Relationship of perineural invasion with clinicopathological features and prognosis in breast cancer patients

PENG Puchao; CHEN Lijie; XUAN Haojun; YAO Min; DENG Zaixing; ZHANG Xin; DING Xiufang

doi:10.16766/j.cnki.issn.1674-4152.003834

Volume 23 Issue 1

Jan. 2025

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Article Navigation > Chinese Journal of General Practice > 2025 > 23(1): 55-58

PENG Puchao, CHEN Lijie, XUAN Haojun, YAO Min, DENG Zaixing, ZHANG Xin, DING Xiufang. Relationship of perineural invasion with clinicopathological features and prognosis in breast cancer patients[J]. Chinese Journal of General Practice, 2025, 23(1): 55-58. doi: 10.16766/j.cnki.issn.1674-4152.003834

Citation:

PENG Puchao, CHEN Lijie, XUAN Haojun, YAO Min, DENG Zaixing, ZHANG Xin, DING Xiufang. Relationship of perineural invasion with clinicopathological features and prognosis in breast cancer patients[J]. Chinese Journal of General Practice, 2025, 23(1): 55-58. doi: 10.16766/j.cnki.issn.1674-4152.003834

Citation:

PENG Puchao, CHEN Lijie, XUAN Haojun, YAO Min, DENG Zaixing, ZHANG Xin, DING Xiufang. Relationship of perineural invasion with clinicopathological features and prognosis in breast cancer patients[J]. Chinese Journal of General Practice, 2025, 23(1): 55-58. doi: 10.16766/j.cnki.issn.1674-4152.003834

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Relationship of perineural invasion with clinicopathological features and prognosis in breast cancer patients

doi: 10.16766/j.cnki.issn.1674-4152.003834

PENG Puchao^{1, 2}
, CHEN Lijie^{2
,
,}
, XUAN Haojun³
, YAO Min²
, DENG Zaixing⁴
, ZHANG Xin⁴
, DING Xiufang²

1.
Graduate School, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China

Funds:

2023KY588

Received Date: 2024-01-28
Available Online: 2025-02-13

Abstract

Abstract

Objective The prognostic and survival significance of perineural invasion in breast cancer was not clear, the relationship of perineural invasion with clinicopathological characteristics and the effect on the prognosis of breast cancer were analyzed, so as to provide a basis for accurate evaluation of the prognosis of breast cancer. Methods A total of 159 breast cancer patients in Huzhou Maternal and Child Health Care Hospital from January 2018 to December 2021 were selected as the study subjects. According to the presence of perineural invasion, the patients were divided into the PNI-positive group (n=43) and the PNI-negative group (n=116). The clinicopathological characteristics of two groups of breast cancer patients were compared, and univariate and multivariate logistic regression analysis were used to analyze the risk factors of neural invasion of breast cancer. Moreover, the Kaplan-Meier method was used to draw survival curves to compare the differences in disease-free survival between the two groups of patients. Meantime, Cox regression analysis was used to explore the factors affecting the prognosis of breast cancer patients. Results Among 159 cases of breast cancer, 43 cases (27.0%) had a perineural invasion. Univariate analysis showed that T stage, axillary lymph node metastasis, TNM staging, and the expression levels of Ki-67 of breast cancer were correlated with perineural invasion (P < 0.05); In the logistic binary regression analysis with multiple factor analysis, axillary lymph node metastasis, TNM staging, and the expression levels of Ki-67 were independent factors influencing the occurrence of breast cancer perineural invasion(P < 0.05). The disease-free survival rate of 43 patients with nerve infiltration was 67.4%, while the disease-free survival rate of 116 patients without nerve infiltration was 87.9%. The difference in disease-free survival rates between the two groups was statistically significant (χ²=12.693, P < 0.05). The results of univariate Cox regression analysis showed that estrogen receptor, progesterone receptor, T stage, TNM staging, nuclear grade, neural infiltration, and molecular typing were the prognostic factors for breast cancer patients (P < 0.05); Cox regression analysis showed that triple-negative breast cancer and perineural invasion were independent prognostic factors of patients with breast cancer (P < 0.05). Conclusion Axillary lymph node metastasis, TNM staging, and Ki-67 overexpression were independent related factors of nerve invasion in breast cancer, perineural invasion was an independent prognostic factor of breast cancer patients. It could be used as an indicator to evaluate the prognosis of patients.
- Breast carcinoma,
- Perineural invasion,
- Prognosis

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References(16)

References

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