Analysis clinical characteristics and pathology of colorectal polyps in various age groups

ZHAO Ning; WANG Yuanyuan; JIANG Xia; ZHAO Zengren

doi:10.16766/j.cnki.issn.1674-4152.003448

Volume 22 Issue 4

Apr. 2024

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Article Navigation > Chinese Journal of General Practice > 2024 > 22(4): 555-558

ZHAO Ning, WANG Yuanyuan, JIANG Xia, ZHAO Zengren. Analysis clinical characteristics and pathology of colorectal polyps in various age groups[J]. Chinese Journal of General Practice, 2024, 22(4): 555-558. doi: 10.16766/j.cnki.issn.1674-4152.003448

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ZHAO Ning, WANG Yuanyuan, JIANG Xia, ZHAO Zengren. Analysis clinical characteristics and pathology of colorectal polyps in various age groups[J]. Chinese Journal of General Practice, 2024, 22(4): 555-558. doi: 10.16766/j.cnki.issn.1674-4152.003448

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Analysis clinical characteristics and pathology of colorectal polyps in various age groups

doi: 10.16766/j.cnki.issn.1674-4152.003448

ZHAO Ning¹
, WANG Yuanyuan^{1, 2}
, JIANG Xia^{1, 2}
, ZHAO Zengren^{1, 2
,
,}

1.
Gastrointestinal Disease Center, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China

Funds:

82203623

YZ202201

YZ202305

H2020206374

LS202001

Received Date: 2023-12-02
Available Online: 2024-05-29

Abstract

Abstract

Objective This study aims to investigate the characteristics of colorectal polyps in different age populations, providing a clinical foundation for early screening of intestinal tumors. Methods We conducted a retrospective analysis of clinical data from 571 patients with colorectal polyps at the First Hospital of Hebei Medical University, covering the period from April 2022 to March 2023. These patients were divided into three groups based on age: young group (75 patients, ≤44 years old), middle-aged group (256 patients, 45-59 years old), and elderly group (240 patients, ≥60 years old). The biological characteristics of colorectal polyps in each group were analyzed using the Chi-squared test. Results Male patients were more common in the young and middle-aged groups, whereas female patients were more prevalent in the elderly group (P < 0.001). Comparing the three groups, the incidence of polyps in the ascending colon was highest in elderly group (P=0.002), and the incidence of rectal polyps was highest in young group (P=0.001). Notably, the elderly group exhibited a significantly higher incidence of neoplastic rectal polyps compared to the middle-aged and young group [64.7% (139/215) vs. 34.9% (60/172) vs. 21.2% (14/66), P < 0.001]. Additionally, the incidence of multiple polyps, polyps with a size ≥1.0 cm, and tubular adenomas were highest in elderly group (P < 0.05), while there was no significant difference in the lengths among different pathological types of polyps (P>0.05). The incidence of tubular adenomas in polyps with ≤0.5 cm and 0.6-0.9 cm were highest in elderly group (P < 0.001), while the incidence of hyperplastic polyps was lowest in elderly group (P < 0.001). However, there was no significant difference in the pathological types of polyps with a size ≥1.0 cm among the three groups, with tubular adenomas being the most common for this size polyps (P>0.05). Conclusion The biological characteristics of colorectal polyps exhibit variations across different age groups, including changes in the risk population, growth position, size, number, and pathological types, which tend to follow a discernible trend with increasing age.
- Colorectal polyp,
- Age,
- Clinical characteristics,
- Pathological features

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References(18)

