Volume 23 Issue 1
Jan.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(1): 40-44
ZHAO Hao, ZHANG Wenjing, YANG Zi, ZHANG Xiaofeng, NIU Jiaqi, SONG Xue. Abnormal expression and clinical significance of CABYR in gastric cancer[J]. Chinese Journal of General Practice, 2025, 23(1): 40-44. doi: 10.16766/j.cnki.issn.1674-4152.003831
Citation: ZHAO Hao, ZHANG Wenjing, YANG Zi, ZHANG Xiaofeng, NIU Jiaqi, SONG Xue. Abnormal expression and clinical significance of CABYR in gastric cancer[J]. Chinese Journal of General Practice, 2025, 23(1): 40-44. doi: 10.16766/j.cnki.issn.1674-4152.003831
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Abnormal expression and clinical significance of CABYR in gastric cancer

doi: 10.16766/j.cnki.issn.1674-4152.003831
  • 1.

    Department of Central Laboratory, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 KJ2020A056

  • Received Date: 2024-03-19
    Available Online: 2025-02-13
    Abstract
  •   Objective  To investigate the expression of calciumbinding tyrosine phosphorylation-regulated gene (CABYR) in gastric cancer tissues and its relationship with clinicopathological parameters, and to explore its relationship with the long-term prognosis of gastric patient.  Methods  The expression level of CABYR in gastric cancer was analyzed using public cancer databases to assess its impact on disease progression and prognosis. Additionally, 107 gastric cancer patients who underwent radical surgery at the First Affiliated Hospital of Bengbu Medical University from January 2017 to April 2018 were included for validation. Furthermore, the potential biological processes involving CABYR in gastric cancer were predicted using public cancer databases, and its correlation with immune cell infiltration was further analyzed.  Results  Analysis of public cancer databases revealed that the expression level of CABYR in gastric cancer tissue was significantly higher than that in adjacent non-cancerous tissue and was closely associated with clinical staging. Moreover, patients with high CABYR expression had significantly lower postoperative survival rates compared to those with low expression (P < 0.05). In the clinical validation, the expression level of CABYR in gastric cancer tissue was significantly elevated compared to adjacent non-cancerous tissue [(6.944±1.841) vs. (1.000±0.245), P < 0.001], correlating strongly with malignant disease progression. Additionally, the 5-year postoperative survival rate of patients with high CABYR expression was significantly lower compared to the low-expression group (log-rank χ2=32.799, P < 0.05). Cox regression analysis showed that high CABYR expression as an independent risk factor for reduced 5-year postoperative survival (HR=2.985, 95% CI: 1.460-6.104). ROC curve analysis demonstrated that CABYR predicted cancer-related death with 80.39% sensitivity and 73.21% specificity (P < 0.05). Further database analysis revealed that the biological function of CABYR in gastric cancer was mainly associated with immune cell infiltration.  Conclusion  High expression of CABYR is closely associated with gastric cancer progression and can serve as a biomarker for evaluating clinical prognosis.

     

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