Volume 23 Issue 1
Jan.  2025
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(1): 36-39
BAO Hongdan, ZHOU Yafen, SHI Qiongyao, GUO Jingyi, ZHANG Zhenlin, GAO Chao. Analysis of 25-hydroxyvitamin D levels and its association with bone turnover markers and bone mineral density in Xiangshan County adults[J]. Chinese Journal of General Practice, 2025, 23(1): 36-39. doi: 10.16766/j.cnki.issn.1674-4152.003830
Citation: BAO Hongdan, ZHOU Yafen, SHI Qiongyao, GUO Jingyi, ZHANG Zhenlin, GAO Chao. Analysis of 25-hydroxyvitamin D levels and its association with bone turnover markers and bone mineral density in Xiangshan County adults[J]. Chinese Journal of General Practice, 2025, 23(1): 36-39. doi: 10.16766/j.cnki.issn.1674-4152.003830
shu

Analysis of 25-hydroxyvitamin D levels and its association with bone turnover markers and bone mineral density in Xiangshan County adults

doi: 10.16766/j.cnki.issn.1674-4152.003830
  • 1.

    Department of Endocrinology, Ningbo Fourth People' s Hospital, Ningbo, Zhejiang 315700, China

Funds:

 81900808

  • Received Date: 2024-02-01
    Available Online: 2025-02-13
    Abstract
  •   Objective  To investigate the level and deficiency of 25-hydroxyvitamin D [25(OH)D] in adults living in Xiangshan County, Ningbo City, and to analyze the association between 25(OH)D levels with bone turnover markers (BTMs) and bone mineral density (BMD).  Methods  From August to November 2020, 3 117 volunteers were recruited from Xiangshan County, Ningbo City, including 1 122 males and 1 995 females, with an age range of 22-95 years old. Serum samples were collected for 25(OH)D and BTMs detection. BMD of the lumbar spine, femoral neck, and total hip of the subjects were measured by dual-energy X-ray absorptiometry.  Results  The proportion of 25(OH)D insufficiency and deficiency in the study population was 39.7% (1 236/3 117) and 9.1% (284/3 117), respectively. After grouping by age, the proportion of 25(OH)D deficiency was highest in men and women under 50 years of age, with 11.1% (21/189) and 31.0% (139/449), respectively. After grouping by gender, 25(OH)D levels were negatively associated with special sequence β carboxyterminal peptide of collagen Ⅰ (β-CTX) levels in men and women (male: r=-0.161, P < 0.001; female: r=-0.069, P=0.002). In addition, 25(OH)D levels were positively associated with femoral neck BMD (β=0.001, P=0.019) and total hip BMD (β=0.001, P=0.034) in men.  Conclusion  25(OH)D deficiency and insufficiency are still common in rural areas of Ningbo City, especially among women younger than 50 years old. The results suggest that these people need to pay more attention to their 25(OH)D levels and adjust their lifestyle or use vitamin D supplements early. In addition, 25(OH)D levels were found to be positively associated with BMD and negatively associated with β-CTX levels in this study population.

     

    • FullText(HTML)
  • loading
    • References(19)
  • [1]
    张仕华, 韩悦, 赵彤, 等. 呼伦贝尔地区0~14岁儿童血清25-羟基维生素D水平分析[J]. 浙江医学, 2022, 44(11): 1198-1201. doi: 10.12056/j.issn.1006-2785.2022.44.11.2021-2738

    ZHANG S H, HAN Y, ZHAO T, et al. Serum 25-hydroxyvitamin D levels in children aged 0-14 years in Hulun Buir Region of Inner Mongolia Autonomous Region[J]. Zhejiang Medical Journal, 2022, 44(11): 1198-1201. doi: 10.12056/j.issn.1006-2785.2022.44.11.2021-2738
    [2]
    中华医学会骨质疏松和骨矿盐疾病分会, 章振林. 原发性骨质疏松症诊疗指南(2022)[J]. 中国全科医学, 2023, 26(14): 1671-1691.

    Chinese Society of Osteoporosis and Bone Mineral Research. Guidelines for the diagnosis and treatment of primary osteoporosis(2022)[J]. Chinese General Practice, 2023, 26(14): 1671-1691.
    [3]
    中国营养学会健康管理分会. 维生素D营养状况评价及改善专家共识[J]. 中华健康管理学杂志, 2023, 17(4): 245-252. doi: 10.3760/cma.j.cn115624-20230105-00009

    Health Management branch of Chinese Nutrition Society. Expert consensus on evaluation and improvement of vitamin D nutritional status[J]. Chinese Journal of Health Management, 2023, 17(4): 245-252. doi: 10.3760/cma.j.cn115624-20230105-00009
    [4]
    冯成桢, 李俊伟, 李琰华. 钙剂及维生素D治疗原发性骨质疏松症的有效性与安全性研究进展[J]. 中华全科医学, 2020, 18(4): 642-645.

    FENG C Z, LI J W, LI Y H. Progress in the efficacy and safety of calcium and vitamin D in the treatment of primary osteoporosis[J]. Chinese Journal of General Practice, 2020, 18(4): 642-645.
    [5]
    高晓蔓, 何建乐, 许夕海, 等. 合肥某三甲医院4 311例体检人群血清25-羟维生素D水平与相关因素的分析[J]. 中华全科医学, 2023, 21(8): 1304-1307.

    GAO X M, HE J L, XU X H, et al. Analysis of serum 25-hydroxyvitamin D levels and related factors in a population of 4311 physical examinations in a tertiary hospital in Hefei[J]. Chinese Journal of General Practice, 2023, 21(8): 1304-1307.
    [6]
    许海琦, 杨历新, 李金娟, 等. 青海高原成年居民血清25(OH)D水平及相关骨代谢指标的测定和影响因素[J]. 中国骨质疏松杂志, 2023, 29(3): 385-389, 402.

