, 19(12): 793-798. doi: 10.3779/j.issn.1009-3419.2016.12.12

    ZHOU Q H, FAN Y G, WANG Y, et al. China National Guideline of Classification, Diagnosis and Treatment for Lung Nodules(2016 Version)[J]. Chinese Journal of Lung Cancer, 2016, 19(12): 793-798. doi: 10.3779/j.issn.1009-3419.2016.12.12
    [14]
    包爱华, 郭海英, 何之彦, 等. 上海市松江城区某社区老年居民肺部结节的发生率和易发因素分析[J]. 临床肺科杂志, 2019, 24(6): 1061-1065. doi: 10.3969/j.issn.1009-6663.2019.06.025

    BA A H, GUO H Y, HE Z Y, et al. Incidence and high-susceptibility factors of pulmonary nodules in residents of a certain community in Songjiang District, Shanghai[J]. Journal of Clinical Pulmonary Medicine, 2019, 24(6): 1061-1065. doi: 10.3969/j.issn.1009-6663.2019.06.025
    [15]
    SWENSEN S J, JETT J R, HARTMAN T E, et al. CT screening for lung cancer: five-year prospective experience[J]. Radiology, 2005, 235(1): 259-265. doi: 10.1148/radiol.2351041662
    [16]
    PEDERSEN J H, ASHRAF H, DIRKSEN A, et al. The Danish randomized lung cancer CT screening trial: overall design and results of the prevalence round[J]. J Thorac Oncol, 2009, 4(5): 608-614. doi: 10.1097/JTO.0b013e3181a0d98f
    [17]
    鱼涛, 张雪艳, 王忠旭, 等. 不同粒径谱汽油发动机尾气气-液界面染毒对BEAS-2B细胞存活率的影响[J]. 中华劳动卫生职业病杂志, 2017, 35(6): 414-421. doi: 10.3760/cma.j.issn.1001-9391.2017.06.004

    YU T, ZHANG X Y, WANG Z X, et al. Evaluation of the viability of BEAS-2B cells exposed to gasoline engine exhaust with different particle sizes by air-liquid interface[J]. Chinese Journal of Industrial Hygiene and Occupational Diseases, 2017, 35(6): 414-421. doi: 10.3760/cma.j.issn.1001-9391.2017.06.004
    [18]
    杭文璐, 李婉君, 许乘铭, 等. 煤工尘肺患者肺结节检出状况和高危结节危险因素分析[J]. 工业卫生与职业病, 2024, 50(1): 31-35.

    HANG W L, LI W J, XU C M, et al. Prevalence of pulmonary nodules in patients of coal worker's pneumoconiosis and analysis of risk factors of high-risk nodules[J]. Industrial Health and Occupational Diseases, 2024, 50(1): 31-35.
    [19]
    孟珊, 惠东明, 王坤, 等. 基于影像组学的煤工尘肺结节分析联合临床因素预测肺癌发生的价值[J]. 中华全科医学, 2023, 21(1): 10-14.

    ME S, HUI D M, WANG K, et al. Value of analysis of coal workers ' pneumoconiosis nodules based on radiomics combined with clinical factors in predicting the occurrence of lung cancer[J]. Chinese Journal of General Practice, 2023, 21(1): 10-14.
    [20]
    FANG R, YANG Y, HAN H C, et al. Analysis of risk factors for stage I lung adenocarcinoma using low-dose high-resolution computed tomography[J]. Oncol Lett, 2018, 16(2): 2483-2489.
    [21]
    曹洪丽, 于盼盼, 刘自金, 等. 幽门螺旋杆菌感染与肺结节及其危险因素相关性分析研究[J]. 解放军预防医学杂志, 2021, 39(1): 84-86.