References

[1]	SUNG H, FERLAY J, SIEGEL R, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71: 209-249. doi: 10.3322/caac.21660
[2]	PATEL S G, KARLITZ J J, YEN T, et al. The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection[J]. Lancet Gastroenterol Hepatol, 2022, 7: 262-274. doi: 10.1016/S2468-1253(21)00426-X
[3]	樊启林, 张松, 文峰, 等. 1 474例不同年龄段结直肠癌患者的临床病理特征及预后分析[J]. 实用肿瘤杂志, 2023, 38(2): 127-132. https://www.cnki.com.cn/Article/CJFDTOTAL-SYZZ202302006.htm FAN Q L, ZHANG S, WEN F, et al. Clinicopathological features and prognosis of 1 474 colorectal cancer patients of different ages[J]. Journal of Practical Oncology, 2023, 38(2): 127-132. https://www.cnki.com.cn/Article/CJFDTOTAL-SYZZ202302006.htm
[4]	杨燕青, 芮蓉, 武鹏涛, 等. 消蕈化浊方对肠息肉伴代谢综合征的临床疗效及影响因素分析[J]. 中华全科医学, 2023, 21(4): 677-680. doi: 10.16766/j.cnki.issn.1674-4152.002958 YANG Y Q, RUI R, WU P T, et al. Clinical effect of Xiaoxun Huazhuo Recipe on colorectal polyps with metabolic syndrome and influencing factors[J]. Chinese Journal of General Practice, 2023, 21(4): 677-680. doi: 10.16766/j.cnki.issn.1674-4152.002958
[5]	武雅峰. 2 574例不同年龄段结直肠息肉患者临床及癌变特征分析[D]. 太原: 山西医科大学, 2021. WU Y F. Analysis of clinical and cancerous characteristics in 2 574 patients with colorectal polyps of different age groups[D]. Taiyuan: Shanxi Medical University, 2021.
[6]	PAN J, CEN L, XU L, et al. Prevalence and risk factors for colorectal polyps in a Chinese population: a retrospective study[J]. Sci Rep, 2020, 10: 6974. DOI: 10.1038/s41598-020-63827-6.
[7]	HUA H, JIANG Q, SUN P, et al. Risk factors for early-onset colorectal cancer: systematic review and meta-analysis[J]. Front Oncol, 2023, 5(13): 1132306. DOI: 10.3389/fonc.2023.1132306.
[8]	DITONNO I, LOSURDO G, RENDINA M, et al. Estrogen receptors in colorectal cancer: facts, novelties and perspectives[J]. Curr Oncol, 2021, 28(6): 4256-4263. doi: 10.3390/curroncol28060361
[9]	DAS P K, SAHA J, PILLAI S, et al. Implications of estrogen and its receptors in colorectal carcinoma[J]. Cancer Med, 2023, 12: 4367-4379. doi: 10.1002/cam4.5242
[10]	LI Q, CHAN H, LIU W, et al. Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice[J]. Cancer Cell, 2023, 41: 1450-1465. doi: 10.1016/j.ccell.2023.06.011
[11]	WISMAYER R, KIWANUKA J, WABINGA H, et al. Colorectal adenocarcinoma in Uganda: are right-sided and left-sided colon cancers two distinct disease entities?[J]. World J Surg Oncol, 2023, 21: 215. doi: 10.1186/s12957-023-03094-7
[12]	闫超, 陕飞, 李子禹. 2020年中国与全球结直肠癌流行概况分析[J]. 中华肿瘤杂志, 2023, 45(3): 221-229. https://www.cnki.com.cn/Article/CJFDTOTAL-DEJD202212001.htm YAN C, SHAN F, LI Z Y. Prevalence of colorectal cancer in 2020: a comparative analysis between China and the world[J]. Chinese Journal of Oncology, 2023, 45(3): 221-229. https://www.cnki.com.cn/Article/CJFDTOTAL-DEJD202212001.htm
[13]	王晶, 殷云勤, 文静. 2 942例大肠息肉的临床特点及结肠癌检出率分析[J]. 中国现代医生, 2016, 54(1): 81-84. https://www.cnki.com.cn/Article/CJFDTOTAL-ZDYS201601026.htm WANG J, YIN Y Q, WEN J. The analysis of clinical characteristics of colorectal polyps and detective rate of colorectal carcinomol in 2 942 cases[J]. China Modern Doctor, 2016, 54(1): 81-84. https://www.cnki.com.cn/Article/CJFDTOTAL-ZDYS201601026.htm
[14]	SANG X, WANG Q, NING Y, et al. Age-related mucus barrier dysfunction in mice is related to the changes in Muc2 mucin in the colon[J]. Nutrients, 2023, 15(8): 1830. DOI: 10.3390/nu15081830.
[15]	PATANKAR J, BECKER C. Cell death in the gut epithelium and implications for chronic inflammation[J]. Nat Rev Gastroenterol Hepatol, 2020, 17: 543-556. doi: 10.1038/s41575-020-0326-4
[16]	MANDIC O, JOVANOVIC I, CVETKOVIC M, et al. Factors predicting malignant occurrence and polyp recurrence after the endoscopic resection of large colorectal polyps: a single center experience[J]. Medicina(Kaunas), 2022, 58(10): 1440.
[17]	LIANG S, MAO Y, LIAO M, et al. Gut microbiome associated with APC gene mutation in patients with intestinal adenomatous polyps[J]. Int J Biol Sci, 2020, 16: 135-146.
[18]	ZHAO H, MING T, TANG S, et al. Wnt signaling in colorectal cancer: pathogenic role and therapeutic target[J]. Mol Cancer, 2022, 21: 144.

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Analysis clinical characteristics and pathology of colorectal polyps in various age groups

doi: 10.16766/j.cnki.issn.1674-4152.003448