Survival and prognostic factors of hypofractionated radiation therapy with helical tomotherapy for pulmonary oligometastases

CHEN Ru-jun; SUN Qian; WANG Geng-ming; JIANG Hao

doi:10.16766/j.cnki.issn.1674-4152.002582

Volume 20 Issue 8

Aug. 2022

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Article Navigation > Chinese Journal of General Practice > 2022 > 20(8): 1302-1306

CHEN Ru-jun, SUN Qian, WANG Geng-ming, JIANG Hao. Survival and prognostic factors of hypofractionated radiation therapy with helical tomotherapy for pulmonary oligometastases[J]. Chinese Journal of General Practice, 2022, 20(8): 1302-1306. doi: 10.16766/j.cnki.issn.1674-4152.002582

Citation:

CHEN Ru-jun, SUN Qian, WANG Geng-ming, JIANG Hao. Survival and prognostic factors of hypofractionated radiation therapy with helical tomotherapy for pulmonary oligometastases[J]. Chinese Journal of General Practice, 2022, 20(8): 1302-1306. doi: 10.16766/j.cnki.issn.1674-4152.002582

Citation:

CHEN Ru-jun, SUN Qian, WANG Geng-ming, JIANG Hao. Survival and prognostic factors of hypofractionated radiation therapy with helical tomotherapy for pulmonary oligometastases[J]. Chinese Journal of General Practice, 2022, 20(8): 1302-1306. doi: 10.16766/j.cnki.issn.1674-4152.002582

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Survival and prognostic factors of hypofractionated radiation therapy with helical tomotherapy for pulmonary oligometastases

doi: 10.16766/j.cnki.issn.1674-4152.002582

Department of Radiation Oncology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

1408085MH190

KJ2021A0715

2020b07030008

Received Date: 2022-01-02
Available Online: 2022-09-26

Abstract

Abstract

Objective Helical tomography (HT) has great advantages in protecting the normal tissues and organs around multiple lesions and large tumours and reducing the toxicity of radiotherapy. The aim of this study was to analyse treatment outcomes after hypofractionated stereotactic radiation therapy with HT for pulmonary oligometastases and identify prognostic factors for better survival outcomes. Methods The data of 45 patients with lung oligometastases who completed helical tomographic hypofractionation radiotherapy in the Department of tumor radiotherapy, the First Affiliated Hospital of Bengbu Medical College from January 1, 2018 to June, 30, 2021 were retrospectively analyzed. Kaplan-Meier was used to estimate overall survival (OS), local control rate (LCR) and progression-free survival (PFS). The Cox proportional hazards model was used to determine the independent prognostic factors of the patients. Treatment-related toxicity was evaluated using common terminology criteria for adverse events (CTCAE) version 5.0. Results Follow-up was performed until September 30, 2021. All patients completed the treatment plan during a median follow-up of 16.0 (12.3, 24.2) months. The median biological effective dose was 76.8 (72.8, 90.0) Gy. The 1-year and 2-year OS rates were 94.8% and 58.1%, respectively. The 1-year and 2-year local control rates were 83.8% and 74.1%, respectively. The 1-year and 2-year PFS rates were 57.8% and 43.3%, respectively. The Karnofsky performance status (KPS)>80 before treatment was significantly associated with better LCR in univariate analysis (P=0.043). Multivariate analysis showed that distant lymph node metastasis before diagnosis of lung metastases was associated with better OS (P=0.041, HR=3.014, 95% CI: 1.043-8.706); 4D computed tomography remained an independent factor significantly associated with better PFS (P=0.035, HR=2.693, 95% CI: 1.072-6.761). No treatment-related deaths and grade≥3 toxicities occurred. Conclusion Hypofractionated stereotactic radiation therapy with HT for lung oligometastases is safe and effective. Patients with KPS>80 and no distant lymph node metastasis before diagnosis of lung metastasis has a longer survival time.
- Pulmonary oligometastases,
- Helical tomotherapy,
- Hypofractionated radiotherapy,
- Prognostic factors

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Survival and prognostic factors of hypofractionated radiation therapy with helical tomotherapy for pulmonary oligometastases

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Survival and prognostic factors of hypofractionated radiation therapy with helical tomotherapy for pulmonary oligometastases

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