    CAO H L, YU P P, LIU Z J, et al. Analysis of correlation between helicobacter pylori infection and pulmonary nodules and their risk factors[J]. Journal of Preventive Medicine of Chinese People ' s Liberation Army, 2021, 39(1): 84-86.
    [22]
    PHUA C K, SIM W Y, SEN T K, et al. Evaluation of pulmonary nodules in Asian population[J]. J Thorac Dis, 2016, 8(5): 950-957.
    [23]
    徐国厚, 黄海峡, 陈斌, 等. 单体检中心23 695例体检者首次胸部低剂量CT筛查结果及肺结节相关易感因素的研究[J]. 复旦学报(医学版), 2020, 47(5): 654-659, 668.

    XU G H, HUANG H X, CHEN B, et al. A study on the first chest low-dose CT screening and susceptible factors of pulmonary nodules in 23695 physical examinees in a medical examination center[J]. Fudan University Journal of Medical Sciences, 2020, 47(5): 654-659, 668.
    [24]
    廖俊蕾, 柳弥. 健康体检人群胸部低剂量螺旋CT检出肺部结节及肺癌情况研究[J]. 临床肺科杂志, 2020, 25(11): 1722-1724, 1728.

    LIU J L, LIU M. Analysis of the result of pulmonary nodules and lung cancer detected by low-dose spiral CT in healthy examination people[J]. Journal of Clinical Pulmonary Medicine, 2020, 25(11): 1722-1724, 1728.
    [25]
    MACMAHON H, NAIDICH D P, GOO J M, et al. Guidelines for management of incidental pulmonary nodules detected on CT images: from the fleischner society 2017[J]. Radiology, 2017, 284(1): 228-243.
    [26]
    YANG D W, LIU Y, BAI C X, et al. Epidemiology of lung cancer and lung cancer screening programs in China and the United States[J]. Cancer Letter, 2020, 468: 82-87.
    [27]
    ZHONG L, GOLDBERG M S, PARENT M E, et al. Exposure to environmental tobacco smoke and the risk of lung cancer: a meta-analysis[J]. Lung Cancer, 2000, 27(1): 3-18. http://www.sciencedirect.com/science?_ob=ShoppingCartURL&_method=add&_eid=1-s2.0-S0169500299000938&originContentFamily=serial&_origin=article&_ts=1432343595&md5=ba5becff97c8b3ff9f858553f5eb2230
    [28]
    ZENG H M, CHEN W Q, ZHENG R S, et al. Changing cancer survival in China during 2003-15: a pooled analysis of 17 population-based cancer registries[J]. Lancet Glob Health, 2018, 6(5): e555-e567.
    [29]
    JIA P L, ZHANG C, YU J J, et al. The risk of lung cancer among cooking adults: a meta-analysis of 23 observational studies[J]. J Cancer Res Clin Oncol, 2018, 144(2): 229-240.
    [30]
    李运, 陈克终, 隋锡朝, 等. 孤立性肺结节良恶性判断数学预测模型的建立[J]. 北京大学学报(医学版), 2011, 43(3): 450-454.

    LI Y, CHEN K Z, SUI X Z, et al. Establishment of a mathematical prediction model to evaluate the probability of malignancy or benign in patients with solitary pulmonary nodules[J]. Journal of Peking University: Health Sciences, 2011, 43(3): 450-454.
    [31]
    王通, 修语池, 王彬, 等. 肺磨玻璃样结节危险因素分析[J]. 临床军医杂志, 2020, 48(7): 846-847.

    WANG T, XIU Y C, WANG B, et al. Risk factors analysis of ground glass pulmonary nodule[J]. Clinical Journal of Medical Officers, 2020, 48(7): 846-847.
    [32]
    孙新然, 赵红, 赵大海, 等. 基于CT影像组学构建模型对实性肺结节鉴别的价值[J]. 中华全科医学, 2023, 21(1): 15-18, 91. doi: 10.16766/j.cnki.issn.1674-4152.002801

    SUN X R, ZHAO H, ZHAO D H, et al. The value of establishing a model in the differentiation of solid pulmonary nodules based on CT radiomics[J]. Chinese Journal of General Practice, 2023, 21(1): 15-18, 91. doi: 10.16766/j.cnki.issn.1674-4152.002801
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