    XU H Q, YANG L X, LI J J, et al. Analysis of the level of serum 25(OH)D and bone metabolism indexes and their influence factors in adult residents in Qinghai plateau[J]. Chinese Journal of Osteoporosis, 2023, 29(3): 385-389, 402.
    [7]
    何雪冬, 王芳, 廖顺琪, 等. 中国成人血清25羟维生素D水平与骨密度相关性的Meta分析[J]. 中国骨质疏松杂志, 2021, 27(6): 808-812. doi: 10.3969/j.issn.1006-7108.2021.06.006

    HE X D, WANG F, LIAO S Q, et al. The correlation between serum 25-hydroxyvitamin D level and bone mineral density in Chinese adults: A meta-analysis[J]. Chinese Journal of Osteoporosis, 2021, 27(6): 808-812. doi: 10.3969/j.issn.1006-7108.2021.06.006
    [8]
    CHEN X, SHEN L, GAO C, et al. Vitamin D status and its associations with bone mineral density, bone turnover markers, and parathyroid hormone in Chinese postmenopausal women with osteopenia and osteoporosis[J]. Front Nutr, 2024, 10(1307896): 1-10. DOI: 10.3389/fnut.2023.1307896.
    [9]
    NAIR S, BHADRICHA H, HATKAR S, et al. Effect of vitamin D levels on bone remodeling in healthy women[J]. Int J Endocrinol Metab, 2020, 18(2): e100656. DOI: 10.5812/ijem.100656.
    [10]
    PLUDOWSKI P, TAKACS I, BOYANOV M, et al. Clinical practice in the prevention, diagnosis and treatment of vitamin D deficiency: a central and Eastern European expert consensus statement[J]. Nutrients, 2022, 14(7): 1483. DOI: 10.3390/nu14071483.
    [11]
    CUI A Y, ZHANG T S, XIAO P L, et al. Global and regional prevalence of vitamin D deficiency in population-based studies from 2000 to 2022: a pooled analysis of 7.9 million participants[J]. Front Nutr, 2023, 10: (1070808): 1-13. DOI: 10.3389/fnut.2023.1070808.
    [12]
    谢洁雯, 魏秋静, 吴中鸣, 等. 广州地区体检人群维生素D水平分析[J]. 中华临床实验室管理电子杂志, 2020, 8(4): 224-227. doi: 10.3877/cma.j.issn.2095-5820.2020.04.008

    XIE J W, WEI Q J, WU Z M, et al. Analysis of vitamin D level in people taking physical examination in Guangzhou[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2020, 8(4): 224-227. doi: 10.3877/cma.j.issn.2095-5820.2020.04.008
    [13]
    赵滢, 苏艳丹, 唐睿珠, 等. 昆明地区2 563例人群维生素D营养的状况[J]. 昆明医科大学学报, 2022, 43(4): 19-25.

    ZHAO Y, SU Y D, TANG R Z, et al. Vitamin D status of 2563 subj ects in Kunming[J]. Journal of Kunming Medical University, 2022, 43(4): 19-25.
    [14]
    高杲, 陈晓. 上海地区成人维生素D水平与性别、年龄、季节的关系[J]. 中国骨质疏松杂志, 2022, 28(2): 280-284. doi: 10.3969/j.issn.1006-7108.2022.02.022

    GAO H, CHEN X. Serum vitamin D levels in Shanghai adults: effects of gender, age and season[J]. Chinese Journal of Osteoporosis, 2022, 28(2): 280-284. doi: 10.3969/j.issn.1006-7108.2022.02.022
    [15]
    何梦洁, 邹艳, 黄李春, 等. 2018年浙江省成人维生素D营养状况及影响因素[J]. 卫生研究, 2022, 51(5): 844-848.

    HE M J, ZOU Y, HUANG L C, et al. Nutritional status and influencing factors of vitamin D in adults in Zhejiang Province in 2018[J]. Journal of Hygiene Research, 2022, 51(5): 844-848.
    [16]
    肖玲, 徐玉兵, 程雅婷, 等. 10 696例60岁以上老年人群血清25-羟基维生素D水平调查[J]. 国际检验医学杂志, 2020, 41(5): 578-582. doi: 10.3969/j.issn.1673-4130.2020.05.015

    XIAO L, XU Y B, CHENG Y T, et al. Investigation of serum 25-hydroxyvitamin D level in 10696 elderly people over 60 years old[J]. International Journal of Laboratory Medicine, 2020, 41(5): 578-582. doi: 10.3969/j.issn.1673-4130.2020.05.015
    [17]
    WANG L K, HUNG K C, LIN Y T, et al. Age, gender and season are good predictors of vitamin D status independent of body mass index in office workers in a subtropical region[J]. Nutrients, 2020, 12(9): 2719. DOI: 10.3390/nu12092719.
    [18]
    SKULADOTTIR S S, RAMEL A, EYMUNDSDOTTIR H, et al. Serum 25-hydroxyvitamin D status and incident hip fractures in elderly adults: looking beyond bone mineral density[J]. J Bone Miner Res, 2021, 36(12): 2351-2360.
    [19]
    KONG S H, JANG H N, KIM J H, et al. Effect of vitamin D supplementation on risk of fractures and falls according to dosage and interval: a meta-analysis[J]. Endocrinol Metab (Seoul), 2022, 37(2): 344-358. doi: 10.3803/EnM.2021.1374
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (25) PDF downloads(1) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return