Curative effect observation of donepezil combined with calcitriol in the treatment of mild cognitive impairment

SHEN Jiaying; FAN Jiajia; ZHANG Chen; WANG Xiaoyan; ZHU Mengna; REN Jingjing

doi:10.16766/j.cnki.issn.1674-4152.003837

Volume 23 Issue 1

Jan. 2025

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Article Navigation > Chinese Journal of General Practice > 2025 > 23(1): 69-72

SHEN Jiaying, FAN Jiajia, ZHANG Chen, WANG Xiaoyan, ZHU Mengna, REN Jingjing. Curative effect observation of donepezil combined with calcitriol in the treatment of mild cognitive impairment[J]. Chinese Journal of General Practice, 2025, 23(1): 69-72. doi: 10.16766/j.cnki.issn.1674-4152.003837

Citation:

SHEN Jiaying, FAN Jiajia, ZHANG Chen, WANG Xiaoyan, ZHU Mengna, REN Jingjing. Curative effect observation of donepezil combined with calcitriol in the treatment of mild cognitive impairment[J]. Chinese Journal of General Practice, 2025, 23(1): 69-72. doi: 10.16766/j.cnki.issn.1674-4152.003837

Citation:

SHEN Jiaying, FAN Jiajia, ZHANG Chen, WANG Xiaoyan, ZHU Mengna, REN Jingjing. Curative effect observation of donepezil combined with calcitriol in the treatment of mild cognitive impairment[J]. Chinese Journal of General Practice, 2025, 23(1): 69-72. doi: 10.16766/j.cnki.issn.1674-4152.003837

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Curative effect observation of donepezil combined with calcitriol in the treatment of mild cognitive impairment

doi: 10.16766/j.cnki.issn.1674-4152.003837

SHEN Jiaying^{1, 2, 3}
, FAN Jiajia^{1, 2, 3}
, ZHANG Chen⁴
, WANG Xiaoyan⁴
, ZHU Mengna⁴
, REN Jingjing^{5
,
,}

1.
Department of General Practice, Huzhou Central Hospital, Huzhou, Zhenjiang 313000, China

Funds:

2022KY370

2023KY1186

2024KY1662

Received Date: 2024-01-28
Available Online: 2025-02-13

Abstract

Abstract

Objective The present study aims to compare and analyze the clinical efficacy of donepezil monotherapy versus the combination therapy of donepezil and calcitriol in treating mild cognitive impairment (MCI), with the intention of providing a scientific basis and guidance for therapeutic regimens for MCI patients. Methods A total of 172 MCI patients were selected from Huzhou Central Hospital from February 2020 to July 2022 and divided into a control group (74 cases) and an observation group (98 cases) by random number table method. The control group was given donepezil (5 mg/d) and placebo (saline capsule, 1 pill/d) on the basis of non-drug treatment. The observation group was given donepezil (5 mg/d) and calcitriol (0.25 μg/d). Mini-mental state examination (MMSE) scale, Montreal cognitive assessment (MoCA) scale, and functional activity questionnaire (FAQ) were compared between the two groups at the 6th month and 12th month. Results There were statistically significant improvements in MMSE, MoCA, and FAQ in both groups at the 6th month and 12th month compared to baseline (P < 0.05). With the 12th month as the main endpoint, the MMSE of the observation group was better than that of the control group (P < 0.05), and there were no significant differences in MoCA and FAQ between the two groups (P>0.05); The incidence of adverse drug reactions in the control group and observation group was 1.35% (1/74) and 1.02% (1/98), respectively, and the proportion of poor medication adherence was 12.16% (9/74) and 11.22% (11/98), respectively. There were no statistically significant between the two groups (P=0.999, 0.849). Conclusion Donepezil or combined administration of donepezil + calcitriol based on non-drug intervention has a favorable impact on MCI patients, but the drug combination scheme does not exhibit evident advantages.
- Mild cognitive impairment,
- Vitamin D,
- Donepezil,
- Calcitriol

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References(20)

References

[1]	HUSSAIN A, SHEIKH Z, SUBRAMANIAN M. The eye as a diagnostic tool for Alzheimer' s disease[J]. Life(Basel), 2023, 13(3): 2075-1729.
[2]	LAU K, DIMITRIADIS P A, MITCHELL C, et al. Age-related hearing loss and mild cognitive impairment: a meta-analysis and systematic review of population-based studies[J]. J Laryngol Otol, 2022, 136(2): 103-118. doi: 10.1017/S0022215121004114
[3]	TEH W L, ABDIN E, VAINGANKAR J A, et al. Prevalence, lifestyle correlates, and psychosocial functioning among multi-ethnic older adults with mild cognitive impairment in Singapore: preliminary findings from a 10/66 population study[J]. Yale J Biol Med, 2021, 94(1): 73-83.
[4]	DENG Y, ZHAO S, CHENG G, et al. The prevalence of mild cognitive impairment among chinese people: a meta-analysis[J]. Neuroepidemiology, 2021, 55(2): 79-91. doi: 10.1159/000512597
[5]	孙棋圻, 高可润. 轻度认知功能障碍患者睡眠特征及其与认知功能的相关性分析[J]. 中华全科医学, 2023, 21(5): 825-828. doi: 10.16766/j.cnki.issn.1674-4152.002993 SUN Q Q, GAO K R. Sleep characteristics and their correlation with cognitive function in patients with mild cognitive impairment[J]. Chinese Journal of General Practice, 2023, 21(5): 825-828. doi: 10.16766/j.cnki.issn.1674-4152.002993
[6]	赵蕴晗, 秦虹云, 诸秉根, 等. 上海市浦东新区老年人睡眠质量与认知功能的相关性分析[J]. 国际精神病学杂志, 2021, 48(3): 454-458, 465. ZHAO Y H, QIN H Y, ZHU B G, et al. Correlation Analysis between Sleep Quality and cognitive Function of the Elderly in Pudong New Area of Shanghai[J]. Journal of International Psychiatry, 2021, 48(3): 454-458, 465.
[7]	王玉琳, 张亚珂, 李超然, 等. 轻度认知功能障碍的临床常用筛查评价量表研究进展[J]. 神经损伤与功能重建, 2021, 16(9): 522-525. WANG Y L, ZHANG Y K, LI C R, et al. Research progress on commonly used clinical screening and evaluation scales for mild cognitive impairment[J]. Neural Injury And Functional Reconstruction, 2021, 16(9): 522-525. [8] MAVRAKI E, IOANNIDIS P, TRIPSIANIS G, et al. Vitamin D in mild cognitive impairment and Alzheimer' s disease: a study in older Greek adults[J]. Hippokratia, 2020, 24(3): 120-126.
[8]	MAVRAKI E, IOANNIDIS P, TRIPSIANIS G, et al. Vitamin D in mild cognitive impairment and Alzheimer' s disease: a study in older Greek adults[J]. Hippokratia, 2020, 24(3): 120-126.
[9]	ZEQAJ I, PIFFERO R, CALZADUCCA E, et al. The potential role of vitamin D supplementation in cognitive impairment prevention[J]. CNS Neurol Disord Drug Targets, 2024, 23(5): 628-637. doi: 10.2174/1871527322666230328130417
[10]	KANG J, PARK M, LEE E, et al. The Role of Vitamin D in Alzheimer' s Disease: a transcriptional regulator of amyloidopathy and gliopathy[J]. Biomedicines, 2022, 10(8): 1824. doi: 10.3390/biomedicines10081824
[11]	FEI H X, QIAN C F, WU X M, et al. Role of micronutrients in Alzheimer' s disease: review of available evidence[J]. World J Clin Cases, 2022, 10(22): 7631-7641. doi: 10.12998/wjcc.v10.i22.7631
[12]	YANG T, WANG H, XIONG Y, et al. Vitamin D supplementation improves cognitive function through reducing oxidative stress regulated by telomere length in older adults with mild cognitive impairment: a 12-month randomized controlled trial[J]. J Alzheimers Dis, 2020, 78(4): 1509-1518. doi: 10.3233/JAD-200926
[13]	CHENG L, DONG R, SONG C, et al. Mediation effects of IL-1β and IL-18 on the association between vitamin D levels and mild cognitive impairment among Chinese older adults: a case-control study in Taiyuan, China[J]. Front Aging Neurosci, 2022, 14: 836311. DOI: 10.3389/fnagi.2022.836311.
[14]	MARTIN-ROMERO A, PERELLO-MARTINEZ J, HIDALGO-SANTIAGO J C, et al. Effect of the administration of different forms of vitamin D on central blood pressure and aortic stiffness, and its implication in the reduction of albuminuria in chronic kidney disease[J]. Clin Investig Arterioscler, 2022, 34(6): 311-321.
[15]	RIVERA-RIVERA L A, CODY K A, EISENMENGER L, et al. Assessment of vascular stiffness in the internal carotid artery proximal to the carotid canal in Alzheimer' s disease using pulse wave velocity from low rank reconstructed 4D flow MRI[J]. J Cereb Blood Flow Metab, 2021, 41(2): 298-311. doi: 10.1177/0271678X20910302
[16]	HWANG S, SOUNG Y G, KANG S U, et al. Association between persistent treatment of Alzheimer' s dementia and osteoporosis using a common data model[J]. Dement Neurocogn Disord, 2023, 22(4): 121-129. doi: 10.12779/dnd.2023.22.4.121
[17]	GIL MARTINEZ V, AVEDILLO SALAS A, SANTANDER BALLESTIN S. Vitamin supplementation and dementia: a systematic review[J]. Nutrients, 2022, 14(5): 1033. doi: 10.3390/nu14051033.
[18]	GIL MARTINEZ V, AVEDILLO SALAS A, SANTANDER BALLESTIN S. Effects of exercise alone or combined with cognitive training and vitamin D supplementation to improve cognition in adults with mild cognitive impairment: a randomized clinical trial[J]. JAMA Netw Open, 2023, 6(7): e2324465. DOI: 10.1001/jamanetworkopen.2023.24465.
[19]	KATABATHULA S, DAVIS PB, XU R. Comorbidity-driven multi-modal subtype analysis in mild cognitive impairment of Alzheimer' s disease[J]. Alzheimers Dement, 2023, 19(4): 1428-1439. doi: 10.1002/alz.12792
[20]	LIU N, ZHANG T, MA L, et al. Vitamin D receptor gene polymorphisms and risk of Alzheimer disease and mild cognitive impairment: a systematic review and meta-analysis[J]. Adv Nutr, 2021, 12(6): 2255-2264.

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Curative effect observation of donepezil combined with calcitriol in the treatment of mild cognitive impairment

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